Metastatic Disease of the Nervous System, Volume 149, begins with an overview of the impact and range of direct neoplastic involvement of the central and peripheral nervous system, comprehensively reviewing all aspects of brain metastases, from clinical, radiological and neuropathological manifestations, to the roles of surgery, radiation, systemic and palliative therapy in their management, and the complications of these interventions. The clinical manifestations, diagnosis and treatment of leptomeningeal, dural, spinal epidural and plexus metastases are also covered in detail.
1. Cover image - p. iv 2. Title page - p. iv 3. Table of Contents - p. iv 4. Copyright - p. iv 5. Handbook of Clinical Neurology 3rd Series - p. v 6. Foreword - p. vii 7. Preface - p. ix 8. Contributors - p. xi 9. Section I: Overview - p. xi 10. Chapter 1: Overview of metastatic disease of the central nervous system - p. xi 11. Section II: Brain metastases - p. 23 12. Chapter 2: Brain metastases: epidemiology - p. 23 13. Chapter 3: Pathogenesis and biology - p. 42 14. Chapter 4: Role of the blood–brain barrier in metastatic disease of the central nervous system - p. 56 15. Chapter 5: Metastatic diseases of the central nervous system – neuropathologic aspects - p. 66 16. Chapter 6: Brain metastasis: clinical manifestations, symptom management, and palliative care - p. 73 17. Chapter 7: Brain metastases: neuroimaging - p. 88 18. Chapter 8: The role of surgery for brain metastases from solid tumors - p. 112 19. Chapter 9: Brain metastases: fractionated whole-brain radiotherapy - p. 121 20. Chapter 10: Brain metastases: radiosurgery - p. 127 21. Chapter 11: Systemic therapy for brain metastases - p. 135 22. Chapter 12: Neurocognitive aspects of brain metastasis - p. 153 23. Section III: Other nervous system metastases - p. 165 24. Chapter 13: Leptomeningeal metastasis - p. 165 25. Chapter 14: Intracranial dural, calvarial, and skull base metastases - p. 204 26. Chapter 15: Epidural and intramedullary spinal metastasis: clinical features and role of fractionated radiotherapy - p. 225 27. Chapter 16: Management – spinal metastases - p. 238 28. Chapter 17: Plexus and peripheral nerve metastasis - p. 255 29. Index - p. 281
Metastatic Disease of the Nervous System, Volume 149, begins with an overview of the impact and range of direct neoplastic involvement of the central and peripheral nervous system, comprehensively reviewing all aspects of brain metastases, from clinical, radiological and neuropathological manifestations, to the roles of surgery, radiation, systemic and palliative therapy in their management, and the complications of these interventions. The clinical manifestations, diagnosis and treatment of leptomeningeal, dural, spinal epidural and plexus metastases are also covered in detail.
1. Cover image - p. iv 2. Title page - p. iv 3. Table of Contents - p. iv 4. Copyright - p. iv 5. Handbook of Clinical Neurology 3rd Series - p. v 6. Foreword - p. vii 7. Preface - p. ix 8. Contributors - p. xi 9. Section I: Overview - p. xi 10. Chapter 1: Overview of metastatic disease of the central nervous system - p. xi 11. Section II: Brain metastases - p. 23 12. Chapter 2: Brain metastases: epidemiology - p. 23 13. Chapter 3: Pathogenesis and biology - p. 42 14. Chapter 4: Role of the blood–brain barrier in metastatic disease of the central nervous system - p. 56 15. Chapter 5: Metastatic diseases of the central nervous system – neuropathologic aspects - p. 66 16. Chapter 6: Brain metastasis: clinical manifestations, symptom management, and palliative care - p. 73 17. Chapter 7: Brain metastases: neuroimaging - p. 88 18. Chapter 8: The role of surgery for brain metastases from solid tumors - p. 112 19. Chapter 9: Brain metastases: fractionated whole-brain radiotherapy - p. 121 20. Chapter 10: Brain metastases: radiosurgery - p. 127 21. Chapter 11: Systemic therapy for brain metastases - p. 135 22. Chapter 12: Neurocognitive aspects of brain metastasis - p. 153 23. Section III: Other nervous system metastases - p. 165 24. Chapter 13: Leptomeningeal metastasis - p. 165 25. Chapter 14: Intracranial dural, calvarial, and skull base metastases - p. 204 26. Chapter 15: Epidural and intramedullary spinal metastasis: clinical features and role of fractionated radiotherapy - p. 225 27. Chapter 16: Management – spinal metastases - p. 238 28. Chapter 17: Plexus and peripheral nerve metastasis - p. 255 29. Index - p. 281
