Written by carefully selected global experts, practicing physicians, and educators in the various sub-disciplines of biochemistry, Medical Biochemistry, 6th Edition, offers a unique combination of research and clinical practice tailored to today's integrated courses. Covering clinically relevant topics in greater detail than other texts, this outstanding resource provides a strong overview of traditional areas in medical biochemistry along with state-of-the-art coverage of today’s latest developments. You’ll learn basic science concepts alongside clinical cases that describe patients likely to be encountered in clinical training, as well as how to use laboratory tests to diagnose and monitor the most important conditions. Thorough yet accessible, this clinically focused text is useful from medical school to clinical practice.
Features a strong clinical orientation, emphasizing the relevance of biochemistry to the daily practice of medicine.
Highlights the latest developments in regulatory and molecular biology, signal transduction, age-related chronic disease, epigenetics, and bioinformatics and the “-omics, as well as important global medical issues such as diabetes mellitus, obesity and malnutrition, cancer and atherosclerotic cardiovascular disease, and nutrition and exercise.
Emphasizes clinical evaluation, maintenance of good health, and disease prevention, as well as translational medicine and the diagnosis and treatment of disease.
Contains organ-focused chapters addressing the biochemistry of the bone, kidney, liver, lungs and muscle; and system-focused chapters on the biochemistry of the immune and endocrine systems, neurochemistry and neurotransmission, and cancer.
Includes clear, colorful icons and illustrations that help you easily navigate the text and understand the material.
Provides online features such as challenging “Active Learning questions for independent study, relevant websites that reinforce or supplement chapter content, 150+ multiple-choice and USMLE-style questions, a quick-reference glossary, additional images and case studies, references to current literature, and more.
1. Section 1: Introduction - p. xv 2. Chapter 1: Biochemistry and Clinical Medicine: Introduction and Overview - p. xv 3. Section 2: Molecules and Cells - p. 7 4. Chapter 2: Amino Acids and Proteins - p. 7 5. Chapter 3: Carbohydrates and Lipids - p. 24 6. Chapter 4: Membranes and Transport - p. 35 7. Section 3: Metabolism - p. 47 8. Chapter 5: Oxygen Transport - p. 47 9. Chapter 6: Catalytic Proteins - Enzymes - p. 63 10. Chapter 7: Vitamins and Minerals - p. 77 11. Chapter 8: Bioenergetics and Oxidative Metabolism - p. 94 12. Chapter 9: Glycolysis and the Pentose Phosphate Pathway - p. 113 13. Chapter 10: The Tricarboxylic Acid Cycle - p. 127 14. Chapter 11: Fatty Acid and Triglyceride Catabolism - p. 140 15. Chapter 12: Biosynthesis and Storage of Carbohydrate - p. 151 16. Chapter 13: Biosynthesis and Storage of Fatty Acids - p. 169 17. Chapter 14: Biosynthesis of Cholesterol and Steroids - p. 180 18. Chapter 15: Biosynthesis and Degradation of Amino Acids - p. 195 19. Chapter 16: Biosynthesis and Degradation of Nucleotides - p. 212 20. Chapter 17: Complex Carbohydrates: Glycoproteins - p. 224 21. Chapter 18: Complex Lipids - p. 241 22. Chapter 19: The Extracellular Matrix - p. 253 23. Section 4: Molecular Basis of Inheritance - p. 267 24. Chapter 20: Deoxyribonucleic Acid - p. 267 25. Chapter 21: Ribonucleic Acid - p. 287 26. Chapter 22: Protein Synthesis and Turnover - p. 302 27. Chapter 23: Regulation of Gene Expression: Basic Mechanisms - p. 315 28. Chapter 24: Genomics, Proteomics, and Metabolomics - p. 332 29. Section 5: Signalling and Growth - p. 357 30. Chapter 25: Membrane Receptors and Signal Transduction - p. 357 31. Chapter 26: Neurotransmitters - p. 373 32. Chapter 27: Biochemical Endocrinology - p. 388 33. Chapter 28: Cellular Homeostasis: Cell Growth and Cancer - p. 421 34. Chapter 29: Aging - p. 440 35. Section 6: Fuels Nutrients and Minerals - p. 454 36. Chapter 30: Digestion and Absorption of Nutrients: The Gastrointestinal Tract - p. 454 37. Chapter 31: Glucose Homeostasis and Fuel Metabolism: Diabetes Mellitus - p. 469 38. Chapter 32: Nutrients and Diets - p. 497 39. Chapter 33: Lipoprotein Metabolism and Atherogenesis - p. 516 40. Section 7: Specialized Tissues and Their Function - p. 538 41. Chapter 34: Role of the Liver in Metabolism - p. 538 42. Chapter 35: Water and Electrolytes Homeostasis - p. 553 43. Chapter 36: The Lung and the Regulation of Hydrogen Ion Concentration (Acid–Base Balance) - p. 571 44. Chapter 37: Muscle: Energy Metabolism, Contraction, and Exercise - p. 583 45. Chapter 38: Bone Metabolism and Calcium Homeostasis - p. 598 46. Chapter 39: Neurochemistry - p. 612 47. Section 8: Blood and Immunity. Clinical Biochemistry - p. 624 48. Chapter 40: Blood and Plasma Proteins - p. 624 49. Chapter 41: Hemostasis and Thrombosis - p. 634 50. Chapter 42: Oxidative Stress and Inflammation - p. 649 51. Chapter 43: The Immune Response: Innate and Adaptive Immunity - p. 661 52. Selected Clinical Laboratory Reference Ranges - p. 681 53. More Advanced Clinical Cases - p. 691 54. Baynes & Dominiczak: Medical Biochemistry 6E - p. e.5 55. MCQ Answers - p. e.74 56. Multiple Choice Questions - p. e.75 57. Patient-Oriented Problems (POPs) - p. e.99 58. Patient-Oriented Problem Answers - p. e.106 59. Short Answer Questions (SAQs) - p. e.110 60. Short Answers - p. e.115 61. Index - p. e.125
Written by carefully selected global experts, practicing physicians, and educators in the various sub-disciplines of biochemistry, Medical Biochemistry, 6th Edition, offers a unique combination of research and clinical practice tailored to today's integrated courses. Covering clinically relevant topics in greater detail than other texts, this outstanding resource provides a strong overview of traditional areas in medical biochemistry along with state-of-the-art coverage of today’s latest developments. You’ll learn basic science concepts alongside clinical cases that describe patients likely to be encountered in clinical training, as well as how to use laboratory tests to diagnose and monitor the most important conditions. Thorough yet accessible, this clinically focused text is useful from medical school to clinical practice.
Features a strong clinical orientation, emphasizing the relevance of biochemistry to the daily practice of medicine.
Highlights the latest developments in regulatory and molecular biology, signal transduction, age-related chronic disease, epigenetics, and bioinformatics and the “-omics, as well as important global medical issues such as diabetes mellitus, obesity and malnutrition, cancer and atherosclerotic cardiovascular disease, and nutrition and exercise.
Emphasizes clinical evaluation, maintenance of good health, and disease prevention, as well as translational medicine and the diagnosis and treatment of disease.
Contains organ-focused chapters addressing the biochemistry of the bone, kidney, liver, lungs and muscle; and system-focused chapters on the biochemistry of the immune and endocrine systems, neurochemistry and neurotransmission, and cancer.
Includes clear, colorful icons and illustrations that help you easily navigate the text and understand the material.
Provides online features such as challenging “Active Learning questions for independent study, relevant websites that reinforce or supplement chapter content, 150+ multiple-choice and USMLE-style questions, a quick-reference glossary, additional images and case studies, references to current literature, and more.
1. Section 1: Introduction - p. xv 2. Chapter 1: Biochemistry and Clinical Medicine: Introduction and Overview - p. xv 3. Section 2: Molecules and Cells - p. 7 4. Chapter 2: Amino Acids and Proteins - p. 7 5. Chapter 3: Carbohydrates and Lipids - p. 24 6. Chapter 4: Membranes and Transport - p. 35 7. Section 3: Metabolism - p. 47 8. Chapter 5: Oxygen Transport - p. 47 9. Chapter 6: Catalytic Proteins - Enzymes - p. 63 10. Chapter 7: Vitamins and Minerals - p. 77 11. Chapter 8: Bioenergetics and Oxidative Metabolism - p. 94 12. Chapter 9: Glycolysis and the Pentose Phosphate Pathway - p. 113 13. Chapter 10: The Tricarboxylic Acid Cycle - p. 127 14. Chapter 11: Fatty Acid and Triglyceride Catabolism - p. 140 15. Chapter 12: Biosynthesis and Storage of Carbohydrate - p. 151 16. Chapter 13: Biosynthesis and Storage of Fatty Acids - p. 169 17. Chapter 14: Biosynthesis of Cholesterol and Steroids - p. 180 18. Chapter 15: Biosynthesis and Degradation of Amino Acids - p. 195 19. Chapter 16: Biosynthesis and Degradation of Nucleotides - p. 212 20. Chapter 17: Complex Carbohydrates: Glycoproteins - p. 224 21. Chapter 18: Complex Lipids - p. 241 22. Chapter 19: The Extracellular Matrix - p. 253 23. Section 4: Molecular Basis of Inheritance - p. 267 24. Chapter 20: Deoxyribonucleic Acid - p. 267 25. Chapter 21: Ribonucleic Acid - p. 287 26. Chapter 22: Protein Synthesis and Turnover - p. 302 27. Chapter 23: Regulation of Gene Expression: Basic Mechanisms - p. 315 28. Chapter 24: Genomics, Proteomics, and Metabolomics - p. 332 29. Section 5: Signalling and Growth - p. 357 30. Chapter 25: Membrane Receptors and Signal Transduction - p. 357 31. Chapter 26: Neurotransmitters - p. 373 32. Chapter 27: Biochemical Endocrinology - p. 388 33. Chapter 28: Cellular Homeostasis: Cell Growth and Cancer - p. 421 34. Chapter 29: Aging - p. 440 35. Section 6: Fuels Nutrients and Minerals - p. 454 36. Chapter 30: Digestion and Absorption of Nutrients: The Gastrointestinal Tract - p. 454 37. Chapter 31: Glucose Homeostasis and Fuel Metabolism: Diabetes Mellitus - p. 469 38. Chapter 32: Nutrients and Diets - p. 497 39. Chapter 33: Lipoprotein Metabolism and Atherogenesis - p. 516 40. Section 7: Specialized Tissues and Their Function - p. 538 41. Chapter 34: Role of the Liver in Metabolism - p. 538 42. Chapter 35: Water and Electrolytes Homeostasis - p. 553 43. Chapter 36: The Lung and the Regulation of Hydrogen Ion Concentration (Acid–Base Balance) - p. 571 44. Chapter 37: Muscle: Energy Metabolism, Contraction, and Exercise - p. 583 45. Chapter 38: Bone Metabolism and Calcium Homeostasis - p. 598 46. Chapter 39: Neurochemistry - p. 612 47. Section 8: Blood and Immunity. Clinical Biochemistry - p. 624 48. Chapter 40: Blood and Plasma Proteins - p. 624 49. Chapter 41: Hemostasis and Thrombosis - p. 634 50. Chapter 42: Oxidative Stress and Inflammation - p. 649 51. Chapter 43: The Immune Response: Innate and Adaptive Immunity - p. 661 52. Selected Clinical Laboratory Reference Ranges - p. 681 53. More Advanced Clinical Cases - p. 691 54. Baynes & Dominiczak: Medical Biochemistry 6E - p. e.5 55. MCQ Answers - p. e.74 56. Multiple Choice Questions - p. e.75 57. Patient-Oriented Problems (POPs) - p. e.99 58. Patient-Oriented Problem Answers - p. e.106 59. Short Answer Questions (SAQs) - p. e.110 60. Short Answers - p. e.115 61. Index - p. e.125
