Learn the what, how, and why of pathophysiology! With easy-to-read, in-depth descriptions of disease, disease etiology, and disease processes, McCance and Huether’s Pathophysiology: The Biologic Basis for Disease in Adults and Children, 9th Edition helps you understand the most important and most complex pathophysiology concepts. This updated text includes more than 1,300 full-color illustrations and photographs to make it easier to identify normal anatomy and physiology, as well as alterations of function. It’s the most comprehensive and authoritative pathophysiology text available!
New to this edition
Key Features
Author Information
By Julia Rogers, DNP, RN, CNS, FNP-BC, Assistant Professor College of Nursing Purdue University
1. Cover image - p. Cover 2. Title page - p. i 3. Table of Contents - p. xiii 4. Copyright - p. iv 5. Dedication - p. v 6. Contributors - p. vii 7. Preface - p. ix 8. Acknowledgments - p. xii 9. Part One: Central Concepts of Pathophysiology: Cells and Tissues - p. 1 10. Unit I: The Cell - p. 1a 11. 1. Cellular Biology - p. 1b 12. 2. Altered Cellular and Tissue Biology: Environmental Agents - p. 43 13. Chapter Outline - p. 43 14. Cellular Adaptation - p. 44 15. Cellular Injury - p. 47 16. Manifestations of Cellular Injury - p. 80 17. Cellular Death - p. 85 18. Aging and Altered Cellular and Tissue Biology - p. 91 19. Somatic Death - p. 95 20. Summary Review - p. 97 21. References - p. 100 22. 3. The Cellular Environment: Fluids and Electrolytes, Acids and Bases - p. 106 23. Unit II: Genes and Gene-Environment Interaction - p. 140 24. 4. Genes and Genetic Diseases - p. 140a 25. 5. Genes, Environment-Lifestyle, and Common Diseases - p. 167 26. 6. Epigenetics and Disease - p. 187 27. Unit III: Mechanisms of Self-Defense - p. 202 28. 7. Innate Immunity Inflammation and Wound Healing - p. 202a 29. 8. Adaptive Immunity - p. 231 30. 9. Alterations in Immunity - p. 255 31. 10. Infection - p. 281 32. 11. Stress and Disease - p. 310 33. Unit IV: Cellular Proliferation: Cancer - p. 331 34. 12. Cancer Biology - p. 331a 35. Outline - p. 331a 36. Cancer Terminology and Characteristics - p. 331a 37. The Biology of Cancer Cells - p. 334 38. Activating Invasion and Metastasis - p. 354 39. Clinical Manifestations of Cancer - p. 367 40. Diagnosis and Staging of Cancer - p. 371 41. Treatment of Cancer - p. 373 42. Targeted Disruption of Cancer - p. 376 43. Summary Review - p. 376 44. References - p. 381 45. 13. Cancer Epidemiology - p. 388 46. 14. Cancer in Children and Adolescents - p. 430 47. Part Two: Structure, Function, and Pathophysiologic Alterations: Organs and Systems - p. 441 48. Unit V: The Neurologic System - p. 441a 49. 15. Structure and Function of the Neurologic System - p. 441b 50. 16. Pain, Temperature Regulation, Sleep, and Sensory Function - p. 474 51. 17. Alterations in Cognitive Systems, Cerebral Hemodynamics, and Motor Function - p. 509 52. Chapter Outline - p. 509 53. Alterations in Cognitive Systems - p. 509 54. Alterations in Cerebral Hemodynamics - p. 534 55. Alterations in Neuromotor Function - p. 538 56. Chronic Diseases and Disorders Involving Motor Function - p. 547 57. Summary Review - p. 563 58. References - p. 565 59. 18. Alterations of the Brain, Spinal Cord, and Peripheral Nerves - p. 570 60. Chapter Outline - p. 570 61. Central Nervous System Disorders - p. 570 62. Infection and Inflammation of the Central Nervous System - p. 599 63. Peripheral Nervous System Disorders - p. 605 64. Tumors of the Central Nervous System - p. 606 65. Summary Review - p. 611 66. References - p. 613 67. 19. Neurobiology of Schizophrenia, Mood Disorders, Anxiety Disorders, Posttraumatic Stress Disorder, and Obsessive-Compulsive Disorder - p. 618 68. 20. Alterations of Neurologic Function in Children - p. 640 69. Unit VI: The Endocrine System - p. 662 70. 21. Mechanisms of Hormonal Regulation - p. 662a 71. 22. Alterations of Hormonal Regulation - p. 688 72. 23. Obesity, Starvation, and Anorexia of Aging - p. 723 73. Unit VII: The Reproductive Systems - p. 738 74. 24. Structure and Function of the Reproductive Systems - p. 738a 75. 25. Alterations of the Female Reproductive System - p. 767 76. Chapter Outline - p. 767 77. Abnormalities of the Female Reproductive Tract - p. 767 78. Alterations of Sexual Maturation - p. 768 79. Disorders of the Female Reproductive System - p. 770 80. Disorders of the Female Breast - p. 802 81. Summary Review - p. 814 82. References - p. 816 83. 26. Alterations of the Male Reproductive System - p. 822 84. Chapter Outline - p. 822 85. Alterations of Sexual Maturation - p. 823 86. Disorders of the Male Reproductive System - p. 825 87. Disorders of the Male Breast - p. 855 88. Summary Review - p. 856 89. References - p. 857 90. Online References - p. 864.e1 91. 27. Sexually Transmitted Infections - p. 865 92. Unit VIII: The Hematologic System - p. 892 93. 28. Structure and Function of the Hematologic System - p. 892a 94. 29. Alterations of Hematologic Function - p. 925 95. Chapter Outline - p. 925 96. Anemia - p. 925 97. Myeloproliferative Red Cell Disorders - p. 939 98. Alterations of Leukocyte Function - p. 942 99. Alterations of Lymphoid Function - p. 957 100. Alterations of Splenic Function - p. 966 101. Hemorrhagic Disorders and Alterations of Platelets and Coagulation - p. 967 102. Summary Review - p. 979 103. References - p. 983 104. 30. Alterations of Hematologic Function in Children - p. 987 105. Unit IX: The Cardiovascular and Lymphatic Systems - p. 1020 106. 31. Structure and Function of the Cardiovascular and Lymphatic Systems - p. 1020a 107. 32. Alterations of Cardiovascular Function - p. 1059 108. Chapter Outline - p. 1059 109. Diseases of the Veins - p. 1059 110. Diseases of the Arteries - p. 1061 111. Disorders of the Heart Wall - p. 1084 112. Manifestations of Heart Disease - p. 1096 113. Summary Review - p. 1102 114. References - p. 1105 115. 33. Alterations of Cardiovascular Function in Children - p. 1109 116. Unit X: The Pulmonary System - p. 1131 117. 34. Structure and Function of the Pulmonary System - p. 1131a 118. 35. Alterations of Pulmonary Function - p. 1153 119. 36. Alterations of Pulmonary Function in Children - p. 1191 120. Unit XI: The Renal and Urologic Systems - p. 1211 121. 37. Structure and Function of the Renal and Urologic Systems - p. 1211a 122. 38. Alterations of Renal and Urinary Tract Function - p. 1232 123. 39. Alterations of Renal and Urinary Tract Function in Children - p. 1270 124. Unit XII: The Digestive System - p. 1285 125. 40. Structure and Function of the Digestive System - p. 1285a 126. 41. Alterations of Digestive Function - p. 1318 127. Chapter Outline - p. 1318 128. Disorders of the Gastrointestinal Tract - p. 1318 129. Disorders of the accessory Organs of Digestion - p. 1342 130. Cancer of the Digestive System - p. 1357 131. Summary Review - p. 1366 132. References - p. 1370 133. 42. Alterations of Digestive Function in Children - p. 1375 134. Unit XIII: The Musculoskeletal System - p. 1399 135. 43. Structure and Function of the Musculoskeletal System - p. 1399a 136. 44. Alterations of Musculoskeletal Function - p. 1427 137. Chapter Outline - p. 1427 138. Musculoskeletal Injuries - p. 1427 139. Disorders of Bones - p. 1437 140. Disorders of Joints - p. 1452 141. Disorders of Skeletal Muscle - p. 1462 142. Muscle Tumors - p. 1470 143. Summary Review - p. 1471 144. References - p. 1473 145. 45. Alterations of Musculoskeletal Function in Children - p. 1476 146. Unit XIV: The Integumentary System - p. 1504 147. 46. Structure, Function, and Disorders of the Integument - p. 1504a 148. 47. Alterations of the Integument in Children - p. 1541 149. Unit XV: Multiple Interacting Systems - p. 1557 150. 48. Shock, Multiple Organ Dysfunction Syndrome, and Burns in Adults - p. 1557a 151. 49. Shock, Multiple Organ Dysfunction Syndrome, and Burns in Children - p. 1591 152. Glossary - p. 1622 153. Index - p. 1645 154. Common Laboratory Values - p. IBC1
Learn the what, how, and why of pathophysiology! With easy-to-read, in-depth descriptions of disease, disease etiology, and disease processes, McCance and Huether’s Pathophysiology: The Biologic Basis for Disease in Adults and Children, 9th Edition helps you understand the most important and most complex pathophysiology concepts. This updated text includes more than 1,300 full-color illustrations and photographs to make it easier to identify normal anatomy and physiology, as well as alterations of function. It’s the most comprehensive and authoritative pathophysiology text available!
New to this edition
Key Features
Author Information
By Julia Rogers, DNP, RN, CNS, FNP-BC, Assistant Professor College of Nursing Purdue University
1. Cover image - p. Cover 2. Title page - p. i 3. Table of Contents - p. xiii 4. Copyright - p. iv 5. Dedication - p. v 6. Contributors - p. vii 7. Preface - p. ix 8. Acknowledgments - p. xii 9. Part One: Central Concepts of Pathophysiology: Cells and Tissues - p. 1 10. Unit I: The Cell - p. 1a 11. 1. Cellular Biology - p. 1b 12. 2. Altered Cellular and Tissue Biology: Environmental Agents - p. 43 13. Chapter Outline - p. 43 14. Cellular Adaptation - p. 44 15. Cellular Injury - p. 47 16. Manifestations of Cellular Injury - p. 80 17. Cellular Death - p. 85 18. Aging and Altered Cellular and Tissue Biology - p. 91 19. Somatic Death - p. 95 20. Summary Review - p. 97 21. References - p. 100 22. 3. The Cellular Environment: Fluids and Electrolytes, Acids and Bases - p. 106 23. Unit II: Genes and Gene-Environment Interaction - p. 140 24. 4. Genes and Genetic Diseases - p. 140a 25. 5. Genes, Environment-Lifestyle, and Common Diseases - p. 167 26. 6. Epigenetics and Disease - p. 187 27. Unit III: Mechanisms of Self-Defense - p. 202 28. 7. Innate Immunity Inflammation and Wound Healing - p. 202a 29. 8. Adaptive Immunity - p. 231 30. 9. Alterations in Immunity - p. 255 31. 10. Infection - p. 281 32. 11. Stress and Disease - p. 310 33. Unit IV: Cellular Proliferation: Cancer - p. 331 34. 12. Cancer Biology - p. 331a 35. Outline - p. 331a 36. Cancer Terminology and Characteristics - p. 331a 37. The Biology of Cancer Cells - p. 334 38. Activating Invasion and Metastasis - p. 354 39. Clinical Manifestations of Cancer - p. 367 40. Diagnosis and Staging of Cancer - p. 371 41. Treatment of Cancer - p. 373 42. Targeted Disruption of Cancer - p. 376 43. Summary Review - p. 376 44. References - p. 381 45. 13. Cancer Epidemiology - p. 388 46. 14. Cancer in Children and Adolescents - p. 430 47. Part Two: Structure, Function, and Pathophysiologic Alterations: Organs and Systems - p. 441 48. Unit V: The Neurologic System - p. 441a 49. 15. Structure and Function of the Neurologic System - p. 441b 50. 16. Pain, Temperature Regulation, Sleep, and Sensory Function - p. 474 51. 17. Alterations in Cognitive Systems, Cerebral Hemodynamics, and Motor Function - p. 509 52. Chapter Outline - p. 509 53. Alterations in Cognitive Systems - p. 509 54. Alterations in Cerebral Hemodynamics - p. 534 55. Alterations in Neuromotor Function - p. 538 56. Chronic Diseases and Disorders Involving Motor Function - p. 547 57. Summary Review - p. 563 58. References - p. 565 59. 18. Alterations of the Brain, Spinal Cord, and Peripheral Nerves - p. 570 60. Chapter Outline - p. 570 61. Central Nervous System Disorders - p. 570 62. Infection and Inflammation of the Central Nervous System - p. 599 63. Peripheral Nervous System Disorders - p. 605 64. Tumors of the Central Nervous System - p. 606 65. Summary Review - p. 611 66. References - p. 613 67. 19. Neurobiology of Schizophrenia, Mood Disorders, Anxiety Disorders, Posttraumatic Stress Disorder, and Obsessive-Compulsive Disorder - p. 618 68. 20. Alterations of Neurologic Function in Children - p. 640 69. Unit VI: The Endocrine System - p. 662 70. 21. Mechanisms of Hormonal Regulation - p. 662a 71. 22. Alterations of Hormonal Regulation - p. 688 72. 23. Obesity, Starvation, and Anorexia of Aging - p. 723 73. Unit VII: The Reproductive Systems - p. 738 74. 24. Structure and Function of the Reproductive Systems - p. 738a 75. 25. Alterations of the Female Reproductive System - p. 767 76. Chapter Outline - p. 767 77. Abnormalities of the Female Reproductive Tract - p. 767 78. Alterations of Sexual Maturation - p. 768 79. Disorders of the Female Reproductive System - p. 770 80. Disorders of the Female Breast - p. 802 81. Summary Review - p. 814 82. References - p. 816 83. 26. Alterations of the Male Reproductive System - p. 822 84. Chapter Outline - p. 822 85. Alterations of Sexual Maturation - p. 823 86. Disorders of the Male Reproductive System - p. 825 87. Disorders of the Male Breast - p. 855 88. Summary Review - p. 856 89. References - p. 857 90. Online References - p. 864.e1 91. 27. Sexually Transmitted Infections - p. 865 92. Unit VIII: The Hematologic System - p. 892 93. 28. Structure and Function of the Hematologic System - p. 892a 94. 29. Alterations of Hematologic Function - p. 925 95. Chapter Outline - p. 925 96. Anemia - p. 925 97. Myeloproliferative Red Cell Disorders - p. 939 98. Alterations of Leukocyte Function - p. 942 99. Alterations of Lymphoid Function - p. 957 100. Alterations of Splenic Function - p. 966 101. Hemorrhagic Disorders and Alterations of Platelets and Coagulation - p. 967 102. Summary Review - p. 979 103. References - p. 983 104. 30. Alterations of Hematologic Function in Children - p. 987 105. Unit IX: The Cardiovascular and Lymphatic Systems - p. 1020 106. 31. Structure and Function of the Cardiovascular and Lymphatic Systems - p. 1020a 107. 32. Alterations of Cardiovascular Function - p. 1059 108. Chapter Outline - p. 1059 109. Diseases of the Veins - p. 1059 110. Diseases of the Arteries - p. 1061 111. Disorders of the Heart Wall - p. 1084 112. Manifestations of Heart Disease - p. 1096 113. Summary Review - p. 1102 114. References - p. 1105 115. 33. Alterations of Cardiovascular Function in Children - p. 1109 116. Unit X: The Pulmonary System - p. 1131 117. 34. Structure and Function of the Pulmonary System - p. 1131a 118. 35. Alterations of Pulmonary Function - p. 1153 119. 36. Alterations of Pulmonary Function in Children - p. 1191 120. Unit XI: The Renal and Urologic Systems - p. 1211 121. 37. Structure and Function of the Renal and Urologic Systems - p. 1211a 122. 38. Alterations of Renal and Urinary Tract Function - p. 1232 123. 39. Alterations of Renal and Urinary Tract Function in Children - p. 1270 124. Unit XII: The Digestive System - p. 1285 125. 40. Structure and Function of the Digestive System - p. 1285a 126. 41. Alterations of Digestive Function - p. 1318 127. Chapter Outline - p. 1318 128. Disorders of the Gastrointestinal Tract - p. 1318 129. Disorders of the accessory Organs of Digestion - p. 1342 130. Cancer of the Digestive System - p. 1357 131. Summary Review - p. 1366 132. References - p. 1370 133. 42. Alterations of Digestive Function in Children - p. 1375 134. Unit XIII: The Musculoskeletal System - p. 1399 135. 43. Structure and Function of the Musculoskeletal System - p. 1399a 136. 44. Alterations of Musculoskeletal Function - p. 1427 137. Chapter Outline - p. 1427 138. Musculoskeletal Injuries - p. 1427 139. Disorders of Bones - p. 1437 140. Disorders of Joints - p. 1452 141. Disorders of Skeletal Muscle - p. 1462 142. Muscle Tumors - p. 1470 143. Summary Review - p. 1471 144. References - p. 1473 145. 45. Alterations of Musculoskeletal Function in Children - p. 1476 146. Unit XIV: The Integumentary System - p. 1504 147. 46. Structure, Function, and Disorders of the Integument - p. 1504a 148. 47. Alterations of the Integument in Children - p. 1541 149. Unit XV: Multiple Interacting Systems - p. 1557 150. 48. Shock, Multiple Organ Dysfunction Syndrome, and Burns in Adults - p. 1557a 151. 49. Shock, Multiple Organ Dysfunction Syndrome, and Burns in Children - p. 1591 152. Glossary - p. 1622 153. Index - p. 1645 154. Common Laboratory Values - p. IBC1
