Mechanisms of Morphogenesis, Third Edition offers a bottom-up discussion of mechanisms of cell and tissue morphogenesis in a diverse array of organisms, including prokaryotes, animals, plants and fungi. Across foundational, applied and methods-based chapters, this book examines molecular nano-machines cooperation, generate cell shape, direct cell migration, and shape, form and rates of growth of various tissues in the body. Each topic is illustrated with experimental data from real systems, with particular reference to gaps in current knowledge and likely future developments, along with strategies to apply basic morphogenesis science across ever evolving applications.
Newly added chapters feature case-study-driven discussions of morphogenesis in natural embryos and organoids, and illustrate how pathological morphogenesis can generate variants of body form. This edition has also been updated with analysis of large-scale and scale-invariant mechanisms, for example, morphogenesis by differential growth in mechanically connected tissues.
1. Chapter 1 : INTRODUCTION—THE AIMS AND STRUCTURE OF THIS BOOK - p. Page x 2. Chapter 2 : KEY PRINCIPLES OF MORPHOGENESIS - p. Page 6 3. Chapter 3 : The Power and Limitations of Macro-Molecular Self-Assembly - p. Page 17 4. Chapter 4 : Morphogenesis of Individual Cells: A Brief Overview - p. Page 32 5. Chapter 5 : Animal Cell Shape: The Importance of the Cytoskeleton - p. Page 44 6. Chapter 6 : Cellular Morphogenesis in Plants - p. Page 68 7. Chapter 7 : Cell Migration in Development: A Brief Overview - p. Page 85 8. Chapter 8 : The Nano-Machinery of Locomotion - p. Page 97 9. Chapter 9 : Guidance by Chemotaxis - p. Page 113 10. Chapter 10 : Guidance by Galvanotaxis - p. Page 135 11. Chapter 11 : Guidance by Contact - p. Page 150 12. Chapter 12 : Waypoint Navigation in the Embryo - p. Page 168 13. Chapter 13 : Cooperative Migration of Mesenchymal Cells - p. Page 188 14. Chapter 14 : Condensation of Cells - p. Page 201 15. Chapter 15 : The Epithelial State: A Brief Overview - p. Page 212 16. Chapter 16 : Neighbour Exchange and Convergent Extension - p. Page 227 17. Chapter 17 : Epithelial Morphogenesis: Closure of Holes - p. Page 243 18. Chapter 18 : Invagination and Evagination: The Making and Shaping of Folds and Tubes - p. Page 254 19. Chapter 19 : Epithelial Fusion - p. Page 277 20. Chapter 20 : Epithelial Branching - p. Page 295 21. Chapter 21 : Boundaries to Epithelial Movement - p. Page 318 22. Chapter 22 : Growth, Proliferation and Death – A Brief Overview - p. Page 331 23. Chapter 23 : Morphogenesis by Orientated Cell Division - p. Page 356 24. Chapter 24 : Morphogenesis by Elective Cell Death - p. Page 376 25. Chapter 25 : From Mechanisms to Morphology: A Brief Overview - p. Page 389 26. Chapter 26 : Case Studies From Natural Development - p. Page 404 27. Chapter 27 : Morphogenesis in Organoids - p. Page 420 28. Chapter 28 : Pathological Morphogenesis - p. Page 429 29. Chapter 29 : Modelling Morphogenesis: A Brief Overview - p. Page 442 30. Chapter 30 : Mechanical and Mathematical Models of Morphogenesis - p. Page 454 31. Chapter 31 : Modelling Using Living Cells: Environment Switching, Tissue Engineering, and Synthetic Morphology - p. Page 473 32. Chapter 32 : Conclusions and Perspectives - p. Page 487 33. Index - p. Page 506
Mechanisms of Morphogenesis, Third Edition offers a bottom-up discussion of mechanisms of cell and tissue morphogenesis in a diverse array of organisms, including prokaryotes, animals, plants and fungi. Across foundational, applied and methods-based chapters, this book examines molecular nano-machines cooperation, generate cell shape, direct cell migration, and shape, form and rates of growth of various tissues in the body. Each topic is illustrated with experimental data from real systems, with particular reference to gaps in current knowledge and likely future developments, along with strategies to apply basic morphogenesis science across ever evolving applications.
Newly added chapters feature case-study-driven discussions of morphogenesis in natural embryos and organoids, and illustrate how pathological morphogenesis can generate variants of body form. This edition has also been updated with analysis of large-scale and scale-invariant mechanisms, for example, morphogenesis by differential growth in mechanically connected tissues.
1. Chapter 1 : INTRODUCTION—THE AIMS AND STRUCTURE OF THIS BOOK - p. Page x 2. Chapter 2 : KEY PRINCIPLES OF MORPHOGENESIS - p. Page 6 3. Chapter 3 : The Power and Limitations of Macro-Molecular Self-Assembly - p. Page 17 4. Chapter 4 : Morphogenesis of Individual Cells: A Brief Overview - p. Page 32 5. Chapter 5 : Animal Cell Shape: The Importance of the Cytoskeleton - p. Page 44 6. Chapter 6 : Cellular Morphogenesis in Plants - p. Page 68 7. Chapter 7 : Cell Migration in Development: A Brief Overview - p. Page 85 8. Chapter 8 : The Nano-Machinery of Locomotion - p. Page 97 9. Chapter 9 : Guidance by Chemotaxis - p. Page 113 10. Chapter 10 : Guidance by Galvanotaxis - p. Page 135 11. Chapter 11 : Guidance by Contact - p. Page 150 12. Chapter 12 : Waypoint Navigation in the Embryo - p. Page 168 13. Chapter 13 : Cooperative Migration of Mesenchymal Cells - p. Page 188 14. Chapter 14 : Condensation of Cells - p. Page 201 15. Chapter 15 : The Epithelial State: A Brief Overview - p. Page 212 16. Chapter 16 : Neighbour Exchange and Convergent Extension - p. Page 227 17. Chapter 17 : Epithelial Morphogenesis: Closure of Holes - p. Page 243 18. Chapter 18 : Invagination and Evagination: The Making and Shaping of Folds and Tubes - p. Page 254 19. Chapter 19 : Epithelial Fusion - p. Page 277 20. Chapter 20 : Epithelial Branching - p. Page 295 21. Chapter 21 : Boundaries to Epithelial Movement - p. Page 318 22. Chapter 22 : Growth, Proliferation and Death – A Brief Overview - p. Page 331 23. Chapter 23 : Morphogenesis by Orientated Cell Division - p. Page 356 24. Chapter 24 : Morphogenesis by Elective Cell Death - p. Page 376 25. Chapter 25 : From Mechanisms to Morphology: A Brief Overview - p. Page 389 26. Chapter 26 : Case Studies From Natural Development - p. Page 404 27. Chapter 27 : Morphogenesis in Organoids - p. Page 420 28. Chapter 28 : Pathological Morphogenesis - p. Page 429 29. Chapter 29 : Modelling Morphogenesis: A Brief Overview - p. Page 442 30. Chapter 30 : Mechanical and Mathematical Models of Morphogenesis - p. Page 454 31. Chapter 31 : Modelling Using Living Cells: Environment Switching, Tissue Engineering, and Synthetic Morphology - p. Page 473 32. Chapter 32 : Conclusions and Perspectives - p. Page 487 33. Index - p. Page 506
