Isotopically-Labeled Compounds: Recent Advances and Emerging Topics in Synthesis and Applications delves into the transformative developments in isotopic labelling, a crucial field underpinning advancements in chemistry, biology, and medicine. The book emphasizes innovative methodologies for synthesizing compounds labelled with isotopes such as tritium, carbon-14, and various stable isotopes. It also discusses the tools and technologies refined over recent years to enhance analytical precision in their study. By combining theory with practical applications, it serves as an invaluable resource for researchers and professionals seeking deeper insights into isotopic synthesis and utilization.
Additionally, the book explores emerging topics, including novel applications in drug development, environmental tracing, and biochemical research. It integrates findings that push the boundaries of isotopic analysis, offering perspectives on future trends and challenges in the field.
1. Chapter 1. Introduction - p. 1 2. Chapter 2. Recent advances in deuterium and tritium chemistry - p. 5 3. Chapter 3. Carbon-14 and tritium radiolabeling of protein derivatives - p. 37 4. Chapter 4. PET and SPECT isotopes: Basic radiochemistry, new trends, and applications in molecular imaging - p. 69 5. Chapter 5. Recent developments for the synthesis of stable isotopically labeled compounds - p. 83 6. Recent developments for the synthesis of 2H-labeled compounds - p. 83 7. Carbon-13 - p. 112 8. Oxygen-17/18 - p. 129 9. Nitrogen-15 - p. 144 10. Boron-10 - p. 153 11. Sulfur-34 - p. 157 12. Chapter 6. Preclinical and clinical studies of pharmaceuticals supported by labeled compounds - p. 179 13. Chapter 7. Labeled compounds in agrochemical applications - p. 209 14. Chapter 8. Emerging fields in the chemistry of isotopes and their applications - p. 225 15. Chapter 9. Deuterated active pharmaceutical ingredients - p. 245 16. Chapter 10. Emerging green and sustainable strategies for isotope labeling - p. 277 17. Introduction - p. 277 18. Late-stage isotope labeling and skeletal editing - p. 280 19. Catalysis - p. 287 20. Greener reaction media - p. 309 21. Catalyst- and solvent-free approaches - p. 318 22. Isotope labeling using alternative energy sources - p. 332 23. Green and sustainability metrics of isotope labeling - p. 341 24. Abbreviations - p. 353 25. Index - p. 389
Isotopically-Labeled Compounds: Recent Advances and Emerging Topics in Synthesis and Applications delves into the transformative developments in isotopic labelling, a crucial field underpinning advancements in chemistry, biology, and medicine. The book emphasizes innovative methodologies for synthesizing compounds labelled with isotopes such as tritium, carbon-14, and various stable isotopes. It also discusses the tools and technologies refined over recent years to enhance analytical precision in their study. By combining theory with practical applications, it serves as an invaluable resource for researchers and professionals seeking deeper insights into isotopic synthesis and utilization.
Additionally, the book explores emerging topics, including novel applications in drug development, environmental tracing, and biochemical research. It integrates findings that push the boundaries of isotopic analysis, offering perspectives on future trends and challenges in the field.
1. Chapter 1. Introduction - p. 1 2. Chapter 2. Recent advances in deuterium and tritium chemistry - p. 5 3. Chapter 3. Carbon-14 and tritium radiolabeling of protein derivatives - p. 37 4. Chapter 4. PET and SPECT isotopes: Basic radiochemistry, new trends, and applications in molecular imaging - p. 69 5. Chapter 5. Recent developments for the synthesis of stable isotopically labeled compounds - p. 83 6. Recent developments for the synthesis of 2H-labeled compounds - p. 83 7. Carbon-13 - p. 112 8. Oxygen-17/18 - p. 129 9. Nitrogen-15 - p. 144 10. Boron-10 - p. 153 11. Sulfur-34 - p. 157 12. Chapter 6. Preclinical and clinical studies of pharmaceuticals supported by labeled compounds - p. 179 13. Chapter 7. Labeled compounds in agrochemical applications - p. 209 14. Chapter 8. Emerging fields in the chemistry of isotopes and their applications - p. 225 15. Chapter 9. Deuterated active pharmaceutical ingredients - p. 245 16. Chapter 10. Emerging green and sustainable strategies for isotope labeling - p. 277 17. Introduction - p. 277 18. Late-stage isotope labeling and skeletal editing - p. 280 19. Catalysis - p. 287 20. Greener reaction media - p. 309 21. Catalyst- and solvent-free approaches - p. 318 22. Isotope labeling using alternative energy sources - p. 332 23. Green and sustainability metrics of isotope labeling - p. 341 24. Abbreviations - p. 353 25. Index - p. 389
