Introductory Review on Sirtuins in Biology and Disease provides key insights for scientists and advanced students who need to understand sirtuins and the current research in this field. This book is ideal for pharmaceutical companies as they develop novel targets using sirtuins for metabolic diseases, cancer and neurodegenerative illnesses. Sirtuins are a diverse family of proteins, with several members in mammals. The functional diversity of sirtuins is rather broad, and they have been implicated in various central biological processes. Thus, they are also highly relevant in the context of various human diseases, from cancer to neurodegeneration.
1. Introduction - p. xvii 2. Chapter 1. Sirtuins, NAD+, Aging, and Disease: A Retrospective and Prospective Overview - p. 1 3. Chapter 2. Regulation of Sirtuins by Systemic NAD+ Biosynthesis - p. 7 4. Chapter 3. NAD+ Modulation: Biology and Therapy - p. 27 5. Chapter 4. The Enzymatic Activities of Sirtuins - p. 45 6. Chapter 5. Structural and Mechanistic Insights in Sirtuin Catalysis and Pharmacological Modulation - p. 63 7. Chapter 6. Pharmacological Approaches for Modulating Sirtuins - p. 71 8. Chapter 7. Reactive Acyl-CoA Species and Deacylation by the Mitochondrial Sirtuins - p. 83 9. Chapter 8. Mitochondrial Sirtuins: Coordinating Stress Responses Through Regulation of Mitochondrial Enzyme Networks - p. 95 10. Chapter 9. Multitasking Roles of the Mammalian Deacetylase SIRT6 - p. 117 11. Chapter 10. Chromatin and Nuclear Signaling: SIRT7 Function in the Nucleolus and Beyond - p. 131 12. Chapter 11. Mammalian Sirtuins, Cellular Energy Regulation, and Metabolism, and Carcinogenesis - p. 141 13. Chapter 12. Roles for Sirtuins in Cardiovascular Biology - p. 155 14. Chapter 13. Sirtuins in Brain and Neurodegenerative Disease - p. 175 15. Index - p. 197
Introductory Review on Sirtuins in Biology and Disease provides key insights for scientists and advanced students who need to understand sirtuins and the current research in this field. This book is ideal for pharmaceutical companies as they develop novel targets using sirtuins for metabolic diseases, cancer and neurodegenerative illnesses. Sirtuins are a diverse family of proteins, with several members in mammals. The functional diversity of sirtuins is rather broad, and they have been implicated in various central biological processes. Thus, they are also highly relevant in the context of various human diseases, from cancer to neurodegeneration.
1. Introduction - p. xvii 2. Chapter 1. Sirtuins, NAD+, Aging, and Disease: A Retrospective and Prospective Overview - p. 1 3. Chapter 2. Regulation of Sirtuins by Systemic NAD+ Biosynthesis - p. 7 4. Chapter 3. NAD+ Modulation: Biology and Therapy - p. 27 5. Chapter 4. The Enzymatic Activities of Sirtuins - p. 45 6. Chapter 5. Structural and Mechanistic Insights in Sirtuin Catalysis and Pharmacological Modulation - p. 63 7. Chapter 6. Pharmacological Approaches for Modulating Sirtuins - p. 71 8. Chapter 7. Reactive Acyl-CoA Species and Deacylation by the Mitochondrial Sirtuins - p. 83 9. Chapter 8. Mitochondrial Sirtuins: Coordinating Stress Responses Through Regulation of Mitochondrial Enzyme Networks - p. 95 10. Chapter 9. Multitasking Roles of the Mammalian Deacetylase SIRT6 - p. 117 11. Chapter 10. Chromatin and Nuclear Signaling: SIRT7 Function in the Nucleolus and Beyond - p. 131 12. Chapter 11. Mammalian Sirtuins, Cellular Energy Regulation, and Metabolism, and Carcinogenesis - p. 141 13. Chapter 12. Roles for Sirtuins in Cardiovascular Biology - p. 155 14. Chapter 13. Sirtuins in Brain and Neurodegenerative Disease - p. 175 15. Index - p. 197
