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This issue of Interventional Cardiology Clinics, edited by Allen Jeremias, is devoted to Intravascular Physiology. Dr. Jeremias assembled a group of expert contributors to review the following topics: Evolution of Coronary Physiology – Basic Concepts of FFR and CFR; Concept of "Functional PCI" – The Rational for Physiologic Lesion Assessment for PCI Guidance; Limitations and Pitfalls of FFR and Adenosine-Induced Hyperemia; Evidence for the Use of FFR to Guide Clinical Decision-Making – The Landmark FFR Clinical Trials; Evaluation of Microvascular Disease and Clinical Outcomes; Hyperemic vs. Resting Indices for the Assessment of CAD; FFR for the Evaluation of Tandem and Bifurcations Lesions, Left Main, and Acute Coronary Syndromes; and CT-FFR: Basic Concept and Clinical Implementation.

1. Cover image - p. Cover 2. Title page - p. Cover 3. Table of Contents - p. Cover 4. Copyright - p. Cover 5. Contributors - p. Cover 6. Forthcoming Issues - p. Cover 7. Preface. Coronary Physiology: Basic Concepts and Clinical Applications - p. Cover 8. History and Development of Coronary Flow Reserve and Fractional Flow Reserve for Clinical Applications - p. Cover 9. The Concept of Functional Percutaneous Coronary Intervention: Why Physiologic Lesion Assessment Is Integral to Coronary Angiography - p. Cover 10. Limitations and Pitfalls of Fractional Flow Reserve Measurements and Adenosine-Induced Hyperemia - p. Cover 11. Landmark Fractional Flow Reserve Trials - p. Cover 12. Evaluation of Microvascular Disease and Clinical Outcomes - p. Cover 13. Can Resting Indices Obviate the Need for Hyperemia and Promote the Routine Use of Physiologically Guided Revascularization? - p. Cover 14. Fractional Flow Reserve for the Evaluation of Tandem and Bifurcation Lesions, Left Main, and Acute Coronary Syndromes - p. Cover 15. Noninvasive Fractional Flow Reserve Derived from Coronary Computed Tomography Angiography for the Diagnosis of Lesion-specific Ischemia - p. Cover 16. Association of Wall Shear Stress with Coronary Plaque Progression and Transformation - p. Cover

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This issue of Interventional Cardiology Clinics, edited by Allen Jeremias, is devoted to Intravascular Physiology. Dr. Jeremias assembled a group of expert contributors to review the following topics: Evolution of Coronary Physiology – Basic Concepts of FFR and CFR; Concept of "Functional PCI" – The Rational for Physiologic Lesion Assessment for PCI Guidance; Limitations and Pitfalls of FFR and Adenosine-Induced Hyperemia; Evidence for the Use of FFR to Guide Clinical Decision-Making – The Landmark FFR Clinical Trials; Evaluation of Microvascular Disease and Clinical Outcomes; Hyperemic vs. Resting Indices for the Assessment of CAD; FFR for the Evaluation of Tandem and Bifurcations Lesions, Left Main, and Acute Coronary Syndromes; and CT-FFR: Basic Concept and Clinical Implementation.

1. Cover image - p. Cover 2. Title page - p. Cover 3. Table of Contents - p. Cover 4. Copyright - p. Cover 5. Contributors - p. Cover 6. Forthcoming Issues - p. Cover 7. Preface. Coronary Physiology: Basic Concepts and Clinical Applications - p. Cover 8. History and Development of Coronary Flow Reserve and Fractional Flow Reserve for Clinical Applications - p. Cover 9. The Concept of Functional Percutaneous Coronary Intervention: Why Physiologic Lesion Assessment Is Integral to Coronary Angiography - p. Cover 10. Limitations and Pitfalls of Fractional Flow Reserve Measurements and Adenosine-Induced Hyperemia - p. Cover 11. Landmark Fractional Flow Reserve Trials - p. Cover 12. Evaluation of Microvascular Disease and Clinical Outcomes - p. Cover 13. Can Resting Indices Obviate the Need for Hyperemia and Promote the Routine Use of Physiologically Guided Revascularization? - p. Cover 14. Fractional Flow Reserve for the Evaluation of Tandem and Bifurcation Lesions, Left Main, and Acute Coronary Syndromes - p. Cover 15. Noninvasive Fractional Flow Reserve Derived from Coronary Computed Tomography Angiography for the Diagnosis of Lesion-specific Ischemia - p. Cover 16. Association of Wall Shear Stress with Coronary Plaque Progression and Transformation - p. Cover

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