Despite considerable technological advances, the pharmaceutical industry is experiencing a severe innovation deficit, especially in the discovery of new drugs. Innovative Approaches in Drug Discovery: Ethnopharmacology, Systems Biology and Holistic Targeting provides a critical review and analysis of health, disease and medicine, and explores possible reasons behind the present crisis in drug discovery. The authors illustrate the benefits of systems biology and pharmacogenomics approaches, and advocate the expansion from disease-centric discovery to person-centric therapeutics involving holistic, multi-target, whole systems approaches. This book lays a path for reigniting pharmaceutical innovation through a disciplined reemergence of pharmacognosy, embracing open innovation models and collaborative, trusted public-private partnerships. With unprecedented advances made in the development of biomedically-relevant tools and technologies, the need is great and the time is now for a renewed commitment towards expanding the repertoire of medicines. By incorporating real-life examples and state-of-the-art reviews, this book provides valuable insights into the discovery and development strategies for professionals, academicians, and students in the pharmaceutical sciences.
1. Cover image - p. Cover 2. Title page - p. iii 3. Table of Contents - p. iii 4. Copyright - p. iv 5. About the Editors - p. xiii 6. About the Authors - p. xv 7. Foreword - p. xxv 8. Preface - p. xxix 9. Dedication - p. xxxvii 10. Chapter 1. Drug Discovery Impasse: Pharmacognosy Holds the Key - p. 1 11. Chapter 2. Why and How Drugs Fail - p. 23 12. Chapter 3. Holistic Drug Targeting - p. 65 13. Chapter 4. Reverse Pharmacology - p. 89 14. Chapter 5. Network Pharmacology - p. 127 15. Chapter 6. Genomics-Driven Drug Discovery Process - p. 165 16. Chapter 7. Pharmacogenomics - p. 195 17. Chapter 8. Transcriptomics and Epigenomics - p. 235 18. Chapter 9. Proteomics - p. 273 19. Chapter 10. Chemical Informatics - p. 295 20. Chapter 11. Vaccines and Immunodrugs Discovery - p. 315 21. Chapter 12. Curcumin, the Holistic Avant-Garde - p. 343 22. Chapter 13. Safety of Traditional Medicines - p. 351 23. Chapter 14. Holistic Lifestyle - p. 367 24. Chapter 15. Collaborative Strategies for Future Drug Discovery - p. 387 25. Chapter 16. Righting the Ship: The Data Reproducibility Conundrum - p. 411 26. Index - p. 429
Despite considerable technological advances, the pharmaceutical industry is experiencing a severe innovation deficit, especially in the discovery of new drugs. Innovative Approaches in Drug Discovery: Ethnopharmacology, Systems Biology and Holistic Targeting provides a critical review and analysis of health, disease and medicine, and explores possible reasons behind the present crisis in drug discovery. The authors illustrate the benefits of systems biology and pharmacogenomics approaches, and advocate the expansion from disease-centric discovery to person-centric therapeutics involving holistic, multi-target, whole systems approaches. This book lays a path for reigniting pharmaceutical innovation through a disciplined reemergence of pharmacognosy, embracing open innovation models and collaborative, trusted public-private partnerships. With unprecedented advances made in the development of biomedically-relevant tools and technologies, the need is great and the time is now for a renewed commitment towards expanding the repertoire of medicines. By incorporating real-life examples and state-of-the-art reviews, this book provides valuable insights into the discovery and development strategies for professionals, academicians, and students in the pharmaceutical sciences.
1. Cover image - p. Cover 2. Title page - p. iii 3. Table of Contents - p. iii 4. Copyright - p. iv 5. About the Editors - p. xiii 6. About the Authors - p. xv 7. Foreword - p. xxv 8. Preface - p. xxix 9. Dedication - p. xxxvii 10. Chapter 1. Drug Discovery Impasse: Pharmacognosy Holds the Key - p. 1 11. Chapter 2. Why and How Drugs Fail - p. 23 12. Chapter 3. Holistic Drug Targeting - p. 65 13. Chapter 4. Reverse Pharmacology - p. 89 14. Chapter 5. Network Pharmacology - p. 127 15. Chapter 6. Genomics-Driven Drug Discovery Process - p. 165 16. Chapter 7. Pharmacogenomics - p. 195 17. Chapter 8. Transcriptomics and Epigenomics - p. 235 18. Chapter 9. Proteomics - p. 273 19. Chapter 10. Chemical Informatics - p. 295 20. Chapter 11. Vaccines and Immunodrugs Discovery - p. 315 21. Chapter 12. Curcumin, the Holistic Avant-Garde - p. 343 22. Chapter 13. Safety of Traditional Medicines - p. 351 23. Chapter 14. Holistic Lifestyle - p. 367 24. Chapter 15. Collaborative Strategies for Future Drug Discovery - p. 387 25. Chapter 16. Righting the Ship: The Data Reproducibility Conundrum - p. 411 26. Index - p. 429
