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This issue of Sleep Medicine Clinics focuses on Medications and their Effects on Sleep and Wake, with topics including: Sleep-wake neurochemistry; Effect of sleep and circadian rhythm on pharmacokinetics and pharmacodynamics; Drugs used in insomnia and non restorative sleep; Drug-induced exessive sleepiness; Drug-induced insomnia; Drug-induced sleep disordered breathing and ventilatory impairment; Drug-induced parasomnias and movement disorders; Abuse and dependency on sleep and waking; Sleep-related drug therapy in special conditions: children; Sleep-related drug therapy in special conditions: pregnancy; Sleep-related drug therapy in special conditions: the elderly; Medicolegal and social consequences of sleep disorders; and Tapering sleep-related drug therapy.

1. Cover image - p. i 2. Title page - p. i 3. Table of Contents - p. i 4. Copyright - p. ii 5. CME Accreditation Page - p. iii 6. Forthcoming Issues - p. v 7. Contributors - p. vii 8. Preface - p. xv 9. Sleep-Wake Neurochemistry - p. 137 10. Drug-Induced Insomnia and Excessive Sleepiness - p. 147 11. Drug-Induced Sleep-Disordered Breathing and Ventilatory Impairment - p. 161 12. Prescription Drugs Used in Insomnia - p. 169 13. Drugs Used in Narcolepsy and Other Hypersomnias - p. 183 14. Drugs Used in Parasomnia - p. 191 15. Drug Therapy in Obstructive Sleep Apnea - p. 203 16. Pharmacologic and Nonpharmacologic Treatment of Restless Legs Syndrome - p. 219 17. Drugs Used in Circadian Sleep-Wake Rhythm Disturbances - p. 231 18. Pharmacologic Treatment of Sleep Disorders in Pregnancy - p. 243 19. Sleep-Related Drug Therapy in Special Conditions: Children - p. 251 20. Hypnotic Discontinuation in Chronic Insomnia - p. 263 21. Effects of Chronic Opioid Use on Sleep and Wake - p. 271

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This issue of Sleep Medicine Clinics focuses on Medications and their Effects on Sleep and Wake, with topics including: Sleep-wake neurochemistry; Effect of sleep and circadian rhythm on pharmacokinetics and pharmacodynamics; Drugs used in insomnia and non restorative sleep; Drug-induced exessive sleepiness; Drug-induced insomnia; Drug-induced sleep disordered breathing and ventilatory impairment; Drug-induced parasomnias and movement disorders; Abuse and dependency on sleep and waking; Sleep-related drug therapy in special conditions: children; Sleep-related drug therapy in special conditions: pregnancy; Sleep-related drug therapy in special conditions: the elderly; Medicolegal and social consequences of sleep disorders; and Tapering sleep-related drug therapy.

1. Cover image - p. i 2. Title page - p. i 3. Table of Contents - p. i 4. Copyright - p. ii 5. CME Accreditation Page - p. iii 6. Forthcoming Issues - p. v 7. Contributors - p. vii 8. Preface - p. xv 9. Sleep-Wake Neurochemistry - p. 137 10. Drug-Induced Insomnia and Excessive Sleepiness - p. 147 11. Drug-Induced Sleep-Disordered Breathing and Ventilatory Impairment - p. 161 12. Prescription Drugs Used in Insomnia - p. 169 13. Drugs Used in Narcolepsy and Other Hypersomnias - p. 183 14. Drugs Used in Parasomnia - p. 191 15. Drug Therapy in Obstructive Sleep Apnea - p. 203 16. Pharmacologic and Nonpharmacologic Treatment of Restless Legs Syndrome - p. 219 17. Drugs Used in Circadian Sleep-Wake Rhythm Disturbances - p. 231 18. Pharmacologic Treatment of Sleep Disorders in Pregnancy - p. 243 19. Sleep-Related Drug Therapy in Special Conditions: Children - p. 251 20. Hypnotic Discontinuation in Chronic Insomnia - p. 263 21. Effects of Chronic Opioid Use on Sleep and Wake - p. 271

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