Laboratory Animal Medicine, Third Edition, is a fully revised publication from the American College of Laboratory Medicine’s acclaimed blue book series. It presents an uptodate volume that offers the most thorough coverage of the biology, health, and care of laboratory animals. The book is organized by species, with new inclusions of chinchillas, birds, and program and employee management, and is written and edited by known experts in the fields. Users will find goldstandard guidance on the study of laboratory animal science, as well as valuable information that applies across all of the biological and biomedical sciences that work with animals.
1. I Introduction 2. II Origins of Animal Experimentation 3. III Early Veterinarians in Laboratory Animal Science and Medicine 4. IV The Organizations of Laboratory Animal science 5. V Education and Training in Laboratory Animal Medicine 6. VI ACLAM-Sponsored Texts 7. VII Impact of Laws, Regulations, and Guidelines on Laboratory Animal Medicine 8. VIII Regulation of Animal Research in the United Kingdom and Canada 9. IX Commercial and Academic Breeding of Rodents 10. X Conclusion 11. Acknowledgment 12. References 13. I Introduction 14. II Animal Welfare 15. III Importation and Exportation of Animals and Animal Products 16. IV Hazardous Substances 17. V Nucleic Acid and Nanomaterial Research Guidelines 18. References 19. I Introduction 20. II Biology 21. III Diseases 22. References 23. I Introduction 24. II Biology 25. III Diseases 26. Acknowledgment 27. References 28. I Introduction 29. II Syrian Hamster 30. III Chinese Hamster 31. IV Armenian Hamster 32. V European Hamster 33. VI Djungarian Hamster 34. References 35. I Introduction 36. II Biology 37. III Diseases 38. References 39. I Introduction 40. II Ground Squirrels: Urocitellus, Ictodomys, and Spermophilus 41. III Prairie Dogs: Cynomys 42. IV Pocket Gophers: Geomyidae 43. V Kangaroo Rats: Dipodomys 44. VI Pack Rats: Neotoma 45. VII Grasshopper Mice: Onychomys 46. VIII Deer Mice: Peromyscus 47. IX Rice Rats: Oryzomys 48. X Cane Mice: Zygodontomys 49. XI Cotton Rats: Sigmodon 50. XII White-Tailed Rats: Mystromys 51. XIII Gerbils and Jirds: Meriones 52. XIV Voles: Microtus 53. XV Multimammate Rats/Mice: Mastomys 54. XVI Degus: Octodon 55. XVII Naked Mole Rats: Heterocephalus Glaber 56. References 57. I Introduction 58. II Biology 59. III Diseases 60. IV The Woodchuck as an Experimental Animal Model for HBV Research 61. References 62. I Introduction 63. II Biology 64. III Diseases 65. References 66. I Introduction 67. II Biology 68. III Diseases 69. References 70. I Introduction 71. II Microbiological Quality Specifications 72. III Biosecurity 73. IV Health Monitoring 74. V Outbreak Management and Investigation 75. References 76. I Introduction 77. II Biology 78. III Diseases 79. Acknowledgments 80. References 81. I Introduction 82. II Sources of Cats 83. III Housing 84. IV Breeding Colony Management 85. V Nutrition and Feeding 86. VI Infectious Disease Exclusion and Control 87. Acknowledgments 88. References 89. I Introduction 90. II Biology 91. III Diseases 92. Acknowledgment 93. References 94. I Introduction 95. II Biology 96. III Diseases 97. References 98. I Introduction 99. II Biology 100. III Diseases 101. Acronyms Used in Chapter 102. Acknowledgments 103. References 104. I Introduction 105. II Taxonomy 106. III Biology 107. IV Principles of Colony Management 108. V Medical Management 109. VI Diseases 110. Acknowledgments 111. References 112. I Introduction 113. II Biology 114. III Diseases 115. References 116. I Introduction 117. II Biology 118. III Diseases 119. References 120. I Introduction 121. II Zebrafish: The Experimental Model in Biomedical Research 122. III Significances of Healthy Management in the Aquatic Animal Facility 123. IV Environmental Factors Important to Zebrafish Health 124. V General Features of Laboratory Zebrafish Facilities 125. VI Nutrition and Feeding of Zebrafish 126. VII Pathogen Control Program 127. VIII Techniques and Anesthesia 128. IX Significant Diseases of Laboratory Zebrafish 129. Acknowledgment 130. References 131. I Introduction 132. II Facility Design 133. III Management and Husbandry 134. IV Medical Protocols 135. V Zoonotic Considerations 136. VI Diseases 137. References 138. I Introduction 139. II Biology 140. III Laboratory Management and Husbandry 141. IV Breeding and Rearing Quail 142. V Diseases/Welfare Concerns 143. References 144. I Introduction 145. II History and Taxonomy 146. III Research Uses 147. IV Biology 148. V Laboratory Management and Husbandry 149. VI Diseases/Welfare Concerns 150. References 151. I Introduction 152. II Rodents 153. III Rabbits 154. IV Ferrets 155. V Swine 156. VI Small Ruminants 157. VII Nonhuman Primates 158. References 159. I Introduction 160. II Identification Methods 161. III Blood Collection and Intravenous Injection 162. IV Vascular Cannulation 163. V Intraperitoneal Injection 164. VI Subcutaneous, Intramuscular, and Intraosseous Injection 165. VII Digestive System 166. VIII Urinary System Techniques 167. IX Respiratory System Techniques 168. X Reproductive System 169. XI Cardiovascular Techniques 170. XII Endocrine System Techniques 171. XIII Orthopedic Procedures for Laboratory Animals 172. XIV Neurosurgical Techniques 173. XV Tumor Transplantation 174. XVI Imaging Techniques 175. XVII Radiotelemetry 176. XVIII Thymectomy 177. Acknowledgments 178. References 179. I Introduction 180. II Terminology 181. III History 182. IV Characteristics of Gnotobiotes 183. V Establishing a Gnotobiotic Facility 184. VI Operation 185. VII Derivation of Germfree Mice 186. VIII. Resources 187. References 188. I Introduction 189. II Risk Assessment 190. III Managing an Animal Biocontainment Program 191. IV Standard Practices 192. V Veterinary Care 193. VI Other Considerations 194. VII Summary 195. References 196. I Introduction 197. II Viral Diseases 198. III Rickettsial Diseases 199. IV Chlamydial Infections 200. V Bacterial Diseases 201. VI Fungal Diseases 202. VII Protozoal Diseases 203. VIII Helminth Infections 204. IX Arthropod Infestations 205. Acknowledgments 206. References 207. I Introduction 208. II Lessons from Allotransplantation/Historical Perspective 209. III Potential Mechanisms for Cross-Species Infections 210. IV NonViral Agents 211. V Development of SPF Herds 212. VI Potential Benefits of Xenotransplantation and Other Infectious Disease Issues 213. VII Issues after Xenotransplantation 214. References 215. I Introduction 216. II Occupational Illness and Injury in Laboratory Animal Workers 217. III Occupational Health Approach 218. IV Hazard Identification 219. V Hazard Controls 220. VI Occupational Medicine Services 221. Appendix 30.1 222. Appendix 30.2 223. References 224. I Introduction 225. II History of Genetic Monitoring 226. III Rodent Strains: Genetic Homogeneity or Genetic Diversity 227. IV SNP Analysis: Testing Strain Background 228. V Allele-Specific Genotyping: Testing Mutant Strains 229. VI Maintaining Strains 230. VII Phenotype Quality Control 231. VIII The Future of GQC 232. IX GQC: Practical Aspects 233. X Conclusions 234. References 235. I Introduction 236. II Manipulating Animals for Genetic Modification 237. III Genetic Modification and Technologies 238. IV Colony Management for GM Mice and Rats 239. V Finding Mouse and Rat Resources 240. References 241. I Introduction 242. II Intrinsic Considerations 243. III Extrinsic Considerations 244. References 245. I Introduction 246. II What is an Animal Model? 247. III Nature of Research 248. IV History of Animal Use in Biomedical Research 249. References 250. I Introduction 251. II Principles of Experimentation 252. III Role of the Laboratory Animal Specialist in Research 253. IV Research Training 254. V Summary 255. Acknowledgment 256. References 257. I Introduction 258. II Facility Planning and Design 259. III Environmental Control and Monitoring 260. IV Housing and Equipment 261. V Materials 262. VI Operational Issues 263. VII Conclusions 264. References 265. I Introduction and Definitions 266. II Mission and Strategy: Where it All Starts 267. III Managing People 268. IV Managing Money 269. V Managing Operations 270. VI Concluding Remarks 271. Appendix 1 Executive Summary of the 14 Toyota Way Principles (Reprinted with Permission, McGraw-Hill Education Holdings, LLC, Philadelphia, PA) 272. References 273. I Introduction 274. II Rodents 275. III Rabbits 276. IV Laboratory Dogs and Cats 277. V Nonhuman Primates 278. VI Farm Animals 279. VII Conclusions 280. References 281. I Introduction 282. II Animal Welfare as a Key Component in Research, Teaching, and Testing Using Animals 283. III Animal Welfare – A Historical and Philosophical Perspective 284. IV Guidelines and Principles 285. V Strategies to Optimize Animal Welfare 286. VI Examples of Challenging Research and Opportunities for Animal Welfare Optimization 287. VII Science of Animal Welfare 288. VIII Conclusion and Summary 289. References 290. Index 291. Sync with Jellybooks
Laboratory Animal Medicine, Third Edition, is a fully revised publication from the American College of Laboratory Medicine’s acclaimed blue book series. It presents an uptodate volume that offers the most thorough coverage of the biology, health, and care of laboratory animals. The book is organized by species, with new inclusions of chinchillas, birds, and program and employee management, and is written and edited by known experts in the fields. Users will find goldstandard guidance on the study of laboratory animal science, as well as valuable information that applies across all of the biological and biomedical sciences that work with animals.
1. I Introduction 2. II Origins of Animal Experimentation 3. III Early Veterinarians in Laboratory Animal Science and Medicine 4. IV The Organizations of Laboratory Animal science 5. V Education and Training in Laboratory Animal Medicine 6. VI ACLAM-Sponsored Texts 7. VII Impact of Laws, Regulations, and Guidelines on Laboratory Animal Medicine 8. VIII Regulation of Animal Research in the United Kingdom and Canada 9. IX Commercial and Academic Breeding of Rodents 10. X Conclusion 11. Acknowledgment 12. References 13. I Introduction 14. II Animal Welfare 15. III Importation and Exportation of Animals and Animal Products 16. IV Hazardous Substances 17. V Nucleic Acid and Nanomaterial Research Guidelines 18. References 19. I Introduction 20. II Biology 21. III Diseases 22. References 23. I Introduction 24. II Biology 25. III Diseases 26. Acknowledgment 27. References 28. I Introduction 29. II Syrian Hamster 30. III Chinese Hamster 31. IV Armenian Hamster 32. V European Hamster 33. VI Djungarian Hamster 34. References 35. I Introduction 36. II Biology 37. III Diseases 38. References 39. I Introduction 40. II Ground Squirrels: Urocitellus, Ictodomys, and Spermophilus 41. III Prairie Dogs: Cynomys 42. IV Pocket Gophers: Geomyidae 43. V Kangaroo Rats: Dipodomys 44. VI Pack Rats: Neotoma 45. VII Grasshopper Mice: Onychomys 46. VIII Deer Mice: Peromyscus 47. IX Rice Rats: Oryzomys 48. X Cane Mice: Zygodontomys 49. XI Cotton Rats: Sigmodon 50. XII White-Tailed Rats: Mystromys 51. XIII Gerbils and Jirds: Meriones 52. XIV Voles: Microtus 53. XV Multimammate Rats/Mice: Mastomys 54. XVI Degus: Octodon 55. XVII Naked Mole Rats: Heterocephalus Glaber 56. References 57. I Introduction 58. II Biology 59. III Diseases 60. IV The Woodchuck as an Experimental Animal Model for HBV Research 61. References 62. I Introduction 63. II Biology 64. III Diseases 65. References 66. I Introduction 67. II Biology 68. III Diseases 69. References 70. I Introduction 71. II Microbiological Quality Specifications 72. III Biosecurity 73. IV Health Monitoring 74. V Outbreak Management and Investigation 75. References 76. I Introduction 77. II Biology 78. III Diseases 79. Acknowledgments 80. References 81. I Introduction 82. II Sources of Cats 83. III Housing 84. IV Breeding Colony Management 85. V Nutrition and Feeding 86. VI Infectious Disease Exclusion and Control 87. Acknowledgments 88. References 89. I Introduction 90. II Biology 91. III Diseases 92. Acknowledgment 93. References 94. I Introduction 95. II Biology 96. III Diseases 97. References 98. I Introduction 99. II Biology 100. III Diseases 101. Acronyms Used in Chapter 102. Acknowledgments 103. References 104. I Introduction 105. II Taxonomy 106. III Biology 107. IV Principles of Colony Management 108. V Medical Management 109. VI Diseases 110. Acknowledgments 111. References 112. I Introduction 113. II Biology 114. III Diseases 115. References 116. I Introduction 117. II Biology 118. III Diseases 119. References 120. I Introduction 121. II Zebrafish: The Experimental Model in Biomedical Research 122. III Significances of Healthy Management in the Aquatic Animal Facility 123. IV Environmental Factors Important to Zebrafish Health 124. V General Features of Laboratory Zebrafish Facilities 125. VI Nutrition and Feeding of Zebrafish 126. VII Pathogen Control Program 127. VIII Techniques and Anesthesia 128. IX Significant Diseases of Laboratory Zebrafish 129. Acknowledgment 130. References 131. I Introduction 132. II Facility Design 133. III Management and Husbandry 134. IV Medical Protocols 135. V Zoonotic Considerations 136. VI Diseases 137. References 138. I Introduction 139. II Biology 140. III Laboratory Management and Husbandry 141. IV Breeding and Rearing Quail 142. V Diseases/Welfare Concerns 143. References 144. I Introduction 145. II History and Taxonomy 146. III Research Uses 147. IV Biology 148. V Laboratory Management and Husbandry 149. VI Diseases/Welfare Concerns 150. References 151. I Introduction 152. II Rodents 153. III Rabbits 154. IV Ferrets 155. V Swine 156. VI Small Ruminants 157. VII Nonhuman Primates 158. References 159. I Introduction 160. II Identification Methods 161. III Blood Collection and Intravenous Injection 162. IV Vascular Cannulation 163. V Intraperitoneal Injection 164. VI Subcutaneous, Intramuscular, and Intraosseous Injection 165. VII Digestive System 166. VIII Urinary System Techniques 167. IX Respiratory System Techniques 168. X Reproductive System 169. XI Cardiovascular Techniques 170. XII Endocrine System Techniques 171. XIII Orthopedic Procedures for Laboratory Animals 172. XIV Neurosurgical Techniques 173. XV Tumor Transplantation 174. XVI Imaging Techniques 175. XVII Radiotelemetry 176. XVIII Thymectomy 177. Acknowledgments 178. References 179. I Introduction 180. II Terminology 181. III History 182. IV Characteristics of Gnotobiotes 183. V Establishing a Gnotobiotic Facility 184. VI Operation 185. VII Derivation of Germfree Mice 186. VIII. Resources 187. References 188. I Introduction 189. II Risk Assessment 190. III Managing an Animal Biocontainment Program 191. IV Standard Practices 192. V Veterinary Care 193. VI Other Considerations 194. VII Summary 195. References 196. I Introduction 197. II Viral Diseases 198. III Rickettsial Diseases 199. IV Chlamydial Infections 200. V Bacterial Diseases 201. VI Fungal Diseases 202. VII Protozoal Diseases 203. VIII Helminth Infections 204. IX Arthropod Infestations 205. Acknowledgments 206. References 207. I Introduction 208. II Lessons from Allotransplantation/Historical Perspective 209. III Potential Mechanisms for Cross-Species Infections 210. IV NonViral Agents 211. V Development of SPF Herds 212. VI Potential Benefits of Xenotransplantation and Other Infectious Disease Issues 213. VII Issues after Xenotransplantation 214. References 215. I Introduction 216. II Occupational Illness and Injury in Laboratory Animal Workers 217. III Occupational Health Approach 218. IV Hazard Identification 219. V Hazard Controls 220. VI Occupational Medicine Services 221. Appendix 30.1 222. Appendix 30.2 223. References 224. I Introduction 225. II History of Genetic Monitoring 226. III Rodent Strains: Genetic Homogeneity or Genetic Diversity 227. IV SNP Analysis: Testing Strain Background 228. V Allele-Specific Genotyping: Testing Mutant Strains 229. VI Maintaining Strains 230. VII Phenotype Quality Control 231. VIII The Future of GQC 232. IX GQC: Practical Aspects 233. X Conclusions 234. References 235. I Introduction 236. II Manipulating Animals for Genetic Modification 237. III Genetic Modification and Technologies 238. IV Colony Management for GM Mice and Rats 239. V Finding Mouse and Rat Resources 240. References 241. I Introduction 242. II Intrinsic Considerations 243. III Extrinsic Considerations 244. References 245. I Introduction 246. II What is an Animal Model? 247. III Nature of Research 248. IV History of Animal Use in Biomedical Research 249. References 250. I Introduction 251. II Principles of Experimentation 252. III Role of the Laboratory Animal Specialist in Research 253. IV Research Training 254. V Summary 255. Acknowledgment 256. References 257. I Introduction 258. II Facility Planning and Design 259. III Environmental Control and Monitoring 260. IV Housing and Equipment 261. V Materials 262. VI Operational Issues 263. VII Conclusions 264. References 265. I Introduction and Definitions 266. II Mission and Strategy: Where it All Starts 267. III Managing People 268. IV Managing Money 269. V Managing Operations 270. VI Concluding Remarks 271. Appendix 1 Executive Summary of the 14 Toyota Way Principles (Reprinted with Permission, McGraw-Hill Education Holdings, LLC, Philadelphia, PA) 272. References 273. I Introduction 274. II Rodents 275. III Rabbits 276. IV Laboratory Dogs and Cats 277. V Nonhuman Primates 278. VI Farm Animals 279. VII Conclusions 280. References 281. I Introduction 282. II Animal Welfare as a Key Component in Research, Teaching, and Testing Using Animals 283. III Animal Welfare – A Historical and Philosophical Perspective 284. IV Guidelines and Principles 285. V Strategies to Optimize Animal Welfare 286. VI Examples of Challenging Research and Opportunities for Animal Welfare Optimization 287. VII Science of Animal Welfare 288. VIII Conclusion and Summary 289. References 290. Index 291. Sync with Jellybooks
