Implementation of Personalized Precision Medicine: Expanding the Clinical Vision towards Prevention, Early Detection, and Precision Treatment of Disease to Drive Extended Healthspan establishes the landscape of precision medicine as it stands in relation to implementation of individualized approaches based on the patient’s unique genomic and biochemical make-up to facilitate prevention, early detection and personalized interventions. This reference details how these lofty goals are now achievable with the science of today (and tomorrow) and provides the context and blueprint allowing researchers and clinicians to avoid, and more effectively treat, complex chronic disease.At the heart of precision medicine lies one concept that has been missing from modern medicine–the unique genetic and biochemical make-up of each individual patient. Uniquely organized, this reference reflects this concept and provides insights into patient constitution, genetic inherited risk, current epigenetic modifications, and current biochemical state, making this reference valuable to researchers and science-minded providers who modified, reverse or prevent disease progression.
1. Implementation of Personalized Precision Medicine - p. i 2. Cover - p. i 3. Title Page - p. iii 4. Copyright Page - p. iv 5. Table of Contents - p. iv 6. Contributors - p. xv 7. Editor’s statement - p. xvii 8. Chapter 1 Epigenetics and methylation risk scores - p. 1 9. Chapter 2 Polygenic risk scores: A conceptual overview to add PRS to your clinical toolbox - p. 23 10. Chapter 3 The proteomics revolution: Forging a new path to personalized health care - p. 35 11. Chapter 4 Pharmacogenetic clinical implementation - p. 51 12. Chapter 5 Seeing clearly to treat precisely: Advances in molecular imaging and theranostics in precision health - p. 67 13. Chapter 6 Early quantum computing applications on the path towards precision medicine - p. 83 14. Chapter 7 Gene therapy: State of the art precision medicine - p. 97 15. Chapter 8 Precision mitochondrial medicine: Uncovering pathways across diverse diseases - p. 115 16. Chapter 9 Antigen-specific immunotherapy: The ultimate precision medicine for the treatment of autoimmune diseases - p. 171 17. Chapter 10 The future of precision diabetes: Digital twin - p. 191 18. Chapter 11 Precision oncology: Indications and challenges in the implementation of high-throughput sequencing in clinical practice - p. 203 19. Chapter 12 Bringing “precision” to psychiatry: Challenges and promises - p. 223 20. Chapter 13 Precision medicine in cardiovascular disease - p. 241 21. Chapter 14 Precision bone health: Genetic testing for low bone density - p. 255 22. Chapter 15 Functional nutrigenomics: A personalized shift in treating inflammation - p. 265 23. Chapter 16 Regulating ferroptosis: Toward precision treatment of dysregulated cell death - p. 293 24. Chapter 17 Precision medicine for brain health and prevention of neurodegenerative/neurocognitive decline - p. 319 25. Chapter 18 The gut microbiome in personalized precision medicine - p. 345 26. Chapter 19 Exposome and detoxification - p. 359 27. Chapter 20 Unraveling the threads of time: Longevity and DNA repair mechanisms - p. 377 28. Chapter 21 Considering ethics in precision medicine - p. 397 29. Chapter 22 Personomics: The personalization of precision medicine - p. 407 30. Index - p. 417
Implementation of Personalized Precision Medicine: Expanding the Clinical Vision towards Prevention, Early Detection, and Precision Treatment of Disease to Drive Extended Healthspan establishes the landscape of precision medicine as it stands in relation to implementation of individualized approaches based on the patient’s unique genomic and biochemical make-up to facilitate prevention, early detection and personalized interventions. This reference details how these lofty goals are now achievable with the science of today (and tomorrow) and provides the context and blueprint allowing researchers and clinicians to avoid, and more effectively treat, complex chronic disease.At the heart of precision medicine lies one concept that has been missing from modern medicine–the unique genetic and biochemical make-up of each individual patient. Uniquely organized, this reference reflects this concept and provides insights into patient constitution, genetic inherited risk, current epigenetic modifications, and current biochemical state, making this reference valuable to researchers and science-minded providers who modified, reverse or prevent disease progression.
1. Implementation of Personalized Precision Medicine - p. i 2. Cover - p. i 3. Title Page - p. iii 4. Copyright Page - p. iv 5. Table of Contents - p. iv 6. Contributors - p. xv 7. Editor’s statement - p. xvii 8. Chapter 1 Epigenetics and methylation risk scores - p. 1 9. Chapter 2 Polygenic risk scores: A conceptual overview to add PRS to your clinical toolbox - p. 23 10. Chapter 3 The proteomics revolution: Forging a new path to personalized health care - p. 35 11. Chapter 4 Pharmacogenetic clinical implementation - p. 51 12. Chapter 5 Seeing clearly to treat precisely: Advances in molecular imaging and theranostics in precision health - p. 67 13. Chapter 6 Early quantum computing applications on the path towards precision medicine - p. 83 14. Chapter 7 Gene therapy: State of the art precision medicine - p. 97 15. Chapter 8 Precision mitochondrial medicine: Uncovering pathways across diverse diseases - p. 115 16. Chapter 9 Antigen-specific immunotherapy: The ultimate precision medicine for the treatment of autoimmune diseases - p. 171 17. Chapter 10 The future of precision diabetes: Digital twin - p. 191 18. Chapter 11 Precision oncology: Indications and challenges in the implementation of high-throughput sequencing in clinical practice - p. 203 19. Chapter 12 Bringing “precision” to psychiatry: Challenges and promises - p. 223 20. Chapter 13 Precision medicine in cardiovascular disease - p. 241 21. Chapter 14 Precision bone health: Genetic testing for low bone density - p. 255 22. Chapter 15 Functional nutrigenomics: A personalized shift in treating inflammation - p. 265 23. Chapter 16 Regulating ferroptosis: Toward precision treatment of dysregulated cell death - p. 293 24. Chapter 17 Precision medicine for brain health and prevention of neurodegenerative/neurocognitive decline - p. 319 25. Chapter 18 The gut microbiome in personalized precision medicine - p. 345 26. Chapter 19 Exposome and detoxification - p. 359 27. Chapter 20 Unraveling the threads of time: Longevity and DNA repair mechanisms - p. 377 28. Chapter 21 Considering ethics in precision medicine - p. 397 29. Chapter 22 Personomics: The personalization of precision medicine - p. 407 30. Index - p. 417
