This volume of Current Topics in Membranes focuses on metal transmembrane transporters and pumps, a recently discovered family of membrane proteins with many important roles in the physiology of living organisms. The book summarizes the most recent advances in the field of metal ion transport and provides a broad overview of the major classes of transporters involved in homeostasis of heavy metals. Various families of the transporters and metal specificities are discussed with the focus on the structural and mechanistic aspects of their function and regulation. The reader will access information obtained through a variety of approaches ranging from X-ray crystallography to cell biology and bioinformatics, which have been applied to transporters identified in diverse biological systems, such as pathogenic bacteria, plants, humans and others.
1. Cover image 2. Title page 3. Table of Contents 4. Series Editors 5. Copyright 6. Contributors 7. Preface 8. Previous Volumes in Series 9. Chapter One Transferrin-Mediated Cellular Iron Delivery 10. Chapter Two Structure, Function and Binding Selectivity and Stereoselectivity of Siderophore–Iron Outer Membrane Transporters 11. Chapter Three Iron Transport Machinery of Human Cells 12. Chapter Four Structure and Function of Copper Uptake Transporters 13. Chapter Five Toward a Molecular Understanding of Metal Transport by P1B-Type ATPases 14. Chapter Six Regulation of Copper Transporters in Human Cells 15. Chapter Seven Metal Export by CusCFBA, the Periplasmic Cu(I)/Ag(I) Transport System of Escherichia coli 16. Chapter Eight Molecular Architecture and Function of ZnT Transporters 17. Chapter Nine The Cation Selectivity of the ZIP Transporters 18. Chapter Ten Nramp 19. Chapter Eleven Genetic and Biochemical Approaches for Studying the Yellow Stripe-Like Transporter Family in Plants 20. Chapter Twelve Pathways of Arsenic Uptake and Efflux 21. Chapter Thirteen Extracellular Heme Uptake and the Challenges of Bacterial Cell Membranes 22. Chapter Fourteen The Mechanisms of Mg2+ and Co2+ Transport by the CorA Family of Divalent Cation Transporters 23. Index 24. Color Plates
This volume of Current Topics in Membranes focuses on metal transmembrane transporters and pumps, a recently discovered family of membrane proteins with many important roles in the physiology of living organisms. The book summarizes the most recent advances in the field of metal ion transport and provides a broad overview of the major classes of transporters involved in homeostasis of heavy metals. Various families of the transporters and metal specificities are discussed with the focus on the structural and mechanistic aspects of their function and regulation. The reader will access information obtained through a variety of approaches ranging from X-ray crystallography to cell biology and bioinformatics, which have been applied to transporters identified in diverse biological systems, such as pathogenic bacteria, plants, humans and others.
1. Cover image 2. Title page 3. Table of Contents 4. Series Editors 5. Copyright 6. Contributors 7. Preface 8. Previous Volumes in Series 9. Chapter One Transferrin-Mediated Cellular Iron Delivery 10. Chapter Two Structure, Function and Binding Selectivity and Stereoselectivity of Siderophore–Iron Outer Membrane Transporters 11. Chapter Three Iron Transport Machinery of Human Cells 12. Chapter Four Structure and Function of Copper Uptake Transporters 13. Chapter Five Toward a Molecular Understanding of Metal Transport by P1B-Type ATPases 14. Chapter Six Regulation of Copper Transporters in Human Cells 15. Chapter Seven Metal Export by CusCFBA, the Periplasmic Cu(I)/Ag(I) Transport System of Escherichia coli 16. Chapter Eight Molecular Architecture and Function of ZnT Transporters 17. Chapter Nine The Cation Selectivity of the ZIP Transporters 18. Chapter Ten Nramp 19. Chapter Eleven Genetic and Biochemical Approaches for Studying the Yellow Stripe-Like Transporter Family in Plants 20. Chapter Twelve Pathways of Arsenic Uptake and Efflux 21. Chapter Thirteen Extracellular Heme Uptake and the Challenges of Bacterial Cell Membranes 22. Chapter Fourteen The Mechanisms of Mg2+ and Co2+ Transport by the CorA Family of Divalent Cation Transporters 23. Index 24. Color Plates
