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1. Cover Image - p. i 2. Dedication - p. ii 3. Title Page - p. iii 4. Copyright - p. iv 5. Table of Contents - p. v 6. Preface - p. vii 7. Drug Dosage and Nomenclature - p. viii 8. Section 1 General Principles - p. viii 9. Chapter 1 Principles of Pharmacology and Mechanisms of Drug Action - p. 1 10. Chapter 2 Pharmacokinetics - p. 32 11. Chapter 3 Drug Discovery, Safety and Efficacy - p. 62 12. Chapter 4 Neurotransmission and the Peripheral Autonomic Nervous System - p. 71 13. Section 2 The Cardiovascular System - p. 88 14. Chapter 5 Ischaemic Heart Disease - p. 89 15. Chapter 6 Systemic and Pulmonary Hypertension - p. 108 16. Chapter 7 Heart Failure and Shock - p. 128 17. Chapter 8 Cardiac Arrhythmias - p. 142 18. Chapter 9 Cerebrovascular Disease and Dementia - p. 160 19. Chapter 10 Peripheral Artery Disease - p. 169 20. Chapter 11 Haemostasis - p. 175 21. Section 3 The Respiratory System - p. 191 22. Chapter 12 Asthma and Chronic Obstructive Pulmonary Disease - p. 192 23. Chapter 13 Respiratory Disorders: Cough, Respiratory Stimulants, Cystic Fibrosis, Idiopathic Pulmonary Fibrosis and Neonatal Respiratory Distress Syndrome - p. 211 24. Section 4 The Renal System - p. 217 25. Chapter 14 Diuretics - p. 218 26. Chapter 15 Disorders of Micturition - p. 229 27. Chapter 16 Erectile Dysfunction - p. 236 28. Section 5 The Nervous System - p. 241 29. Chapter 17 General Anaesthetics - p. 242 30. Chapter 18 Local Anaesthetics - p. 252 31. Chapter 19 Opioid Analgesics and the Management of Pain - p. 258 32. Chapter 20 Anxiety, Obsessive-Compulsive Disorder and Insomnia - p. 273 33. Chapter 21 Schizophrenia and Bipolar Disorder - p. 281 34. Chapter 22 Depression, Attention Deficit Hyperactivity Disorder and Narcolepsy - p. 292 35. Chapter 23 Seizures and Epilepsy - p. 308 36. Chapter 24 Extrapyramidal Movement Disorders and Spasticity - p. 323 37. Chapter 25 Other Neurological Disorders: Multiple Sclerosis, Motor Neuron Disease and Guillain–Barré Syndrome - p. 336 38. Chapter 26 Migraine and Other Headaches - p. 342 39. Section 6 The Musculoskeletal System - p. 349 40. Chapter 27 The Neuromuscular Junction and Neuromuscular Blockade - p. 350 41. Chapter 28 Myasthenia Gravis - p. 357 42. Chapter 29 Nonsteroidal Antiinflammatory Drugs - p. 361 43. Chapter 30 Rheumatoid Arthritis, Other Inflammatory Arthritides and Osteoarthritis - p. 371 44. Chapter 31 Hyperuricaemia, Gout and Pseudogout - p. 383 45. Section 7 The Gastrointestinal System - p. 388 46. Chapter 32 Nausea and Vomiting - p. 389 47. Chapter 33 Dyspepsia, Peptic Ulcer Disease and Gastrooesophageal Reflux Disease - p. 397 48. Chapter 34 Inflammatory Bowel Disease - p. 408 49. Chapter 35 Constipation, Diarrhoea and Irritable Bowel Syndrome - p. 415 50. Chapter 36 Liver Disease - p. 423 51. Chapter 37 Obesity - p. 432 52. Section 8 The Immune System - p. 436 53. Chapter 38 The Immune Response and Immunosuppressant Drugs - p. 437 54. Chapter 39 Antihistamines and Allergic Disease - p. 450 55. Section 9 The Endocrine System and Metabolism - p. 456 56. Chapter 40 Diabetes Mellitus - p. 457 57. Chapter 41 The Thyroid and Control of Metabolic Rate - p. 473 58. Chapter 42 Calcium Metabolism and Metabolic Bone Disease - p. 480 59. Chapter 43 Pituitary and Hypothalamic Hormones - p. 491 60. Chapter 44 Corticosteroids (Glucocorticoids and Mineralocorticoids) - p. 503 61. Chapter 45 Female Reproduction - p. 512 62. Chapter 46 Androgens, Antiandrogens and Anabolic Steroids - p. 530 63. Chapter 47 Anaemia and Haematopoietic Colony-Stimulating Factors - p. 535 64. Chapter 48 Lipid Disorders - p. 545 65. Section 10 The Skin and Eyes - p. 557 66. Chapter 49 Skin Disorders - p. 558 67. Chapter 50 The Eye - p. 567 68. Section 11 Antimicrobial Therapy - p. 577 69. Chapter 51 Drugs for Infections - p. 578 70. Section 12 Cancer - p. 629 71. Chapter 52 Drugs for Cancer - p. 630 72. Section 13 General Features: Toxicity and Prescribing - p. 660 73. Chapter 53 Drug Toxicity and Overdose - p. 661 74. Chapter 54 Substance Abuse and Dependence - p. 677 75. Chapter 55 Prescribing, Adherence and Information About Medicines - p. 693 76. Chapter 56 Drug Therapy in Special Situations - p. 700 77. Index - p. 712
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1. Cover Image - p. i 2. Dedication - p. ii 3. Title Page - p. iii 4. Copyright - p. iv 5. Table of Contents - p. v 6. Preface - p. vii 7. Drug Dosage and Nomenclature - p. viii 8. Section 1 General Principles - p. viii 9. Chapter 1 Principles of Pharmacology and Mechanisms of Drug Action - p. 1 10. Chapter 2 Pharmacokinetics - p. 32 11. Chapter 3 Drug Discovery, Safety and Efficacy - p. 62 12. Chapter 4 Neurotransmission and the Peripheral Autonomic Nervous System - p. 71 13. Section 2 The Cardiovascular System - p. 88 14. Chapter 5 Ischaemic Heart Disease - p. 89 15. Chapter 6 Systemic and Pulmonary Hypertension - p. 108 16. Chapter 7 Heart Failure and Shock - p. 128 17. Chapter 8 Cardiac Arrhythmias - p. 142 18. Chapter 9 Cerebrovascular Disease and Dementia - p. 160 19. Chapter 10 Peripheral Artery Disease - p. 169 20. Chapter 11 Haemostasis - p. 175 21. Section 3 The Respiratory System - p. 191 22. Chapter 12 Asthma and Chronic Obstructive Pulmonary Disease - p. 192 23. Chapter 13 Respiratory Disorders: Cough, Respiratory Stimulants, Cystic Fibrosis, Idiopathic Pulmonary Fibrosis and Neonatal Respiratory Distress Syndrome - p. 211 24. Section 4 The Renal System - p. 217 25. Chapter 14 Diuretics - p. 218 26. Chapter 15 Disorders of Micturition - p. 229 27. Chapter 16 Erectile Dysfunction - p. 236 28. Section 5 The Nervous System - p. 241 29. Chapter 17 General Anaesthetics - p. 242 30. Chapter 18 Local Anaesthetics - p. 252 31. Chapter 19 Opioid Analgesics and the Management of Pain - p. 258 32. Chapter 20 Anxiety, Obsessive-Compulsive Disorder and Insomnia - p. 273 33. Chapter 21 Schizophrenia and Bipolar Disorder - p. 281 34. Chapter 22 Depression, Attention Deficit Hyperactivity Disorder and Narcolepsy - p. 292 35. Chapter 23 Seizures and Epilepsy - p. 308 36. Chapter 24 Extrapyramidal Movement Disorders and Spasticity - p. 323 37. Chapter 25 Other Neurological Disorders: Multiple Sclerosis, Motor Neuron Disease and Guillain–Barré Syndrome - p. 336 38. Chapter 26 Migraine and Other Headaches - p. 342 39. Section 6 The Musculoskeletal System - p. 349 40. Chapter 27 The Neuromuscular Junction and Neuromuscular Blockade - p. 350 41. Chapter 28 Myasthenia Gravis - p. 357 42. Chapter 29 Nonsteroidal Antiinflammatory Drugs - p. 361 43. Chapter 30 Rheumatoid Arthritis, Other Inflammatory Arthritides and Osteoarthritis - p. 371 44. Chapter 31 Hyperuricaemia, Gout and Pseudogout - p. 383 45. Section 7 The Gastrointestinal System - p. 388 46. Chapter 32 Nausea and Vomiting - p. 389 47. Chapter 33 Dyspepsia, Peptic Ulcer Disease and Gastrooesophageal Reflux Disease - p. 397 48. Chapter 34 Inflammatory Bowel Disease - p. 408 49. Chapter 35 Constipation, Diarrhoea and Irritable Bowel Syndrome - p. 415 50. Chapter 36 Liver Disease - p. 423 51. Chapter 37 Obesity - p. 432 52. Section 8 The Immune System - p. 436 53. Chapter 38 The Immune Response and Immunosuppressant Drugs - p. 437 54. Chapter 39 Antihistamines and Allergic Disease - p. 450 55. Section 9 The Endocrine System and Metabolism - p. 456 56. Chapter 40 Diabetes Mellitus - p. 457 57. Chapter 41 The Thyroid and Control of Metabolic Rate - p. 473 58. Chapter 42 Calcium Metabolism and Metabolic Bone Disease - p. 480 59. Chapter 43 Pituitary and Hypothalamic Hormones - p. 491 60. Chapter 44 Corticosteroids (Glucocorticoids and Mineralocorticoids) - p. 503 61. Chapter 45 Female Reproduction - p. 512 62. Chapter 46 Androgens, Antiandrogens and Anabolic Steroids - p. 530 63. Chapter 47 Anaemia and Haematopoietic Colony-Stimulating Factors - p. 535 64. Chapter 48 Lipid Disorders - p. 545 65. Section 10 The Skin and Eyes - p. 557 66. Chapter 49 Skin Disorders - p. 558 67. Chapter 50 The Eye - p. 567 68. Section 11 Antimicrobial Therapy - p. 577 69. Chapter 51 Drugs for Infections - p. 578 70. Section 12 Cancer - p. 629 71. Chapter 52 Drugs for Cancer - p. 630 72. Section 13 General Features: Toxicity and Prescribing - p. 660 73. Chapter 53 Drug Toxicity and Overdose - p. 661 74. Chapter 54 Substance Abuse and Dependence - p. 677 75. Chapter 55 Prescribing, Adherence and Information About Medicines - p. 693 76. Chapter 56 Drug Therapy in Special Situations - p. 700 77. Index - p. 712
