Joint and Bone: From Bench to Bedside, Volume Three, the latest release in the Stem Cell Innovation in Health and Disease series, is a timely and fascinating collection of information and new discoveries that provides a contemporary snapshot album from the fast-moving field of regenerative medicine and stem cell therapeutics. This new volume addresses the molecular players underlying iPSC formation, maintenance, and expansion and differentiation, bringing chapters that describe cutting-edge research for understanding stem cell functions in joint and bone diseases, and for developing methods to bring stem cells from bench to bedside.
Each chapter includes insights ranging from the use of mouse and human organoid cultures, genetic editing in vitro and in vivo, and human iPSCs to study stem cell functions and model joint and bone diseases.
1. Introduction - p. xxv 2. Chapter 1. Cutting edge research on stem cell applications in joint, cartilage, and bone repair and regeneration - p. 1 3. Chapter 2. Stem cell-based organoid culture system as an innovative model of osteoarthritis and other joint/bone diseases - p. 23 4. Chapter 3. Contributions of stem cell engineering to new therapies for joint and bone diseases - p. 35 5. Chapter 4. Roles of innovative genome editing technologies in stem cell engineering, rheumatic diseases and other joint/bone diseases - p. 53 6. Chapter 5. Therapies related to mesenchymal stem cells for cartilage, joint, and bone diseases - p. 79 7. Chapter 6. Application potentials of the iPSC technology in modeling, drug discovery and regeneration of skeletal system disorders - p. 117 8. Chapter 7. Advances in animal models for bone and joint diseases - p. 141 9. Chapter 8. Novel biomaterials for stem cell engineering and bone regeneration - p. 169 10. Chapter 9. Stem cell innovation in bone and joint health and diseases: general conclusions, challenges and prospectives - p. 205 11. Index - p. 213
Joint and Bone: From Bench to Bedside, Volume Three, the latest release in the Stem Cell Innovation in Health and Disease series, is a timely and fascinating collection of information and new discoveries that provides a contemporary snapshot album from the fast-moving field of regenerative medicine and stem cell therapeutics. This new volume addresses the molecular players underlying iPSC formation, maintenance, and expansion and differentiation, bringing chapters that describe cutting-edge research for understanding stem cell functions in joint and bone diseases, and for developing methods to bring stem cells from bench to bedside.
Each chapter includes insights ranging from the use of mouse and human organoid cultures, genetic editing in vitro and in vivo, and human iPSCs to study stem cell functions and model joint and bone diseases.
1. Introduction - p. xxv 2. Chapter 1. Cutting edge research on stem cell applications in joint, cartilage, and bone repair and regeneration - p. 1 3. Chapter 2. Stem cell-based organoid culture system as an innovative model of osteoarthritis and other joint/bone diseases - p. 23 4. Chapter 3. Contributions of stem cell engineering to new therapies for joint and bone diseases - p. 35 5. Chapter 4. Roles of innovative genome editing technologies in stem cell engineering, rheumatic diseases and other joint/bone diseases - p. 53 6. Chapter 5. Therapies related to mesenchymal stem cells for cartilage, joint, and bone diseases - p. 79 7. Chapter 6. Application potentials of the iPSC technology in modeling, drug discovery and regeneration of skeletal system disorders - p. 117 8. Chapter 7. Advances in animal models for bone and joint diseases - p. 141 9. Chapter 8. Novel biomaterials for stem cell engineering and bone regeneration - p. 169 10. Chapter 9. Stem cell innovation in bone and joint health and diseases: general conclusions, challenges and prospectives - p. 205 11. Index - p. 213
