Materials for Bone Disorders is written by a cross-disciplinary team of research scientists, engineers, and clinicians and bridges the gap between materials science and bone disorders, providing integrated coverage of biomaterials and their applications. The bioceramics, biopolymers, composites, and metallic materials used in the treatment of bone disorders are introduced, as are their interactions with cells, biomolecules, and body tissues. The main types of bone disorder and disease are covered including osteoporosis, spinal injury, load bearing joint diseases, bone cancer, and forms of cranio-maxillofacial disorders.
Bone disorders are common across all ages. Various forms of bone disorders can change the lifestyle of otherwise normal and healthy people. With the development of novel materials, many forms of bone disorders are becoming manageable, allowing people to lead a fairly normal life. Specific consideration is given to areas where recent advances are enabling new treatments, such as the use of resorbable ceramics in bone tissue engineering and drug delivery, newer polymer-based implants in load-bearing contexts, and engineering biomaterials surfaces including modifying surface chemistry. Ethical and regulatory issues are also explored.
1. Chapter 1. Introduction to Biomaterials and Devices for Bone Disorders - p. 1 2. Chapter 2. Bone Biology and Effects of Pharmaceutical Intervention on Bone Quality - p. 29 3. Chapter 3. Bone Disorders - p. 83 4. Chapter 4. Implants for Joint Replacement of the Hip and Knee - p. 119 5. Abstract - p. 119 6. 4.1 Historical Perspective - p. 119 7. 4.2 Design and Material Issues, Clinical Outcome - p. 123 8. 4.3 Current Critical Issues - p. 136 9. 4.4 Future Trends and Next-Generation Devices - p. 177 10. 4.5 Conclusion - p. 179 11. References - p. 180 12. Chapter 5. Material and Mechanobiological Considerations for Bone Regeneration - p. 197 13. Abstract - p. 197 14. 5.1 Introduction - p. 197 15. 5.2 Physiology of Bone Regeneration - p. 200 16. 5.3 Mechanical Properties of Materials for Bone Regeneration - p. 205 17. 5.4 Cell-Level Mechanobiology of Bone Regeneration - p. 225 18. 5.5 Tissue-Level Mechanobiology of Bone Regeneration - p. 235 19. 5.6 Conclusions and Future Directions - p. 243 20. References - p. 246 21. Chapter 6. Ceramics in Bone Grafts and Coated Implants - p. 265 22. Chapter 7. Ceramic Coatings in Load-Bearing Articulating Joint Implants - p. 315 23. Chapter 8. Polymers and Composites for Orthopedic Applications - p. 349 24. Chapter 9. Surface Modifications and Surface Characterization of Biomaterials Used in Bone Healing - p. 405 25. Chapter 10. Predictive Methodologies for Design of Bone Tissue Engineering Scaffolds - p. 453 26. Chapter 11. Ethical Issues in Biomaterials Research - p. 493 27. Chapter 12. Research on Bone Disorders—From Ideas to Clinical Use Product—The Path to Commercialization - p. 505 28. Chapter 13. Current Challenges and Future Needs in Biomaterials and Devices for Bone Disorders - p. 517 29. Index - p. 527
Materials for Bone Disorders is written by a cross-disciplinary team of research scientists, engineers, and clinicians and bridges the gap between materials science and bone disorders, providing integrated coverage of biomaterials and their applications. The bioceramics, biopolymers, composites, and metallic materials used in the treatment of bone disorders are introduced, as are their interactions with cells, biomolecules, and body tissues. The main types of bone disorder and disease are covered including osteoporosis, spinal injury, load bearing joint diseases, bone cancer, and forms of cranio-maxillofacial disorders.
Bone disorders are common across all ages. Various forms of bone disorders can change the lifestyle of otherwise normal and healthy people. With the development of novel materials, many forms of bone disorders are becoming manageable, allowing people to lead a fairly normal life. Specific consideration is given to areas where recent advances are enabling new treatments, such as the use of resorbable ceramics in bone tissue engineering and drug delivery, newer polymer-based implants in load-bearing contexts, and engineering biomaterials surfaces including modifying surface chemistry. Ethical and regulatory issues are also explored.
1. Chapter 1. Introduction to Biomaterials and Devices for Bone Disorders - p. 1 2. Chapter 2. Bone Biology and Effects of Pharmaceutical Intervention on Bone Quality - p. 29 3. Chapter 3. Bone Disorders - p. 83 4. Chapter 4. Implants for Joint Replacement of the Hip and Knee - p. 119 5. Abstract - p. 119 6. 4.1 Historical Perspective - p. 119 7. 4.2 Design and Material Issues, Clinical Outcome - p. 123 8. 4.3 Current Critical Issues - p. 136 9. 4.4 Future Trends and Next-Generation Devices - p. 177 10. 4.5 Conclusion - p. 179 11. References - p. 180 12. Chapter 5. Material and Mechanobiological Considerations for Bone Regeneration - p. 197 13. Abstract - p. 197 14. 5.1 Introduction - p. 197 15. 5.2 Physiology of Bone Regeneration - p. 200 16. 5.3 Mechanical Properties of Materials for Bone Regeneration - p. 205 17. 5.4 Cell-Level Mechanobiology of Bone Regeneration - p. 225 18. 5.5 Tissue-Level Mechanobiology of Bone Regeneration - p. 235 19. 5.6 Conclusions and Future Directions - p. 243 20. References - p. 246 21. Chapter 6. Ceramics in Bone Grafts and Coated Implants - p. 265 22. Chapter 7. Ceramic Coatings in Load-Bearing Articulating Joint Implants - p. 315 23. Chapter 8. Polymers and Composites for Orthopedic Applications - p. 349 24. Chapter 9. Surface Modifications and Surface Characterization of Biomaterials Used in Bone Healing - p. 405 25. Chapter 10. Predictive Methodologies for Design of Bone Tissue Engineering Scaffolds - p. 453 26. Chapter 11. Ethical Issues in Biomaterials Research - p. 493 27. Chapter 12. Research on Bone Disorders—From Ideas to Clinical Use Product—The Path to Commercialization - p. 505 28. Chapter 13. Current Challenges and Future Needs in Biomaterials and Devices for Bone Disorders - p. 517 29. Index - p. 527
