Kidney Transplantation, Bioengineering, and Regeneration: Kidney Transplantation in the Regenerative Medicine Era investigates how the field of regenerative medicine is changing the traditional premises of solid organ transplantation, specifically within the field of kidney transplantation. In Section 1, chapters illustrate the state of the art in kidney transplantation as well as the research behind the bioengineering and regeneration of kidney organoids for therapeutic renal replacement.
In Section II, chapters catalog the technologies that are being developed and the methods that are being implemented to bioengineer or regenerate kidneys in order to restore function, while critically highlighting those technological advances which hold the most promise. The book thus encompasses clinical renal transplantation, tissue engineering, biomaterial sciences, stem cell biology, and developmental biology, as they are all applied to the kidney.
1. Section I: Introduction - p. 749 2. Chapter 54. Converging Organ Transplantation Towards Regenerative Medicine - p. 757 3. Chapter 55. A Systems Engineering Approach to Restoring Kidney Structure and Function - p. 769 4. Section II: Kidney Development - p. 782 5. Chapter 56. Kidney Development in the Mammal - p. 787 6. Chapter 57. Renal Branching Morphogenesis - p. 801 7. Section III: Bioengineering - p. 811 8. Chapter 58. Principles of Stem Cell Biology Applied to the Kidney - p. 817 9. Chapter 59. Extracellular Matrix Biology Applied to the Kidney - p. 829 10. Chapter 60. Interplay Between Growth Factor Receptors, Small GTPases, and Mechanical Stress in the Maintenance of Kidney Glomerular Homeostasis - p. 843 11. Chapter 61. Bioengineering Approach to Immunomodulation - p. 861 12. Chapter 62. Principles of Organ Bioengineering - p. 873 13. Chapter 63. Recellularization of Kidney Scaffold With Stem Cells - p. 877 14. Section IV: Bioreactors and Biomaterials - p. 884 15. Chapter 64. Bioreactors for Cell Culture Systems and Organ Bioengineering - p. 889 16. Chapter 65. Synthetic Biomaterial for Regenerative Medicine Applications - p. 901 17. Chapter 66. Immune Responses to Biomaterials Used in Renal Engineering - p. 923 18. Section V: Regeneration - p. 931 19. Chapter 67. Regeneration of Kidney From Human Reprogrammed Stem Cells - p. 937 20. Chapter 68. Bioprinting Complex 3D Tissue and Organs - p. 957 21. Chapter 69. Principles of Kidney Regeneration - p. 973 22. Chapter 70. Markers of Repair and Regeneration in the Marginal Kidney - p. 989 23. Chapter 71. Nephron Repair in Mammals and Fish - p. 997 24. Chapter 72. Imaging of Glomerular Regeneration - p. 1005 25. Chapter 73. Reversibility of Renal Fibrosis - p. 1013 26. Chapter 74. Pharmacological Induction of Kidney Regeneration - p. 1025 27. Chapter 75. Developmental Approaches to Kidney Regeneration - p. 1039 28. Section VI: Adult Cells for Regeneration - p. 1048 29. Chapter 76. Nephron Progenitors - p. 1053 30. Chapter 77. Urine Progenitor Cells for Potential Application in Renal Tissue Repair - p. 1067 31. Chapter 78. Endothelial Progenitor Cells in Kidney Disease - p. 1075 32. Section VII: Cell Therapy For Renal Tissue Repair - p. 1080 33. Chapter 79. Mesenchymal Stromal Cells for Acute Renal Injury - p. 1085 34. Chapter 80. Amniotic Fluid Cells: Kidney Injury and Regeneration - p. 1097 35. Chapter 81. Renal Cells From Spermatogonial Germline Stem Cells for Protection Against Kidney Injury - p. 1109 36. Section VIII: Future Perspective - p. 1114 37. Chapter 82. Kidney-on-a-Chip: Technologies for Studying Pharmacological and Therapeutic Approaches to Kidney Repair - p. 1119 38. Chapter 83. Renal Replacement Devices - p. 1135 39. Chapter 84. Xenotransplantation and Kidney Regenerative Technology - p. 1151 40. Chapter 85. Embryonic Organoid Transplantation - p. 1163 41. Chapter 86. Lineage Reprogramming Toward Kidney Regeneration - p. 1167 42. Chapter 87. Regenerating Kidney Structure and Function: An Industry Perspective - p. 1177 43. Index - p. 1189
Kidney Transplantation, Bioengineering, and Regeneration: Kidney Transplantation in the Regenerative Medicine Era investigates how the field of regenerative medicine is changing the traditional premises of solid organ transplantation, specifically within the field of kidney transplantation. In Section 1, chapters illustrate the state of the art in kidney transplantation as well as the research behind the bioengineering and regeneration of kidney organoids for therapeutic renal replacement.
In Section II, chapters catalog the technologies that are being developed and the methods that are being implemented to bioengineer or regenerate kidneys in order to restore function, while critically highlighting those technological advances which hold the most promise. The book thus encompasses clinical renal transplantation, tissue engineering, biomaterial sciences, stem cell biology, and developmental biology, as they are all applied to the kidney.
1. Section I: Introduction - p. 749 2. Chapter 54. Converging Organ Transplantation Towards Regenerative Medicine - p. 757 3. Chapter 55. A Systems Engineering Approach to Restoring Kidney Structure and Function - p. 769 4. Section II: Kidney Development - p. 782 5. Chapter 56. Kidney Development in the Mammal - p. 787 6. Chapter 57. Renal Branching Morphogenesis - p. 801 7. Section III: Bioengineering - p. 811 8. Chapter 58. Principles of Stem Cell Biology Applied to the Kidney - p. 817 9. Chapter 59. Extracellular Matrix Biology Applied to the Kidney - p. 829 10. Chapter 60. Interplay Between Growth Factor Receptors, Small GTPases, and Mechanical Stress in the Maintenance of Kidney Glomerular Homeostasis - p. 843 11. Chapter 61. Bioengineering Approach to Immunomodulation - p. 861 12. Chapter 62. Principles of Organ Bioengineering - p. 873 13. Chapter 63. Recellularization of Kidney Scaffold With Stem Cells - p. 877 14. Section IV: Bioreactors and Biomaterials - p. 884 15. Chapter 64. Bioreactors for Cell Culture Systems and Organ Bioengineering - p. 889 16. Chapter 65. Synthetic Biomaterial for Regenerative Medicine Applications - p. 901 17. Chapter 66. Immune Responses to Biomaterials Used in Renal Engineering - p. 923 18. Section V: Regeneration - p. 931 19. Chapter 67. Regeneration of Kidney From Human Reprogrammed Stem Cells - p. 937 20. Chapter 68. Bioprinting Complex 3D Tissue and Organs - p. 957 21. Chapter 69. Principles of Kidney Regeneration - p. 973 22. Chapter 70. Markers of Repair and Regeneration in the Marginal Kidney - p. 989 23. Chapter 71. Nephron Repair in Mammals and Fish - p. 997 24. Chapter 72. Imaging of Glomerular Regeneration - p. 1005 25. Chapter 73. Reversibility of Renal Fibrosis - p. 1013 26. Chapter 74. Pharmacological Induction of Kidney Regeneration - p. 1025 27. Chapter 75. Developmental Approaches to Kidney Regeneration - p. 1039 28. Section VI: Adult Cells for Regeneration - p. 1048 29. Chapter 76. Nephron Progenitors - p. 1053 30. Chapter 77. Urine Progenitor Cells for Potential Application in Renal Tissue Repair - p. 1067 31. Chapter 78. Endothelial Progenitor Cells in Kidney Disease - p. 1075 32. Section VII: Cell Therapy For Renal Tissue Repair - p. 1080 33. Chapter 79. Mesenchymal Stromal Cells for Acute Renal Injury - p. 1085 34. Chapter 80. Amniotic Fluid Cells: Kidney Injury and Regeneration - p. 1097 35. Chapter 81. Renal Cells From Spermatogonial Germline Stem Cells for Protection Against Kidney Injury - p. 1109 36. Section VIII: Future Perspective - p. 1114 37. Chapter 82. Kidney-on-a-Chip: Technologies for Studying Pharmacological and Therapeutic Approaches to Kidney Repair - p. 1119 38. Chapter 83. Renal Replacement Devices - p. 1135 39. Chapter 84. Xenotransplantation and Kidney Regenerative Technology - p. 1151 40. Chapter 85. Embryonic Organoid Transplantation - p. 1163 41. Chapter 86. Lineage Reprogramming Toward Kidney Regeneration - p. 1167 42. Chapter 87. Regenerating Kidney Structure and Function: An Industry Perspective - p. 1177 43. Index - p. 1189
