Immunotoxicogenomics: A Multidisciplinary Approach in Systems Toxicology provides broad coverage to diverse aspects of immunotoxicogenomics. The book covers the major mechanisms and effects of toxic substances on the immune system and on the regulation of gene expression. This includes the aims, opportunities, clinical applications, recent developments, emerging and future trends in immunotoxicogenomics.The book starts off with a discussion of the systemic approach to the study of toxicants. It also looks at the current genomic tools used to assess immunotoxicity and the systems biology methods used in immuno-toxicogenomics. Other topics include genomic expression profiling, the use of gene expression as a tool to understand and predict immunotoxicity, immunotox-icogenomics as a screening tool, and the assessment and analysis of Immunotoxicogenomics data. Future trends round off the discussion in the book. Immunotoxicogenomics: A Multidisciplinary Approach in Systems Toxicology provides a collaborative multidisciplinary approach for researchers in the fields of toxicology, genetics, and immunology and others engaged in the study on the effects of toxic substances on immune responses.
1. Immunotoxicogenomics - p. iii 2. Cover - p. iii 3. Title Page - p. iii 4. Copyright - p. iv 5. Table of Contents - p. iv 6. Contributors - p. xiii 7. About the editors - p. xix 8. Preface - p. xxi 9. Chapter 1 Immunotoxicogenomics: A systemic approach in the study of toxicants - p. 1 10. Chapter 2 Immunotoxicogenomics: A potential approach for comprehending toxicity mechanisms and enhancing risk assessment - p. 27 11. Chapter 3 Current systems biology methods used in immunotoxicogenomics - p. 37 12. Chapter 4 Immunogenetic reaction to ecotoxicants - p. 67 13. Chapter 5 Genomic expression profiling: A potent approach in the study of immunotoxicity - p. 89 14. Chapter 6 Recent development and new opportunities in immunotoxicogenomics - p. 115 15. Chapter 7 Understanding and predicting induced immunotoxicity from gene expression - p. 149 16. Chapter 8 Application of immunotoxicogenomic data in human risk assessment process - p. 167 17. Chapter 9 Immunotoxicogenomics: Moving from observation to prediction - p. 181 18. Chapter 10 Microarray analysis to decipher the effects of immunosuppressive compounds in gene expression modulations - p. 207 19. Chapter 11 Successful use of immunotoxicogenomics as a screening tool - p. 227 20. Chapter 12 Network and pathway analysis of toxicogenomics data - p. 249 21. Chapter 13 The current status and future trends in immunotoxicogenomics - p. 261 22. Index - p. 279
Immunotoxicogenomics: A Multidisciplinary Approach in Systems Toxicology provides broad coverage to diverse aspects of immunotoxicogenomics. The book covers the major mechanisms and effects of toxic substances on the immune system and on the regulation of gene expression. This includes the aims, opportunities, clinical applications, recent developments, emerging and future trends in immunotoxicogenomics.The book starts off with a discussion of the systemic approach to the study of toxicants. It also looks at the current genomic tools used to assess immunotoxicity and the systems biology methods used in immuno-toxicogenomics. Other topics include genomic expression profiling, the use of gene expression as a tool to understand and predict immunotoxicity, immunotox-icogenomics as a screening tool, and the assessment and analysis of Immunotoxicogenomics data. Future trends round off the discussion in the book. Immunotoxicogenomics: A Multidisciplinary Approach in Systems Toxicology provides a collaborative multidisciplinary approach for researchers in the fields of toxicology, genetics, and immunology and others engaged in the study on the effects of toxic substances on immune responses.
1. Immunotoxicogenomics - p. iii 2. Cover - p. iii 3. Title Page - p. iii 4. Copyright - p. iv 5. Table of Contents - p. iv 6. Contributors - p. xiii 7. About the editors - p. xix 8. Preface - p. xxi 9. Chapter 1 Immunotoxicogenomics: A systemic approach in the study of toxicants - p. 1 10. Chapter 2 Immunotoxicogenomics: A potential approach for comprehending toxicity mechanisms and enhancing risk assessment - p. 27 11. Chapter 3 Current systems biology methods used in immunotoxicogenomics - p. 37 12. Chapter 4 Immunogenetic reaction to ecotoxicants - p. 67 13. Chapter 5 Genomic expression profiling: A potent approach in the study of immunotoxicity - p. 89 14. Chapter 6 Recent development and new opportunities in immunotoxicogenomics - p. 115 15. Chapter 7 Understanding and predicting induced immunotoxicity from gene expression - p. 149 16. Chapter 8 Application of immunotoxicogenomic data in human risk assessment process - p. 167 17. Chapter 9 Immunotoxicogenomics: Moving from observation to prediction - p. 181 18. Chapter 10 Microarray analysis to decipher the effects of immunosuppressive compounds in gene expression modulations - p. 207 19. Chapter 11 Successful use of immunotoxicogenomics as a screening tool - p. 227 20. Chapter 12 Network and pathway analysis of toxicogenomics data - p. 249 21. Chapter 13 The current status and future trends in immunotoxicogenomics - p. 261 22. Index - p. 279
