Medical Pharmacology & Therapeutics, now in its fifth edition, offers medical students all they need to know to become safe and effective prescribers. It forms a complete, integrated resource for basic pharmaceutical science, pathophysiology, clinical pharmacology, and therapeutics.
The fifth edition has been extensively revised and updated throughout. Key features include:
1. Instructions for online access - p. 729 2. Cover image - p. iii 3. Title Page - p. iii 4. Table of Contents - p. iii 5. Dedication - p. ii 6. Copyright - p. iv 7. Preface - p. vii 8. Drug dosage and nomenclature - p. ix 9. Section 1 General Principles - p. ix 10. 1 Principles of pharmacology and mechanisms of drug action - p. 3 11. 2 Pharmacokinetics - p. 33 12. 3 Drug discovery, safety and efficacy - p. 63 13. 4 Neurotransmission and the peripheral autonomic nervous system - p. 73 14. Section 2 The Cardiovascular System - p. 90 15. 5 Ischaemic heart disease - p. 93 16. 6 Systemic and pulmonary hypertension - p. 111 17. 7 Heart failure - p. 131 18. 8 Cardiac arrhythmias - p. 143 19. 9 Cerebrovascular disease and dementia - p. 161 20. 10 Peripheral vascular disease - p. 169 21. 11 Haemostasis - p. 175 22. Section 3 The Respiratory System - p. 188 23. 12 Asthma and chronic obstructive pulmonary disease - p. 193 24. 13 Respiratory disorders - p. 211 25. Section 4 The Renal System - p. 215 26. 14 Diuretics - p. 219 27. 15 Disorders of micturition - p. 231 28. 16 Erectile dysfunction - p. 239 29. Section 5 The Nervous System - p. 243 30. 17 General anaesthetics - p. 247 31. 18 Local anaesthetics - p. 257 32. 19 Opioid analgesics and the management of pain - p. 263 33. 20 Anxiety, obsessive-compulsive disorder and insomnia - p. 279 34. 21 Schizophrenia and bipolar disorder - p. 287 35. 22 Depression, attention deficit hyperactivity disorder and narcolepsy - p. 297 36. 23 Epilepsy - p. 311 37. 24 Extrapyramidal movement disorders and spasticity - p. 325 38. 25 Other neurological disorders - p. 337 39. 26 Migraine and other headaches - p. 341 40. Section 6 The Musculoskeletal System - p. 346 41. 27 The neuromuscular junction and neuromuscular blockade - p. 351 42. 28 Myasthenia gravis - p. 359 43. 29 Nonsteroidal antiinflammatory drugs - p. 363 44. 30 Rheumatoid arthritis, other inflammatory arthritides and osteoarthritis - p. 373 45. 31 Hyperuricaemia and gout - p. 385 46. Section 7 The Gastrointestinal System - p. 389 47. 32 Nausea and vomiting - p. 393 48. 33 Dyspepsia and peptic ulcer disease - p. 401 49. 34 Inflammatory bowel disease - p. 411 50. 35 Constipation, diarrhoea and irritable bowel syndrome - p. 417 51. 36 Liver disease - p. 425 52. 37 Obesity - p. 433 53. Section 8 The Immune System - p. 436 54. 38 The immune response and immunosuppressant drugs - p. 439 55. 39 Antihistamines and allergic disease - p. 451 56. Section 9 The Endocrine System and Metabolism - p. 456 57. 40 Diabetes mellitus - p. 459 58. 41 The thyroid and control of metabolic rate - p. 475 59. 42 Calcium metabolism and metabolic bone disease - p. 481 60. 43 Pituitary and hypothalamic hormones - p. 491 61. 44 Corticosteroids (glucocorticoids and mineralocorticoids) - p. 503 62. 45 Female reproduction - p. 513 63. 46 Androgens, antiandrogens and anabolic steroids - p. 531 64. 47 Anaemia and haematopoietic colony-stimulating factors - p. 537 65. 48 Lipid disorders - p. 547 66. Section 10 The Skin and Eyes - p. 556 67. 49 Skin disorders - p. 561 68. 50 The eye - p. 569 69. Section 11 Chemotherapy - p. 575 70. 51 Chemotherapy of infections - p. 581 71. Bacterial Infections - p. 581 72. Fungal Infections - p. 601 73. Viral Infections - p. 604 74. Protozoal Infections - p. 611 75. Helminthic Infections - p. 615 76. Self-Assessment - p. 629 77. Answers - p. 618 78. Further Reading - p. 620 79. 52 Chemotherapy of malignancy - p. 631 80. Section 12 General Features: Drug Toxicity and Prescribing - p. 649 81. 53 Drug toxicity and overdose - p. 659 82. 54 Substance abuse and dependence - p. 675 83. 55 Prescribing, adherence and information about medicines - p. 689 84. 56 Drug therapy in special situations - p. 695 85. Index - p. 707
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Medical Pharmacology & Therapeutics, now in its fifth edition, offers medical students all they need to know to become safe and effective prescribers. It forms a complete, integrated resource for basic pharmaceutical science, pathophysiology, clinical pharmacology, and therapeutics.
The fifth edition has been extensively revised and updated throughout. Key features include:
1. Instructions for online access - p. 729 2. Cover image - p. iii 3. Title Page - p. iii 4. Table of Contents - p. iii 5. Dedication - p. ii 6. Copyright - p. iv 7. Preface - p. vii 8. Drug dosage and nomenclature - p. ix 9. Section 1 General Principles - p. ix 10. 1 Principles of pharmacology and mechanisms of drug action - p. 3 11. 2 Pharmacokinetics - p. 33 12. 3 Drug discovery, safety and efficacy - p. 63 13. 4 Neurotransmission and the peripheral autonomic nervous system - p. 73 14. Section 2 The Cardiovascular System - p. 90 15. 5 Ischaemic heart disease - p. 93 16. 6 Systemic and pulmonary hypertension - p. 111 17. 7 Heart failure - p. 131 18. 8 Cardiac arrhythmias - p. 143 19. 9 Cerebrovascular disease and dementia - p. 161 20. 10 Peripheral vascular disease - p. 169 21. 11 Haemostasis - p. 175 22. Section 3 The Respiratory System - p. 188 23. 12 Asthma and chronic obstructive pulmonary disease - p. 193 24. 13 Respiratory disorders - p. 211 25. Section 4 The Renal System - p. 215 26. 14 Diuretics - p. 219 27. 15 Disorders of micturition - p. 231 28. 16 Erectile dysfunction - p. 239 29. Section 5 The Nervous System - p. 243 30. 17 General anaesthetics - p. 247 31. 18 Local anaesthetics - p. 257 32. 19 Opioid analgesics and the management of pain - p. 263 33. 20 Anxiety, obsessive-compulsive disorder and insomnia - p. 279 34. 21 Schizophrenia and bipolar disorder - p. 287 35. 22 Depression, attention deficit hyperactivity disorder and narcolepsy - p. 297 36. 23 Epilepsy - p. 311 37. 24 Extrapyramidal movement disorders and spasticity - p. 325 38. 25 Other neurological disorders - p. 337 39. 26 Migraine and other headaches - p. 341 40. Section 6 The Musculoskeletal System - p. 346 41. 27 The neuromuscular junction and neuromuscular blockade - p. 351 42. 28 Myasthenia gravis - p. 359 43. 29 Nonsteroidal antiinflammatory drugs - p. 363 44. 30 Rheumatoid arthritis, other inflammatory arthritides and osteoarthritis - p. 373 45. 31 Hyperuricaemia and gout - p. 385 46. Section 7 The Gastrointestinal System - p. 389 47. 32 Nausea and vomiting - p. 393 48. 33 Dyspepsia and peptic ulcer disease - p. 401 49. 34 Inflammatory bowel disease - p. 411 50. 35 Constipation, diarrhoea and irritable bowel syndrome - p. 417 51. 36 Liver disease - p. 425 52. 37 Obesity - p. 433 53. Section 8 The Immune System - p. 436 54. 38 The immune response and immunosuppressant drugs - p. 439 55. 39 Antihistamines and allergic disease - p. 451 56. Section 9 The Endocrine System and Metabolism - p. 456 57. 40 Diabetes mellitus - p. 459 58. 41 The thyroid and control of metabolic rate - p. 475 59. 42 Calcium metabolism and metabolic bone disease - p. 481 60. 43 Pituitary and hypothalamic hormones - p. 491 61. 44 Corticosteroids (glucocorticoids and mineralocorticoids) - p. 503 62. 45 Female reproduction - p. 513 63. 46 Androgens, antiandrogens and anabolic steroids - p. 531 64. 47 Anaemia and haematopoietic colony-stimulating factors - p. 537 65. 48 Lipid disorders - p. 547 66. Section 10 The Skin and Eyes - p. 556 67. 49 Skin disorders - p. 561 68. 50 The eye - p. 569 69. Section 11 Chemotherapy - p. 575 70. 51 Chemotherapy of infections - p. 581 71. Bacterial Infections - p. 581 72. Fungal Infections - p. 601 73. Viral Infections - p. 604 74. Protozoal Infections - p. 611 75. Helminthic Infections - p. 615 76. Self-Assessment - p. 629 77. Answers - p. 618 78. Further Reading - p. 620 79. 52 Chemotherapy of malignancy - p. 631 80. Section 12 General Features: Drug Toxicity and Prescribing - p. 649 81. 53 Drug toxicity and overdose - p. 659 82. 54 Substance abuse and dependence - p. 675 83. 55 Prescribing, adherence and information about medicines - p. 689 84. 56 Drug therapy in special situations - p. 695 85. Index - p. 707
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