Liposomes in Drug Delivery: What, Where, How and When to Deliver is a concise, well-structured reference covering all the important issues related to the potential of this technology. Organized to provide practical information to researchers from any discipline with a particular therapeutic or bio-active substance to deliver, this book helps readers understand if liposomes can be of benefit for their particular need, what is the best type of liposome to use according to what needs to be delivered, where/when to deliver it, and how to design/prepare/characterize/investigate/optimize liposome properties for a particular application. The book is structured in Four parts. The first covers in a concise but in-depth way, what liposomes are, which are the liposome types, advantages/disadvantages, and what is their stability, characterization methods, in vitro stability, and in vivo fate after different administration methods (routes). The second part focuses on the different mechanisms for liposomal drug delivery. Methodologies/technologies for manipulation of liposome structure/properties in order to design liposomes for particular delivery applications. Specific roadmaps for liposome design are discussed, including components to incorporate in liposomes for specific types of encapsulated molecules or specific routes of administration. The third part covers liposome applications for drug delivery. It focuses on specific delivery considerations for particular diseases. Finally, the fourth part covers methods of liposome fabrication.
1. Chapter 1. Introduction to liposome assisted drug delivery - p. 1 2. Chapter 2. Basic concepts of liposomes: Components, structures, properties and classification - p. 19 3. Chapter 3. Liposome characterization methodologies (physical and chemical methods) - p. 49 4. Chapter 4. Morphological assessment of liposomes by microscopy - p. 71 5. Chapter 5. Liposome stability and integrity - p. 89 6. Chapter 6. In vivo fate of liposomes: Biodistribution and cell membrane interactions - p. 123 7. Chapter 7. Liposomes in controlled drug delivery: Controlling drug release kinetics and biodistribution/pharmacokinetics - p. 165 8. Chapter 8. Liposome surface modifications-engineering techniques - p. 193 9. Chapter 9. Activatable liposomes: Ultrasound-activated liposomes and lipid vesicles - p. 217 10. Chapter 10. Liposomes for drug delivery to the brain - p. 243 11. Chapter 11. Liposomes for drug delivery to cancer cells - p. 263 12. Chapter 12. Liposomes as vaccine delivery systems - p. 275 13. Chapter 13. Liposomes as DNA, mRNA and oligonucleotide delivery vectors - p. 303 14. Chapter 14. Liposomes for drug delivery by localized routes of administration - p. 329 15. Chapter 15. Liposomes for infectious diseases - p. 363 16. Chapter 16. Liposomes for drug delivery via biomaterials - p. 405 17. Chapter 17. Liposomes for delivery of substances for other (non-therapeutic) applications - p. 435 18. Chapter 18. Conventional methods for preparing liposomes of various types (MLVs, LUVs, SUVs): What, where, how and when - p. 461 19. Chapter 19. Size reduction, purification, sterilization and storage/packaging of liposomes - p. 489 20. Chapter 20. Methods for preparation of giant liposomes: Conventional methods; modified electro-techniques - p. 517 21. Chapter 21. Microfluidic methods for liposome formation - p. 539 22. Chapter 22. Supercritical fluid methods for liposome production and sterilization - p. 559 23. Chapter 23. Design of experiment approaches for liposome property optimization - p. 583 24. Chapter 24. Development of generic liposome products for drug delivery - p. 613 25. Chapter 25. Success stories, final remarks and directions of the field - p. 635 26. Index - p. 643
Liposomes in Drug Delivery: What, Where, How and When to Deliver is a concise, well-structured reference covering all the important issues related to the potential of this technology. Organized to provide practical information to researchers from any discipline with a particular therapeutic or bio-active substance to deliver, this book helps readers understand if liposomes can be of benefit for their particular need, what is the best type of liposome to use according to what needs to be delivered, where/when to deliver it, and how to design/prepare/characterize/investigate/optimize liposome properties for a particular application. The book is structured in Four parts. The first covers in a concise but in-depth way, what liposomes are, which are the liposome types, advantages/disadvantages, and what is their stability, characterization methods, in vitro stability, and in vivo fate after different administration methods (routes). The second part focuses on the different mechanisms for liposomal drug delivery. Methodologies/technologies for manipulation of liposome structure/properties in order to design liposomes for particular delivery applications. Specific roadmaps for liposome design are discussed, including components to incorporate in liposomes for specific types of encapsulated molecules or specific routes of administration. The third part covers liposome applications for drug delivery. It focuses on specific delivery considerations for particular diseases. Finally, the fourth part covers methods of liposome fabrication.
1. Chapter 1. Introduction to liposome assisted drug delivery - p. 1 2. Chapter 2. Basic concepts of liposomes: Components, structures, properties and classification - p. 19 3. Chapter 3. Liposome characterization methodologies (physical and chemical methods) - p. 49 4. Chapter 4. Morphological assessment of liposomes by microscopy - p. 71 5. Chapter 5. Liposome stability and integrity - p. 89 6. Chapter 6. In vivo fate of liposomes: Biodistribution and cell membrane interactions - p. 123 7. Chapter 7. Liposomes in controlled drug delivery: Controlling drug release kinetics and biodistribution/pharmacokinetics - p. 165 8. Chapter 8. Liposome surface modifications-engineering techniques - p. 193 9. Chapter 9. Activatable liposomes: Ultrasound-activated liposomes and lipid vesicles - p. 217 10. Chapter 10. Liposomes for drug delivery to the brain - p. 243 11. Chapter 11. Liposomes for drug delivery to cancer cells - p. 263 12. Chapter 12. Liposomes as vaccine delivery systems - p. 275 13. Chapter 13. Liposomes as DNA, mRNA and oligonucleotide delivery vectors - p. 303 14. Chapter 14. Liposomes for drug delivery by localized routes of administration - p. 329 15. Chapter 15. Liposomes for infectious diseases - p. 363 16. Chapter 16. Liposomes for drug delivery via biomaterials - p. 405 17. Chapter 17. Liposomes for delivery of substances for other (non-therapeutic) applications - p. 435 18. Chapter 18. Conventional methods for preparing liposomes of various types (MLVs, LUVs, SUVs): What, where, how and when - p. 461 19. Chapter 19. Size reduction, purification, sterilization and storage/packaging of liposomes - p. 489 20. Chapter 20. Methods for preparation of giant liposomes: Conventional methods; modified electro-techniques - p. 517 21. Chapter 21. Microfluidic methods for liposome formation - p. 539 22. Chapter 22. Supercritical fluid methods for liposome production and sterilization - p. 559 23. Chapter 23. Design of experiment approaches for liposome property optimization - p. 583 24. Chapter 24. Development of generic liposome products for drug delivery - p. 613 25. Chapter 25. Success stories, final remarks and directions of the field - p. 635 26. Index - p. 643
