Micro and Nano Systems for Biophysical Studies of Cells and Small Organisms provides a comprehensive introduction to the state-of-the-art micro and nano systems that have recently been developed and applied to biophysical studies of cells and small organisms. These micro and nano systems span from microelectromechanical systems (MEMS) and microfluidic devices to robotic micro-nanomanipulation systems. These biophysical studies range from cell mechanics to the neural science of worms and Drosophila. This book will help readers understand the fundamentals surrounding the development of these tools and teach them the most recent advances in cellular and organismal biophysics enabled by these technologies.
1. Title of Book - p. i 2. Cover image - p. i 3. Title page - p. ii 4. Table of Contents - p. iii 5. Copyright - p. iii 6. Contributors - p. ix 7. Preface - p. xiii 8. Chapter 1. Micro systems for probing cellular forces and cellular mechanical properties - p. 1 9. Chapter 2. Force-sensing micropillar arrays for cell mechanics and mechanobiology - p. 23 10. Chapter 3. Vertical nanostructures for probing live cells - p. 43 11. Chapter 4. Probing tissue mechanics at the cellular-length scale in cancer microenvironments - p. 90 12. Chapter 5. Advanced microfluidic devices for cell electroporation and manipulation - p. 105 13. Chapter 6. High-throughput three-dimensional cellular platforms for screening biophysical microenvironmental signals - p. 125 14. Chapter 7. Acoustofluidic technology for cell biophysics - p. 153 15. Chapter 8. Microfluidic devices for neutrophil migration studies - p. 173 16. Chapter 9. Field-controlled micro-nano manipulations and micro-nano robots - p. 201 17. Chapter 10. Robotic optical tweezers for cell biophysics - p. 227 18. Chapter 11. Robotic and microfluidic systems for single cell injection - p. 241 19. Biophysical phenotyping of C. elegans in a microfluidic chip for high-throughput drug screening - p. 261 20. Microfluidic devices for imaging and manipulation of C. elegans - p. 295 21. Micro systems for the study of behavioral responses of C. elegans to various physical and chemical stimuli - p. 323 22. Microfluidic devices to study the effect of electric fields on C. elegans and Danio rerio - p. 341 23. Force-controlled robotic systems for mechanical stimulation of Drosophila larvae - p. 363 24. Index - p. 381
Micro and Nano Systems for Biophysical Studies of Cells and Small Organisms provides a comprehensive introduction to the state-of-the-art micro and nano systems that have recently been developed and applied to biophysical studies of cells and small organisms. These micro and nano systems span from microelectromechanical systems (MEMS) and microfluidic devices to robotic micro-nanomanipulation systems. These biophysical studies range from cell mechanics to the neural science of worms and Drosophila. This book will help readers understand the fundamentals surrounding the development of these tools and teach them the most recent advances in cellular and organismal biophysics enabled by these technologies.
1. Title of Book - p. i 2. Cover image - p. i 3. Title page - p. ii 4. Table of Contents - p. iii 5. Copyright - p. iii 6. Contributors - p. ix 7. Preface - p. xiii 8. Chapter 1. Micro systems for probing cellular forces and cellular mechanical properties - p. 1 9. Chapter 2. Force-sensing micropillar arrays for cell mechanics and mechanobiology - p. 23 10. Chapter 3. Vertical nanostructures for probing live cells - p. 43 11. Chapter 4. Probing tissue mechanics at the cellular-length scale in cancer microenvironments - p. 90 12. Chapter 5. Advanced microfluidic devices for cell electroporation and manipulation - p. 105 13. Chapter 6. High-throughput three-dimensional cellular platforms for screening biophysical microenvironmental signals - p. 125 14. Chapter 7. Acoustofluidic technology for cell biophysics - p. 153 15. Chapter 8. Microfluidic devices for neutrophil migration studies - p. 173 16. Chapter 9. Field-controlled micro-nano manipulations and micro-nano robots - p. 201 17. Chapter 10. Robotic optical tweezers for cell biophysics - p. 227 18. Chapter 11. Robotic and microfluidic systems for single cell injection - p. 241 19. Biophysical phenotyping of C. elegans in a microfluidic chip for high-throughput drug screening - p. 261 20. Microfluidic devices for imaging and manipulation of C. elegans - p. 295 21. Micro systems for the study of behavioral responses of C. elegans to various physical and chemical stimuli - p. 323 22. Microfluidic devices to study the effect of electric fields on C. elegans and Danio rerio - p. 341 23. Force-controlled robotic systems for mechanical stimulation of Drosophila larvae - p. 363 24. Index - p. 381
