As both a practical reference for clinicians and researchers and an effective self-assessment tool for board preparation, Middleton's Allergy: Principles and Practice remains the #1 authoritative resource in the field. This fully revised 10th Edition brings you up to date with recent advancements in basic science and clinical applications regarding allergy practice and disease mechanisms, offering unparalleled guidance on the full spectrum of allergy across the lifespan.
1. Cover image - p. c 2. Title page - p. iii 3. Copyright - p. iv 4. Contributors - p. v 5. Foreword - p. xvii 6. Preface - p. xviii 7. Table of Contents - p. xix 8. VOLUME 1 - p. v1 9. SECTION A Basic Sciences Underlying Allergy and Immunology - p. p1 10. 1 Innate Immunity - p. 1 11. 2 Adaptive Immunity - p. 21 12. 3 Immunoglobulin Structure and Function - p. 31 13. 4 Immune Tolerance - p. 47 14. 5 Cytokines in Allergic Inflammation - p. 73 15. 6 Cellular Adhesion in Inflammation - p. 90 16. 7 Chemokines - p. 104 17. 8 The Complement System - p. 120 18. 9 Lipid Mediators of Hypersensitivity and Inflammation - p. 140 19. 10 Molecular Biology and Genetic Engineering - p. 163 20. 11 Biology of Lymphocytes - p. 188 21. 12 Innate Lymphoid Cells - p. 204 22. 13 Antigen Presenting Dendritic Cells - p. 216 23. 14 Biology of Mast Cells and Their Mediators - p. 230 24. 15 Biology of Basophils - p. 260 25. 16 Biology of Eosinophils - p. 273 26. 17 Biology of Neutrophils - p. 285 27. 18 Biology of Monocytes and Macrophages - p. 297 28. 19 Airway Epithelial Cells - p. 308 29. 20 Airway Smooth Muscle in Asthma - p. 324 30. 21 Pathophysiology of Allergic Inflammation - p. 341 31. 22 Genetics and Epigenetics in Allergic Diseases - p. 357 32. 23 Omic and Systems Biology Approaches to Allergic Disease - p. 376 33. 24 Immunobiology of IgE and IgE Receptors - p. 387 34. 25 Neuronal Control of Airway Function in Allergy - p. 400 35. Section B Aerobiology and Allergens - p. p413 36. 26 The Structure and Function of Allergens - p. 413 37. 27 Aerobiology of Outdoor Allergens - p. 452 38. 28 Indoor Allergens - p. 478 39. 29 Preparation and Standardization of Allergens and Allergen Extracts* - p. 496 40. 30 Air Pollution: Indoor and Outdoor - p. 508 41. Section C The Skin - p. p529 42. 31 Structure of the Skin and Cutaneous Immunology - p. 529 43. 32 Atopic Dermatitis - p. 550 44. 33 Contact Dermatitis - p. 575 45. 34 Urticaria and Angioedema - p. 584 46. 35 Hereditary Angioedema and Bradykinin-Mediated Angioedema - p. 601 47. 36 Immune Complexes in Disease - p. 617 48. Section D The Eye - p. p637 49. 37 Allergic Diseases of the Eye - p. 637 50. Section E Respiratory Tract - p. p657 51. 38 The Nose and Control of Nasal Airflow - p. 657 52. 39 Allergic and Nonallergic Rhinitis - p. 668 53. 40 Rhinosinusitis and Nasal Polyps - p. 694 54. 41 Development, Structure, and Physiology in Normal Lung and in Asthma - p. 706 55. 42 Respiratory Tract Mucosal Immunology - p. 721 56. 43 Airway Mucus and the Mucociliary System - p. 738 57. 44 Epidemiology of Asthma and Allergic Diseases - p. 751 58. 45 Ontogeny of Immune Development and Its Relationship to Allergic Diseases and Asthma - p. 783 59. 46 Climate Change: Allergic Diseases and Asthma - p. 806 60. 47 Mouse Models of Allergic Airways Disease - p. 828 61. 48 Diagnosis of Asthma in Infants and Children - p. 850 62. 49 Management of Asthma in Infants and Children - p. 865 63. 50 Diagnosis of Asthma in Adults - p. 877 64. 51 Management of Asthma in Adolescents and Adults - p. 888 65. 52 Emergency Treatment and Approach to the Patient With Acute Asthma - p. 925 66. 53 Approach to the Patient With Exercise-Induced Bronchoconstriction - p. 942 67. 54 Asthma and Allergic Diseases During Pregnancy - p. 956 68. 55 Occupational Allergy and Asthma - p. 981 69. 56 Pathology of Asthma - p. 997 70. 57 Allergic Bronchopulmonary Aspergillosis, Hypersensitivity Pneumonitis, and Epidemic Thunderstorm Asthma - p. 1011 71. 58 Immunologic Nonasthmatic Diseases of the Lung - p. 1029 72. 59 Approaches to the Patient With Chronic Cough - p. 1050 73. 60 Bronchial and Nasal Challenge Testing - p. 1062 74. 61 Lung Imaging - p. 1089 75. 62 Pharmaceutical Aerosols and Aerosol Drug Delivery Systems - p. 1102 76. VOLUME 2 - p. v1119 77. SECTION F Gastrointestinal Tract - p. p1119 78. 63 Gastrointestinal Mucosal Immunology - p. 1119 79. 64 Eosinophilic Gastrointestinal Disorders - p. 1129 80. Section G Systemic Disease - p. p1141 81. 65 Clinical Significance of Immunoglobulin E - p. 1141 82. 66 In Vivo Methods for the Study and Diagnosis of IgE-Mediated Allergy - p. 1152 83. 67 Approach to the Patient With Recurrent Infections - p. 1166 84. 68 Primary Immunodeficiency Diseases - p. 1178 85. 69 Treatment of Primary Immunodeficiency Diseases - p. 1208 86. 70 HIV Infection and Allergic Disease - p. 1225 87. 71 Laboratory Tests for Allergic and Immunodeficiency Diseases - p. 1238 88. 72 Eosinophilia and Eosinophil-Related Disorders - p. 1255 89. 73 Mastocytosis - p. 1275 90. 74 Anaphylaxis - p. 1287 91. 75 Insect Allergy - p. 1308 92. 76 Drug Allergy - p. 1325 93. 77 Hypersensitivity to Aspirin and Other Nonsteroidal Antiinflammatory Drugs - p. 1350 94. 78 Reactions to Foods - p. 1361 95. 79 Oral Food Challenge Testing - p. 1395 96. 80 Food Allergy Management, Prevention, and Therapy - p. 1403 97. 81 Adverse Reactions to Vaccines - p. 1430 98. Section H Therapeutics - p. p1453 99. 82 Allergen Immunotherapy for Inhalant Allergens - p. 1453 100. 83 Principles of Pharmacotherapeutics - p. 1486 101. 84 Precision Medicine in Allergic Disorders - p. 1498 102. 85 Optimizing Adherence in Practice - p. 1511 103. 86 Anti-Immunoglobulin E Therapy - p. 1520 104. 87 Cytokine-Specific Therapy in Asthma - p. 1535 105. 88 Histamine and Antihistamines* - p. 1551 106. 89 Inhaled β2-Agonists - p. 1583 107. 90 Anticholinergic Therapies - p. 1591 108. 91 Glucocorticoids - p. 1605 109. 92 Antileukotriene Therapy in Asthma - p. 1630 110. 93 Unconventional Theories and Unproven Methods in Allergy - p. 1646 111. 94 Complementary and Integrative Health - p. 1659 112. CD Molecules - p. 1687 113. Index - p. I1
As both a practical reference for clinicians and researchers and an effective self-assessment tool for board preparation, Middleton's Allergy: Principles and Practice remains the #1 authoritative resource in the field. This fully revised 10th Edition brings you up to date with recent advancements in basic science and clinical applications regarding allergy practice and disease mechanisms, offering unparalleled guidance on the full spectrum of allergy across the lifespan.
1. Cover image - p. c 2. Title page - p. iii 3. Copyright - p. iv 4. Contributors - p. v 5. Foreword - p. xvii 6. Preface - p. xviii 7. Table of Contents - p. xix 8. VOLUME 1 - p. v1 9. SECTION A Basic Sciences Underlying Allergy and Immunology - p. p1 10. 1 Innate Immunity - p. 1 11. 2 Adaptive Immunity - p. 21 12. 3 Immunoglobulin Structure and Function - p. 31 13. 4 Immune Tolerance - p. 47 14. 5 Cytokines in Allergic Inflammation - p. 73 15. 6 Cellular Adhesion in Inflammation - p. 90 16. 7 Chemokines - p. 104 17. 8 The Complement System - p. 120 18. 9 Lipid Mediators of Hypersensitivity and Inflammation - p. 140 19. 10 Molecular Biology and Genetic Engineering - p. 163 20. 11 Biology of Lymphocytes - p. 188 21. 12 Innate Lymphoid Cells - p. 204 22. 13 Antigen Presenting Dendritic Cells - p. 216 23. 14 Biology of Mast Cells and Their Mediators - p. 230 24. 15 Biology of Basophils - p. 260 25. 16 Biology of Eosinophils - p. 273 26. 17 Biology of Neutrophils - p. 285 27. 18 Biology of Monocytes and Macrophages - p. 297 28. 19 Airway Epithelial Cells - p. 308 29. 20 Airway Smooth Muscle in Asthma - p. 324 30. 21 Pathophysiology of Allergic Inflammation - p. 341 31. 22 Genetics and Epigenetics in Allergic Diseases - p. 357 32. 23 Omic and Systems Biology Approaches to Allergic Disease - p. 376 33. 24 Immunobiology of IgE and IgE Receptors - p. 387 34. 25 Neuronal Control of Airway Function in Allergy - p. 400 35. Section B Aerobiology and Allergens - p. p413 36. 26 The Structure and Function of Allergens - p. 413 37. 27 Aerobiology of Outdoor Allergens - p. 452 38. 28 Indoor Allergens - p. 478 39. 29 Preparation and Standardization of Allergens and Allergen Extracts* - p. 496 40. 30 Air Pollution: Indoor and Outdoor - p. 508 41. Section C The Skin - p. p529 42. 31 Structure of the Skin and Cutaneous Immunology - p. 529 43. 32 Atopic Dermatitis - p. 550 44. 33 Contact Dermatitis - p. 575 45. 34 Urticaria and Angioedema - p. 584 46. 35 Hereditary Angioedema and Bradykinin-Mediated Angioedema - p. 601 47. 36 Immune Complexes in Disease - p. 617 48. Section D The Eye - p. p637 49. 37 Allergic Diseases of the Eye - p. 637 50. Section E Respiratory Tract - p. p657 51. 38 The Nose and Control of Nasal Airflow - p. 657 52. 39 Allergic and Nonallergic Rhinitis - p. 668 53. 40 Rhinosinusitis and Nasal Polyps - p. 694 54. 41 Development, Structure, and Physiology in Normal Lung and in Asthma - p. 706 55. 42 Respiratory Tract Mucosal Immunology - p. 721 56. 43 Airway Mucus and the Mucociliary System - p. 738 57. 44 Epidemiology of Asthma and Allergic Diseases - p. 751 58. 45 Ontogeny of Immune Development and Its Relationship to Allergic Diseases and Asthma - p. 783 59. 46 Climate Change: Allergic Diseases and Asthma - p. 806 60. 47 Mouse Models of Allergic Airways Disease - p. 828 61. 48 Diagnosis of Asthma in Infants and Children - p. 850 62. 49 Management of Asthma in Infants and Children - p. 865 63. 50 Diagnosis of Asthma in Adults - p. 877 64. 51 Management of Asthma in Adolescents and Adults - p. 888 65. 52 Emergency Treatment and Approach to the Patient With Acute Asthma - p. 925 66. 53 Approach to the Patient With Exercise-Induced Bronchoconstriction - p. 942 67. 54 Asthma and Allergic Diseases During Pregnancy - p. 956 68. 55 Occupational Allergy and Asthma - p. 981 69. 56 Pathology of Asthma - p. 997 70. 57 Allergic Bronchopulmonary Aspergillosis, Hypersensitivity Pneumonitis, and Epidemic Thunderstorm Asthma - p. 1011 71. 58 Immunologic Nonasthmatic Diseases of the Lung - p. 1029 72. 59 Approaches to the Patient With Chronic Cough - p. 1050 73. 60 Bronchial and Nasal Challenge Testing - p. 1062 74. 61 Lung Imaging - p. 1089 75. 62 Pharmaceutical Aerosols and Aerosol Drug Delivery Systems - p. 1102 76. VOLUME 2 - p. v1119 77. SECTION F Gastrointestinal Tract - p. p1119 78. 63 Gastrointestinal Mucosal Immunology - p. 1119 79. 64 Eosinophilic Gastrointestinal Disorders - p. 1129 80. Section G Systemic Disease - p. p1141 81. 65 Clinical Significance of Immunoglobulin E - p. 1141 82. 66 In Vivo Methods for the Study and Diagnosis of IgE-Mediated Allergy - p. 1152 83. 67 Approach to the Patient With Recurrent Infections - p. 1166 84. 68 Primary Immunodeficiency Diseases - p. 1178 85. 69 Treatment of Primary Immunodeficiency Diseases - p. 1208 86. 70 HIV Infection and Allergic Disease - p. 1225 87. 71 Laboratory Tests for Allergic and Immunodeficiency Diseases - p. 1238 88. 72 Eosinophilia and Eosinophil-Related Disorders - p. 1255 89. 73 Mastocytosis - p. 1275 90. 74 Anaphylaxis - p. 1287 91. 75 Insect Allergy - p. 1308 92. 76 Drug Allergy - p. 1325 93. 77 Hypersensitivity to Aspirin and Other Nonsteroidal Antiinflammatory Drugs - p. 1350 94. 78 Reactions to Foods - p. 1361 95. 79 Oral Food Challenge Testing - p. 1395 96. 80 Food Allergy Management, Prevention, and Therapy - p. 1403 97. 81 Adverse Reactions to Vaccines - p. 1430 98. Section H Therapeutics - p. p1453 99. 82 Allergen Immunotherapy for Inhalant Allergens - p. 1453 100. 83 Principles of Pharmacotherapeutics - p. 1486 101. 84 Precision Medicine in Allergic Disorders - p. 1498 102. 85 Optimizing Adherence in Practice - p. 1511 103. 86 Anti-Immunoglobulin E Therapy - p. 1520 104. 87 Cytokine-Specific Therapy in Asthma - p. 1535 105. 88 Histamine and Antihistamines* - p. 1551 106. 89 Inhaled β2-Agonists - p. 1583 107. 90 Anticholinergic Therapies - p. 1591 108. 91 Glucocorticoids - p. 1605 109. 92 Antileukotriene Therapy in Asthma - p. 1630 110. 93 Unconventional Theories and Unproven Methods in Allergy - p. 1646 111. 94 Complementary and Integrative Health - p. 1659 112. CD Molecules - p. 1687 113. Index - p. I1
