Extensively revised from cover to cover, Kendig and Wilmott's Disorders of the Respiratory Tract in Children, 10th Edition, continues to be your #1 choice for reliable, up-to-date information on all aspects of pediatric respiratory disorders. This highly respected reference is accessible to specialists and primary care providers alike, with coverage of both common and less common respiratory problems found in the newborn and child. Detailed and thorough, this edition covers basic science and its relevance to today’s clinical issues as well as treatment, management, and outcomes information, making it an ideal resource for day-to-day practice as well as certification or recertification review and other professional examinations such as pHERMES.
Offers an international perspective on the whole spectrum of the specialty, including a robust video library with demonstrations of key procedures and bronchoscopic views.
Uses a consistent format with succinct, bulleted text, and contains abundant tables and figures, chapter summaries, and more than 500 full-color images to convey key information in an easy-to-digest manner.
Contains eleven new chapters and discusses timely topics such as big data and -omics in respiratory disease, COVID-19, obesity and its consequences, and vaping and nicotine addiction among children and young people.
Provides up-to-date instruction on key procedures, such as bronchoscopy and pulmonary function testing.
Highlights the knowledge and expertise of nearly 90 new authors who are global experts in the fields of pediatrics, pulmonology, neurology, microbiology, cardiology, physiology, diagnostic imaging, critical care, otolaryngology, allergy, and surgery.
1. Cover image - p. Cover 2. Title page - p. ii 3. Table of Contents - p. iii 4. Copyright - p. iii 5. List of Contributors - p. iii 6. Preface - p. iii 7. Section 1: Scientific Basis of Pediatric Pulmonology - p. iii 8. List of Tables - p. iii 9. Chapter 1: Molecular and Cellular Determinants of Lung Morphogenesis - p. iii 10. Chapter 2: Basic Genetics and Epigenetics of Childhood Lung Disease - p. 14 11. Chapter 3: Big Data and Omics in Respiratory Diseases: An Analytical Perspective - p. 26 12. Chapter 4: The Surfactant System - p. 32 13. Chapter 5: The Structural and Physiologic Basis of Respiratory Disease - p. 39 14. Chapter 6: Biology and Assessment of Airway Inflammation - p. 75 15. Chapter 7: Lung Defenses: Intrinsic, Innate, and Adaptive - p. 94 16. Section 2: Clinical Tools of Pediatric Pulmonology - p. 111 17. Chapter 8: History, Physical Examination, and Strategies for Remote Monitoring - p. 111 18. Chapter 9: Bronchoscopy and Bronchoalveolar Lavage in Pediatric Patients - p. 121 19. Chapter 10: Diagnostic Imaging of the Respiratory Tract - p. 139 20. Chapter 11: Pulmonary Function Tests in Infants and Preschool Children - p. 169 21. Chapter 12: Exercise, Physical Activity, and Respiratory Health and Disease in Pediatrics - p. 180 22. Chapter 13: Integrating Patient-Reported Outcomes Into Research and Clinical Practice: Measures of Health-Related Quality of Life and Mental Health - p. 199 23. Chapter 14: Aerosol Therapy in Children - p. 216 24. Chapter 15: Physical Therapies in Pediatric Respiratory Disease - p. 230 25. Chapter 16: Children Dependent on Respiratory Support: Invasive and Non-Invasive Ventilation - p. 251 26. Chapter 17: Microbiological Diagnosis of Respiratory Illness - p. 265 27. Chapter 18: Transition From Pediatric to Adult Care - p. 276 28. Chapter 19: Long-Term Consequences of Childhood Respiratory Disease - p. 283 29. Chapter 20: Pediatric Lung Transplantation - p. 297 30. Section 3: Neonatal Pediatric Pulmonology - p. 309 31. Chapter 21: Congenital Lung Disease - p. 309 32. Chapter 22: Respiratory Disorders in the Newborn - p. 361 33. Chapter 23: Bronchopulmonary Dysplasia - p. 388 34. Section 4: Respiratory Infections - p. 403 35. Chapter 24: Acute Infections That Produce Upper Airway Obstruction - p. 403 36. Chapter 25: Bronchiolitis - p. 418 37. Chapter 26: Pneumonia in Children - p. 426 38. Chapter 27: New and Emerging Viral Infections of the Lung; Focus on SARS-CoV-2 - p. 439 39. Chapter 28: Tuberculosis - p. 448 40. Chapter 29: Nontuberculous Mycobacterial Disease - p. 470 41. Chapter 30: The Mycoses - p. 480 42. Chapter 31: Pertussis and Other Bordetella Infections of the Respiratory Tract - p. 500 43. Chapter 32: Toxocariasis, Hydatid Disease of the Lung, Strongyloidiasis, and Pulmonary Paragonimiasis - p. 507 44. Section 5: Asthma and Other Wheezing Disorders - p. 521 45. Chapter 33: Epidemiology of Childhood Asthma - p. 521 46. Chapter 34: The Immunopathogenesis of Asthma - p. 531 47. Chapter 35: Asthma in the Preschool-Age Child - p. 542 48. Chapter 36: Wheezing in Older Children: Asthma - p. 552 49. Chapter 37: Severe Asthma - p. 587 50. Section 6: Cystic Fibrosis and Other Causes of Chronic Airway Infection - p. 602 51. Chapter 38: Genetics and Pathophysiology of Cystic Fibrosis - p. 602 52. Chapter 39: Diagnosis and Presentation of Cystic Fibrosis - p. 615 53. Chapter 40: Pulmonary Disease in Cystic Fibrosis - p. 622 54. Chapter 41: Nonpulmonary Manifestations of Cystic Fibrosis - p. 635 55. Chapter 42: Modern Molecular Therapies for Cystic Fibrosis - p. 646 56. Chapter 43: Primary Ciliary Dyskinesia and Other Ciliopathies - p. 656 57. Chapter 44: Bronchiectasis and Chronic Suppurative Lung Disease - p. 668 58. Section 7: Diffuse Lung Disease - p. 693 59. Chapter 45: New Concepts in Children’s Interstitial and Diffuse Lung Disease - p. 693 60. Chapter 46: Rare and Newly Recognized Childhood Lung Disorders - p. 699 61. Chapter 47: Childhood Interstitial Lung Disease More Prevalent in Infancy - p. 705 62. Chapter 48: Lung Diseases Associated With Disruption of Pulmonary Surfactant Homeostasis - p. 715 63. Chapter 49: Pulmonary Involvement in the Systemic Inflammatory Diseases of Childhood - p. 728 64. Chapter 50: Lung Injury Caused by Pharmacologic Agents - p. 757 65. Chapter 51: Diffuse Alveolar Hemorrhage in Children - p. 768 66. Chapter 52: Hypersensitivity Pneumonitis and Eosinophilic Lung Diseases - p. 778 67. Section 8: Respiratory Complications in the Immunocompromised Child - p. 786 68. Chapter 53: Primary Immunodeficiency and Other Diseases With Immune Dysregulation - p. 786 69. Chapter 54: Pulmonary Disease in the Immunosuppressed Pediatric Patient - p. 799 70. Chapter 55: Respiratory Disorders in Children and Adolescents Living With HIV - p. 818 71. Section 9: Pulmonary Vascular Disease - p. 831 72. Chapter 56: Pulmonary Embolism and Thromboembolic Diseases - p. 831 73. Chapter 57: Childhood Pulmonary Arterial Hypertension - p. 842 74. Chapter 58: Pulmonary Arteriovenous Malformations - p. 866 75. Chapter 59: Pulmonary Lymphatic Disease - p. 871 76. Section 10: The Aerodigestive Model - p. 883 77. Chapter 60: The Aerodigestive Model: Improving Health Care for Complex Patients - p. 883 78. Chapter 61: Aspiration, Feeding, and Swallowing Disorders - p. 887 79. Chapter 62: Gastroesophageal Reflux Disease and Eosinophilic Esophagitis in Children With Complex Airway Disease - p. 904 80. Chapter 63: Laryngeal and Tracheal Airway Disorders - p. 907 81. Section 11: Disorders of Paediatric Sleep and Control of Breathing - p. 916 82. Chapter 64: Basic Physiological Principles of Sleep and Respiratory Control in Infants and Children - p. 916 83. Chapter 65: Testing for Sleep-Disordered Breathing - p. 926 84. Chapter 66: Obstructive Sleep Apnea in Children - p. 938 85. Chapter 67: Complex Sleep and Hypoventilation Disorders in Children - p. 945 86. Chapter 68: Sudden Infant Death Syndrome, Brief Resolved Unexplained Events and Apparent Life-Threatening Events, and Apnea of Prematurity - p. 960 87. Section 12: The Critically Ill Child - p. 981 88. Chapter 69: Principles of Mechanical Ventilation - p. 981 89. Chapter 70: Pediatric Acute Respiratory Distress Syndrome - p. 996 90. Chapter 71: Pulmonary Edema - p. 1006 91. Chapter 72: Lung Injury From Hydrocarbon Aspiration and Smoke Inhalation - p. 1020 92. Chapter 73: Drowning - p. 1028 93. Chapter 74: Trauma of the Thorax - p. 1033 94. Chapter 75: Respiratory Complications of Intensive Care - p. 1043 95. Section 13: Miscellaneous Pulmonary Disorders - p. 1052 96. Chapter 76: Pulmonary Disease Associated With Congenital Heart Disease - p. 1052 97. Chapter 77: The Lung in Sickle Cell Disease - p. 1067 98. Chapter 78: Respiratory Complications of Down Syndrome and Other Genetic Syndromes - p. 1075 99. Chapter 79: Tumors of the Chest - p. 1091 100. Chapter 80: Respiratory Aspects of Neuromuscular Disorders - p. 1112 101. Chapter 81: Air and Fluid in the Pleural Space, and Atelectasis - p. 1122 102. Section 14: Emerging Threats to Children’s Lung Health - p. 1145 103. Chapter 82: Environmental Contributions to Respiratory Disease in Children - p. 1145 104. Chapter 83: Combustible and Electronic Cigarettes: Tobacco and Marijuana Use in Children and Adolescents - p. 1158 105. Index - p. 1164
Extensively revised from cover to cover, Kendig and Wilmott's Disorders of the Respiratory Tract in Children, 10th Edition, continues to be your #1 choice for reliable, up-to-date information on all aspects of pediatric respiratory disorders. This highly respected reference is accessible to specialists and primary care providers alike, with coverage of both common and less common respiratory problems found in the newborn and child. Detailed and thorough, this edition covers basic science and its relevance to today’s clinical issues as well as treatment, management, and outcomes information, making it an ideal resource for day-to-day practice as well as certification or recertification review and other professional examinations such as pHERMES.
Offers an international perspective on the whole spectrum of the specialty, including a robust video library with demonstrations of key procedures and bronchoscopic views.
Uses a consistent format with succinct, bulleted text, and contains abundant tables and figures, chapter summaries, and more than 500 full-color images to convey key information in an easy-to-digest manner.
Contains eleven new chapters and discusses timely topics such as big data and -omics in respiratory disease, COVID-19, obesity and its consequences, and vaping and nicotine addiction among children and young people.
Provides up-to-date instruction on key procedures, such as bronchoscopy and pulmonary function testing.
Highlights the knowledge and expertise of nearly 90 new authors who are global experts in the fields of pediatrics, pulmonology, neurology, microbiology, cardiology, physiology, diagnostic imaging, critical care, otolaryngology, allergy, and surgery.
1. Cover image - p. Cover 2. Title page - p. ii 3. Table of Contents - p. iii 4. Copyright - p. iii 5. List of Contributors - p. iii 6. Preface - p. iii 7. Section 1: Scientific Basis of Pediatric Pulmonology - p. iii 8. List of Tables - p. iii 9. Chapter 1: Molecular and Cellular Determinants of Lung Morphogenesis - p. iii 10. Chapter 2: Basic Genetics and Epigenetics of Childhood Lung Disease - p. 14 11. Chapter 3: Big Data and Omics in Respiratory Diseases: An Analytical Perspective - p. 26 12. Chapter 4: The Surfactant System - p. 32 13. Chapter 5: The Structural and Physiologic Basis of Respiratory Disease - p. 39 14. Chapter 6: Biology and Assessment of Airway Inflammation - p. 75 15. Chapter 7: Lung Defenses: Intrinsic, Innate, and Adaptive - p. 94 16. Section 2: Clinical Tools of Pediatric Pulmonology - p. 111 17. Chapter 8: History, Physical Examination, and Strategies for Remote Monitoring - p. 111 18. Chapter 9: Bronchoscopy and Bronchoalveolar Lavage in Pediatric Patients - p. 121 19. Chapter 10: Diagnostic Imaging of the Respiratory Tract - p. 139 20. Chapter 11: Pulmonary Function Tests in Infants and Preschool Children - p. 169 21. Chapter 12: Exercise, Physical Activity, and Respiratory Health and Disease in Pediatrics - p. 180 22. Chapter 13: Integrating Patient-Reported Outcomes Into Research and Clinical Practice: Measures of Health-Related Quality of Life and Mental Health - p. 199 23. Chapter 14: Aerosol Therapy in Children - p. 216 24. Chapter 15: Physical Therapies in Pediatric Respiratory Disease - p. 230 25. Chapter 16: Children Dependent on Respiratory Support: Invasive and Non-Invasive Ventilation - p. 251 26. Chapter 17: Microbiological Diagnosis of Respiratory Illness - p. 265 27. Chapter 18: Transition From Pediatric to Adult Care - p. 276 28. Chapter 19: Long-Term Consequences of Childhood Respiratory Disease - p. 283 29. Chapter 20: Pediatric Lung Transplantation - p. 297 30. Section 3: Neonatal Pediatric Pulmonology - p. 309 31. Chapter 21: Congenital Lung Disease - p. 309 32. Chapter 22: Respiratory Disorders in the Newborn - p. 361 33. Chapter 23: Bronchopulmonary Dysplasia - p. 388 34. Section 4: Respiratory Infections - p. 403 35. Chapter 24: Acute Infections That Produce Upper Airway Obstruction - p. 403 36. Chapter 25: Bronchiolitis - p. 418 37. Chapter 26: Pneumonia in Children - p. 426 38. Chapter 27: New and Emerging Viral Infections of the Lung; Focus on SARS-CoV-2 - p. 439 39. Chapter 28: Tuberculosis - p. 448 40. Chapter 29: Nontuberculous Mycobacterial Disease - p. 470 41. Chapter 30: The Mycoses - p. 480 42. Chapter 31: Pertussis and Other Bordetella Infections of the Respiratory Tract - p. 500 43. Chapter 32: Toxocariasis, Hydatid Disease of the Lung, Strongyloidiasis, and Pulmonary Paragonimiasis - p. 507 44. Section 5: Asthma and Other Wheezing Disorders - p. 521 45. Chapter 33: Epidemiology of Childhood Asthma - p. 521 46. Chapter 34: The Immunopathogenesis of Asthma - p. 531 47. Chapter 35: Asthma in the Preschool-Age Child - p. 542 48. Chapter 36: Wheezing in Older Children: Asthma - p. 552 49. Chapter 37: Severe Asthma - p. 587 50. Section 6: Cystic Fibrosis and Other Causes of Chronic Airway Infection - p. 602 51. Chapter 38: Genetics and Pathophysiology of Cystic Fibrosis - p. 602 52. Chapter 39: Diagnosis and Presentation of Cystic Fibrosis - p. 615 53. Chapter 40: Pulmonary Disease in Cystic Fibrosis - p. 622 54. Chapter 41: Nonpulmonary Manifestations of Cystic Fibrosis - p. 635 55. Chapter 42: Modern Molecular Therapies for Cystic Fibrosis - p. 646 56. Chapter 43: Primary Ciliary Dyskinesia and Other Ciliopathies - p. 656 57. Chapter 44: Bronchiectasis and Chronic Suppurative Lung Disease - p. 668 58. Section 7: Diffuse Lung Disease - p. 693 59. Chapter 45: New Concepts in Children’s Interstitial and Diffuse Lung Disease - p. 693 60. Chapter 46: Rare and Newly Recognized Childhood Lung Disorders - p. 699 61. Chapter 47: Childhood Interstitial Lung Disease More Prevalent in Infancy - p. 705 62. Chapter 48: Lung Diseases Associated With Disruption of Pulmonary Surfactant Homeostasis - p. 715 63. Chapter 49: Pulmonary Involvement in the Systemic Inflammatory Diseases of Childhood - p. 728 64. Chapter 50: Lung Injury Caused by Pharmacologic Agents - p. 757 65. Chapter 51: Diffuse Alveolar Hemorrhage in Children - p. 768 66. Chapter 52: Hypersensitivity Pneumonitis and Eosinophilic Lung Diseases - p. 778 67. Section 8: Respiratory Complications in the Immunocompromised Child - p. 786 68. Chapter 53: Primary Immunodeficiency and Other Diseases With Immune Dysregulation - p. 786 69. Chapter 54: Pulmonary Disease in the Immunosuppressed Pediatric Patient - p. 799 70. Chapter 55: Respiratory Disorders in Children and Adolescents Living With HIV - p. 818 71. Section 9: Pulmonary Vascular Disease - p. 831 72. Chapter 56: Pulmonary Embolism and Thromboembolic Diseases - p. 831 73. Chapter 57: Childhood Pulmonary Arterial Hypertension - p. 842 74. Chapter 58: Pulmonary Arteriovenous Malformations - p. 866 75. Chapter 59: Pulmonary Lymphatic Disease - p. 871 76. Section 10: The Aerodigestive Model - p. 883 77. Chapter 60: The Aerodigestive Model: Improving Health Care for Complex Patients - p. 883 78. Chapter 61: Aspiration, Feeding, and Swallowing Disorders - p. 887 79. Chapter 62: Gastroesophageal Reflux Disease and Eosinophilic Esophagitis in Children With Complex Airway Disease - p. 904 80. Chapter 63: Laryngeal and Tracheal Airway Disorders - p. 907 81. Section 11: Disorders of Paediatric Sleep and Control of Breathing - p. 916 82. Chapter 64: Basic Physiological Principles of Sleep and Respiratory Control in Infants and Children - p. 916 83. Chapter 65: Testing for Sleep-Disordered Breathing - p. 926 84. Chapter 66: Obstructive Sleep Apnea in Children - p. 938 85. Chapter 67: Complex Sleep and Hypoventilation Disorders in Children - p. 945 86. Chapter 68: Sudden Infant Death Syndrome, Brief Resolved Unexplained Events and Apparent Life-Threatening Events, and Apnea of Prematurity - p. 960 87. Section 12: The Critically Ill Child - p. 981 88. Chapter 69: Principles of Mechanical Ventilation - p. 981 89. Chapter 70: Pediatric Acute Respiratory Distress Syndrome - p. 996 90. Chapter 71: Pulmonary Edema - p. 1006 91. Chapter 72: Lung Injury From Hydrocarbon Aspiration and Smoke Inhalation - p. 1020 92. Chapter 73: Drowning - p. 1028 93. Chapter 74: Trauma of the Thorax - p. 1033 94. Chapter 75: Respiratory Complications of Intensive Care - p. 1043 95. Section 13: Miscellaneous Pulmonary Disorders - p. 1052 96. Chapter 76: Pulmonary Disease Associated With Congenital Heart Disease - p. 1052 97. Chapter 77: The Lung in Sickle Cell Disease - p. 1067 98. Chapter 78: Respiratory Complications of Down Syndrome and Other Genetic Syndromes - p. 1075 99. Chapter 79: Tumors of the Chest - p. 1091 100. Chapter 80: Respiratory Aspects of Neuromuscular Disorders - p. 1112 101. Chapter 81: Air and Fluid in the Pleural Space, and Atelectasis - p. 1122 102. Section 14: Emerging Threats to Children’s Lung Health - p. 1145 103. Chapter 82: Environmental Contributions to Respiratory Disease in Children - p. 1145 104. Chapter 83: Combustible and Electronic Cigarettes: Tobacco and Marijuana Use in Children and Adolescents - p. 1158 105. Index - p. 1164
