Mesenchymal stromal/ stem cells (MSCs) represent a heterogeneous cell population with immunomodulating, tissue repairing, differentiating, migratory and angiogenic abilities, making them important tools for clinical and translational research. An understanding of the role of MSCs in modulating tumor growth provides a glimpse into their role in non-pathological tissue remodeling and potential regenerative tissue therapies.
Mesenchymal Stromal Cells as Tumor Stromal Modulators is a comprehensive source for the understanding of the role of MSCs as ubiquitous connective tissue cell components, which may have both direct and indirect effects on the tumor microenvironment and potential for regenerative therapeutics for various diseases. Using cancer as a model disease, this book explores the transformative role MSCs play in the recruitment of disease cells, cell repair and immunological defenses.
1. Introduction - p. 552 2. Clinical Application of Ex Vivo Expanded Mesenchymal Stem/Stromal Cells - p. 552 3. Risks of Ex Vivo Expansion of Mesenchymal Stem/Stromal Cells - p. 556 4. Risks Related to Immunosuppression and Infection From Mesenchymal Stem/Stromal Cells - p. 561 5. Risks Related to Hypoimmunogenic Properties of Mesenchymal Stem/Stromal Cells - p. 564 6. Risks Associated With the In Vivo Protumorigenic and Proangiogenic Potential of Mesenchymal Stem/Stromal Cells - p. 565 7. Risks Related to Mesenchymal Stem/Stromal Cell-Induced Chemoresistance - p. 567 8. Mesenchymal Stem/Stromal Cells as Cellular Vehicles for Tumor Targeting: Advantages and Disadvantages - p. 569 9. Biodistribution and Long-term Safety of Mesenchymal Stem/Stromal Cells: What Is the Fate of MSCs In Vivo? - p. 571 10. Concluding Remarks and Future Perspectives - p. 573 11. Glossary - p. 574 12. List of Acronyms and Abbreviations - p. 575 13. 23. Concluding Remarks - p. 589 14. Index - p. 591
Mesenchymal stromal/ stem cells (MSCs) represent a heterogeneous cell population with immunomodulating, tissue repairing, differentiating, migratory and angiogenic abilities, making them important tools for clinical and translational research. An understanding of the role of MSCs in modulating tumor growth provides a glimpse into their role in non-pathological tissue remodeling and potential regenerative tissue therapies.
Mesenchymal Stromal Cells as Tumor Stromal Modulators is a comprehensive source for the understanding of the role of MSCs as ubiquitous connective tissue cell components, which may have both direct and indirect effects on the tumor microenvironment and potential for regenerative therapeutics for various diseases. Using cancer as a model disease, this book explores the transformative role MSCs play in the recruitment of disease cells, cell repair and immunological defenses.
1. Introduction - p. 552 2. Clinical Application of Ex Vivo Expanded Mesenchymal Stem/Stromal Cells - p. 552 3. Risks of Ex Vivo Expansion of Mesenchymal Stem/Stromal Cells - p. 556 4. Risks Related to Immunosuppression and Infection From Mesenchymal Stem/Stromal Cells - p. 561 5. Risks Related to Hypoimmunogenic Properties of Mesenchymal Stem/Stromal Cells - p. 564 6. Risks Associated With the In Vivo Protumorigenic and Proangiogenic Potential of Mesenchymal Stem/Stromal Cells - p. 565 7. Risks Related to Mesenchymal Stem/Stromal Cell-Induced Chemoresistance - p. 567 8. Mesenchymal Stem/Stromal Cells as Cellular Vehicles for Tumor Targeting: Advantages and Disadvantages - p. 569 9. Biodistribution and Long-term Safety of Mesenchymal Stem/Stromal Cells: What Is the Fate of MSCs In Vivo? - p. 571 10. Concluding Remarks and Future Perspectives - p. 573 11. Glossary - p. 574 12. List of Acronyms and Abbreviations - p. 575 13. 23. Concluding Remarks - p. 589 14. Index - p. 591
