Lantibiotics as Alternative Therapeutics explores alternative therapeutics, lantibiotics and other novel drugs. This book provides concrete information to readers regarding lantibiotics and various types of antimicrobial peptides with their mode of actions in treating various multidrug resistant organisms. It explains various techniques that are involved in analyzing antimicrobial peptides and their mode of actions. The development of antibiotic resistance has now reached a point of crisis where innovative methods and application of novel compounds and methods are required to prevent the spread of drug resistant infections.
Novel compounds exhibit different modes of action to the currently used mechanism of therapeutics in order to combat against the resistant organisms. Lantibiotics hold considerable potential as a consequence of their unusual structure, unique mechanisms of action and their potency against multi-drug resistant bacteria. This book will be useful for pharmaceutical industry scientists and researchers in microbial and biomedical research as well as graduate and advanced students in microbiology, medical biotechnology, health, and pharmaceutical sciences.
1. Lantibiotics as Alternative Therapeutics - p. i 2. Cover - p. i 3. Title Page - p. iii 4. Copyright Page - p. iv 5. Table of Contents - p. iv 6. List of Contributors - p. xiii 7. Preface - p. xvii 8. Chapter 1 Quandary of antibiotics and multidrug resistance development: a molecular genetics-based dilemma - p. 1 9. Chapter 2 Antimicrobial peptides and their potent mechanism of action - p. 25 10. Chapter 3 Biosynthesis of lantibiotics - p. 43 11. Chapter 4 Development of recombinant lantibiotics and their potent uses - p. 65 12. Chapter 5 Mechanism of action of the lantibiotics on the multidrug-resistant organisms - p. 85 13. Chapter 6 Lantibiotics, its role in the meat and poultry industry - p. 119 14. Chapter 7 Application of lantibiotics in canned food preservation - p. 147 15. Chapter 8 Lantibiotics and its role in dairy product preservation - p. 169 16. Chapter 9 In vitro studies on a natural lantibiotic: paenibacillin - p. 191 17. Chapter 10 Lantibiotics in antifungal therapy: a futuristic approach - p. 205 18. Chapter 11 In silico studies of interaction of lantibiotics with virulent proteins - p. 221 19. Chapter 12 Insights at the atomistic resolution of lantibiotics using multiscale simulations - p. 241 20. Chapter 13 Immunogenicity studies on lantibiotics - p. 255 21. Chapter 14 Case studies: application of lantibiotics as novel drugs - p. 277 22. Chapter 15 Recent updates in understanding of molecular genetics of lantibiotics production - p. 301 23. Chapter 16 Methods for identification of the modes of action of lantibiotics - p. 319 24. Chapter 17 Computational modeling for exploring the therapeutic repertoire of lantibiotics - p. 337 25. Chapter 18 Combinations of nanobiomolecules as next-generation antimicrobial agents - p. 353 26. Chapter 19 Lantibiotics: the way forward for clinical trials and clinical approval process - p. 377 27. Chapter 20 Properties, classification and applications of lantibiotics from Gram-positive bacteria - p. 411 28. Chapter 21 Lantibiotics production—optimization and scale-up research: cutting edge and challenges - p. 427 29. Chapter 22 Production and optimization of lantibiotics - p. 461 30. Chapter 23 Analytical techniques in identifying and purifying the proteins - p. 473 31. Index - p. 491
Lantibiotics as Alternative Therapeutics explores alternative therapeutics, lantibiotics and other novel drugs. This book provides concrete information to readers regarding lantibiotics and various types of antimicrobial peptides with their mode of actions in treating various multidrug resistant organisms. It explains various techniques that are involved in analyzing antimicrobial peptides and their mode of actions. The development of antibiotic resistance has now reached a point of crisis where innovative methods and application of novel compounds and methods are required to prevent the spread of drug resistant infections.
Novel compounds exhibit different modes of action to the currently used mechanism of therapeutics in order to combat against the resistant organisms. Lantibiotics hold considerable potential as a consequence of their unusual structure, unique mechanisms of action and their potency against multi-drug resistant bacteria. This book will be useful for pharmaceutical industry scientists and researchers in microbial and biomedical research as well as graduate and advanced students in microbiology, medical biotechnology, health, and pharmaceutical sciences.
1. Lantibiotics as Alternative Therapeutics - p. i 2. Cover - p. i 3. Title Page - p. iii 4. Copyright Page - p. iv 5. Table of Contents - p. iv 6. List of Contributors - p. xiii 7. Preface - p. xvii 8. Chapter 1 Quandary of antibiotics and multidrug resistance development: a molecular genetics-based dilemma - p. 1 9. Chapter 2 Antimicrobial peptides and their potent mechanism of action - p. 25 10. Chapter 3 Biosynthesis of lantibiotics - p. 43 11. Chapter 4 Development of recombinant lantibiotics and their potent uses - p. 65 12. Chapter 5 Mechanism of action of the lantibiotics on the multidrug-resistant organisms - p. 85 13. Chapter 6 Lantibiotics, its role in the meat and poultry industry - p. 119 14. Chapter 7 Application of lantibiotics in canned food preservation - p. 147 15. Chapter 8 Lantibiotics and its role in dairy product preservation - p. 169 16. Chapter 9 In vitro studies on a natural lantibiotic: paenibacillin - p. 191 17. Chapter 10 Lantibiotics in antifungal therapy: a futuristic approach - p. 205 18. Chapter 11 In silico studies of interaction of lantibiotics with virulent proteins - p. 221 19. Chapter 12 Insights at the atomistic resolution of lantibiotics using multiscale simulations - p. 241 20. Chapter 13 Immunogenicity studies on lantibiotics - p. 255 21. Chapter 14 Case studies: application of lantibiotics as novel drugs - p. 277 22. Chapter 15 Recent updates in understanding of molecular genetics of lantibiotics production - p. 301 23. Chapter 16 Methods for identification of the modes of action of lantibiotics - p. 319 24. Chapter 17 Computational modeling for exploring the therapeutic repertoire of lantibiotics - p. 337 25. Chapter 18 Combinations of nanobiomolecules as next-generation antimicrobial agents - p. 353 26. Chapter 19 Lantibiotics: the way forward for clinical trials and clinical approval process - p. 377 27. Chapter 20 Properties, classification and applications of lantibiotics from Gram-positive bacteria - p. 411 28. Chapter 21 Lantibiotics production—optimization and scale-up research: cutting edge and challenges - p. 427 29. Chapter 22 Production and optimization of lantibiotics - p. 461 30. Chapter 23 Analytical techniques in identifying and purifying the proteins - p. 473 31. Index - p. 491
