Magnetic Nanoparticles in Nanomedicine provides readers with the fundamental theories and principles of magnetic materials, the synthesis and surface functionalization strategies of MNPs, and the standard techniques for characterizing physicochemical properties of MNPs. Other sections review MNP-based therapies such as magnetic hyperthermia therapy, drug/gene delivery, and magnetic neurostimulation and cover MNP-based in vitro and in vivo disease diagnosis, respectively, including techniques such as magnetoresistive (MR), nuclear magnetic resonance (NMR), magnetic particle spectroscopy (MPS) biosensing platforms, magnetic resonance imaging (MRI), and magnetic particle imaging (MPI). Final chapters address biocompatibility and safety issues in applying MNPs to in vivo biomedical applications, including coverage of the toxicity of MNPs to human tissues, the immune responses of the human body to these particles, as well as blood circulation time of MNPs.
1. Magnetic Nanoparticles in Nanomedicine - p. i 2. Cover - p. i 3. Title Page - p. iii 4. Copyright Page - p. iv 5. Contents - p. v 6. List of contributors - p. xv 7. Foreword - p. xix 8. Preface - p. xxi 9. Chapter 1 Basics of magnetic materials and magnetism - p. 3 10. Chapter 2 Micromagnetic simulation tools: OOMMF, Mumax3, and COMSOL Multiphysics - p. 37 11. Chapter 3 Physical methods for the synthesis of MNPs - p. 83 12. Chapter 4 Chemical and biological methods for the synthesis of magnetic nanoparticles - p. 115 13. Chapter 5 Surface chemical functionalization of magnetic nanoparticles - p. 135 14. Chapter 6 Characterization methods for magnetic nanoparticles - p. 155 15. Chapter 7 Self-regulating magnetic nanoparticles for hyperthermia therapy - p. 181 16. Chapter 8 Magnetic nanoparticles for drug/gene delivery - p. 207 17. Chapter 9 Magnetic nanoparticles for neurostimulation - p. 247 18. Chapter 10 Magnetoresistive (MR) biosensor - p. 289 19. Chapter 11 Magnetic particle spectroscopy (MPS) biosensor - p. 323 20. Chapter 12 Magnetic separation-assisted diagnosis - p. 351 21. Chapter 13 Magnetic nanoparticles in magnetic resonance imaging: principles and applications - p. 371 22. Chapter 14 Magnetic nanoparticles in magnetic particle imaging: principles and applications - p. 401 23. Chapter 15 Immunotoxicity and safety considerations - p. 461 24. Index - p. 499
Magnetic Nanoparticles in Nanomedicine provides readers with the fundamental theories and principles of magnetic materials, the synthesis and surface functionalization strategies of MNPs, and the standard techniques for characterizing physicochemical properties of MNPs. Other sections review MNP-based therapies such as magnetic hyperthermia therapy, drug/gene delivery, and magnetic neurostimulation and cover MNP-based in vitro and in vivo disease diagnosis, respectively, including techniques such as magnetoresistive (MR), nuclear magnetic resonance (NMR), magnetic particle spectroscopy (MPS) biosensing platforms, magnetic resonance imaging (MRI), and magnetic particle imaging (MPI). Final chapters address biocompatibility and safety issues in applying MNPs to in vivo biomedical applications, including coverage of the toxicity of MNPs to human tissues, the immune responses of the human body to these particles, as well as blood circulation time of MNPs.
1. Magnetic Nanoparticles in Nanomedicine - p. i 2. Cover - p. i 3. Title Page - p. iii 4. Copyright Page - p. iv 5. Contents - p. v 6. List of contributors - p. xv 7. Foreword - p. xix 8. Preface - p. xxi 9. Chapter 1 Basics of magnetic materials and magnetism - p. 3 10. Chapter 2 Micromagnetic simulation tools: OOMMF, Mumax3, and COMSOL Multiphysics - p. 37 11. Chapter 3 Physical methods for the synthesis of MNPs - p. 83 12. Chapter 4 Chemical and biological methods for the synthesis of magnetic nanoparticles - p. 115 13. Chapter 5 Surface chemical functionalization of magnetic nanoparticles - p. 135 14. Chapter 6 Characterization methods for magnetic nanoparticles - p. 155 15. Chapter 7 Self-regulating magnetic nanoparticles for hyperthermia therapy - p. 181 16. Chapter 8 Magnetic nanoparticles for drug/gene delivery - p. 207 17. Chapter 9 Magnetic nanoparticles for neurostimulation - p. 247 18. Chapter 10 Magnetoresistive (MR) biosensor - p. 289 19. Chapter 11 Magnetic particle spectroscopy (MPS) biosensor - p. 323 20. Chapter 12 Magnetic separation-assisted diagnosis - p. 351 21. Chapter 13 Magnetic nanoparticles in magnetic resonance imaging: principles and applications - p. 371 22. Chapter 14 Magnetic nanoparticles in magnetic particle imaging: principles and applications - p. 401 23. Chapter 15 Immunotoxicity and safety considerations - p. 461 24. Index - p. 499
