Inflammasome Biology: Fundamentals, Role in Disease States, and Therapeutic Opportunities is a complete reference on the role of inflammasomes in health and disease. Sections cover the different types of inflammasomes, including cellular signaling, structural and evolutive aspects, overview the role of inflammasomes in key diseases, microbial infections and human body systems conditions, cover the interplay between Inflammasomes and cell death processes, and discuss current therapeutic opportunities driven by inflammasome research, including targeting, blocking and inhibiting the development of inflammasomes through both synthetic and natural compounds.
This book is the perfect reference for cell biologists, immunologists and research clinicians to understand the foundations of inflammasomes and explore the therapeutic opportunities they present. Pharma researchers may also find this reference invaluable in devising new approaches to developing anti-inflammatory drugs.
1. Cover image - p. Cover 2. Title page - p. ii 3. Table of Contents - p. iii 4. Copyright - p. iii 5. Contributors - p. iii 6. List of Tables - p. iii 7. Section 1: Fundamentals of inflammasome biology - p. iii 8. Chapter 1: The inflammatory process at the cellular level - p. iii 9. Chapter 2: Inflammasome formation and triggers - p. 12 10. Chapter 3: The NLRP1 and CARD8 inflammasomes - p. 28 11. Chapter 4: Cellular signaling, molecular activation, and regulation of the NLRP3 inflammasome - p. 45 12. Chapter 5: Cellular signaling, molecular activation, and regulation of the NLRP6 inflammasome - p. 60 13. Chapter 6: Molecular regulation of NAIP/NLRC4 inflammasomes - p. 74 14. Chapter 7: Cellular signaling, molecular activation, and regulation of the AIM2 inflammasome - p. 88 15. Chapter 8: Molecular activation, cellular signaling, and regulation of the Pyrin inflammasome - p. 103 16. Chapter 9: Cellular signaling, molecular activation, and regulation of the noncanonical inflammasome - p. 121 17. Chapter 10: Cellular signaling, molecular activation, and regulation of auto-active inflammasomes: Insights from disease-associated variants - p. 134 18. Chapter 11: Autophagy and the inflammasome - p. 156 19. Chapter 12: Inflammasome effector functions: a Tale of Fire and Ice - p. 169 20. Chapter 13: Inflammatory caspases - p. 193 21. Chapter 14: Structural aspects of inflammasomes forming NOD-like receptors - p. 212 22. Chapter 15: Evolutive aspects of inflammasomes - p. 231 23. Section 2: Inflammasome role in disease processes - p. 242 24. Chapter 16: The inflammasome in cardiovascular diseases - p. 242 25. Chapter 17: Inflammasome implications in metabolic disorders - p. 259 26. Chapter 18: The inflammasome in stroke - p. 270 27. Chapter 19: Inflammasome and neurodegenerative diseases - p. 287 28. Chapter 20: Inflammasomes in cigarette smoke- or ozone-induced lung diseases - p. 317 29. Chapter 21: Inflammasomes and their regulation in oral diseases - p. 335 30. Chapter 22: Inflammasome-induced inflammation and fibrosis in liver - p. 350 31. Chapter 23: Inflammasomes in sepsis - p. 364 32. Chapter 24: The Inflammasome in viral, bacterial, and fungal infections - p. 378 33. Chapter 25: Autoinflammatory disorders - p. 390 34. Chapter 26: The inflammasome in graft-versus-host disease - p. 416 35. Chapter 27: Canonical and noncanonical Inflammasomes in kidney disease - p. 423 36. Chapter 28: Inflammasomes and cancer - p. 436 37. Chapter 29: Inflammasomes in the pathobiology of degenerative retinopathies - p. 459 38. Section 3: Inflammasome cross talk in cell death - p. 475 39. Chapter 30: Regulation of pyroptosis by inflammasomes - p. 475 40. Chapter 31: Crosstalk between necroptosis and the inflammasome - p. 494 41. Chapter 32: Apoptosis and inflammasome regulation - p. 507 42. Chapter 33: Inflammasomes as integral components of PANoptosomes in the regulation of cell death - p. 519 43. Chapter 34: Regulation of neutrophil NETosis by inflammasome - p. 534 44. Section 4: Therapeutic opportunities - p. 549 45. Chapter 35: Therapeutic opportunities targeting the NLRP3 inflammasome - p. 549 46. Chapter 36: Development of selective NLRP3 inflammasome inhibitors - p. 561 47. Chapter 37: Therapeutic targeting of inflammasome signaling by blocking interleukin-1 - p. 580 48. Chapter 38: Multiinflammasome inhibitors - p. 594 49. Index - p. 617
Inflammasome Biology: Fundamentals, Role in Disease States, and Therapeutic Opportunities is a complete reference on the role of inflammasomes in health and disease. Sections cover the different types of inflammasomes, including cellular signaling, structural and evolutive aspects, overview the role of inflammasomes in key diseases, microbial infections and human body systems conditions, cover the interplay between Inflammasomes and cell death processes, and discuss current therapeutic opportunities driven by inflammasome research, including targeting, blocking and inhibiting the development of inflammasomes through both synthetic and natural compounds.
This book is the perfect reference for cell biologists, immunologists and research clinicians to understand the foundations of inflammasomes and explore the therapeutic opportunities they present. Pharma researchers may also find this reference invaluable in devising new approaches to developing anti-inflammatory drugs.
1. Cover image - p. Cover 2. Title page - p. ii 3. Table of Contents - p. iii 4. Copyright - p. iii 5. Contributors - p. iii 6. List of Tables - p. iii 7. Section 1: Fundamentals of inflammasome biology - p. iii 8. Chapter 1: The inflammatory process at the cellular level - p. iii 9. Chapter 2: Inflammasome formation and triggers - p. 12 10. Chapter 3: The NLRP1 and CARD8 inflammasomes - p. 28 11. Chapter 4: Cellular signaling, molecular activation, and regulation of the NLRP3 inflammasome - p. 45 12. Chapter 5: Cellular signaling, molecular activation, and regulation of the NLRP6 inflammasome - p. 60 13. Chapter 6: Molecular regulation of NAIP/NLRC4 inflammasomes - p. 74 14. Chapter 7: Cellular signaling, molecular activation, and regulation of the AIM2 inflammasome - p. 88 15. Chapter 8: Molecular activation, cellular signaling, and regulation of the Pyrin inflammasome - p. 103 16. Chapter 9: Cellular signaling, molecular activation, and regulation of the noncanonical inflammasome - p. 121 17. Chapter 10: Cellular signaling, molecular activation, and regulation of auto-active inflammasomes: Insights from disease-associated variants - p. 134 18. Chapter 11: Autophagy and the inflammasome - p. 156 19. Chapter 12: Inflammasome effector functions: a Tale of Fire and Ice - p. 169 20. Chapter 13: Inflammatory caspases - p. 193 21. Chapter 14: Structural aspects of inflammasomes forming NOD-like receptors - p. 212 22. Chapter 15: Evolutive aspects of inflammasomes - p. 231 23. Section 2: Inflammasome role in disease processes - p. 242 24. Chapter 16: The inflammasome in cardiovascular diseases - p. 242 25. Chapter 17: Inflammasome implications in metabolic disorders - p. 259 26. Chapter 18: The inflammasome in stroke - p. 270 27. Chapter 19: Inflammasome and neurodegenerative diseases - p. 287 28. Chapter 20: Inflammasomes in cigarette smoke- or ozone-induced lung diseases - p. 317 29. Chapter 21: Inflammasomes and their regulation in oral diseases - p. 335 30. Chapter 22: Inflammasome-induced inflammation and fibrosis in liver - p. 350 31. Chapter 23: Inflammasomes in sepsis - p. 364 32. Chapter 24: The Inflammasome in viral, bacterial, and fungal infections - p. 378 33. Chapter 25: Autoinflammatory disorders - p. 390 34. Chapter 26: The inflammasome in graft-versus-host disease - p. 416 35. Chapter 27: Canonical and noncanonical Inflammasomes in kidney disease - p. 423 36. Chapter 28: Inflammasomes and cancer - p. 436 37. Chapter 29: Inflammasomes in the pathobiology of degenerative retinopathies - p. 459 38. Section 3: Inflammasome cross talk in cell death - p. 475 39. Chapter 30: Regulation of pyroptosis by inflammasomes - p. 475 40. Chapter 31: Crosstalk between necroptosis and the inflammasome - p. 494 41. Chapter 32: Apoptosis and inflammasome regulation - p. 507 42. Chapter 33: Inflammasomes as integral components of PANoptosomes in the regulation of cell death - p. 519 43. Chapter 34: Regulation of neutrophil NETosis by inflammasome - p. 534 44. Section 4: Therapeutic opportunities - p. 549 45. Chapter 35: Therapeutic opportunities targeting the NLRP3 inflammasome - p. 549 46. Chapter 36: Development of selective NLRP3 inflammasome inhibitors - p. 561 47. Chapter 37: Therapeutic targeting of inflammasome signaling by blocking interleukin-1 - p. 580 48. Chapter 38: Multiinflammasome inhibitors - p. 594 49. Index - p. 617
