Through eight outstanding editions, Middleton’s Allergy: Principles and Practice has been the reference of choice for both clinicians and researchers as both a practical reference and an effective self-assessment tool for board preparation. The 9th Edition continues the tradition of excellence with comprehensive coverage of all basic science and clinical applications regarding allergy practice and disease mechanisms. It brings you fully up to date with recent innovations in the diagnosis, prevention, and management of allergic disorders, including emerging global issues, the advent of precision medicine, and new immunologic therapies.
1. Cover image - p. Cover 2. Title page - p. ii 3. Table of Contents - p. iii 4. Copyright - p. iii 5. Foreword - p. iii 6. Preface - p. iii 7. List of Contributors - p. iii 8. List of Illustrations - p. iii 9. List of Tables - p. iii 10. Volume 1 - p. iii 11. Section A: Basic Sciences Underlying Allergy and Immunology - p. iii 12. Chapter 1: Innate Immunity - p. iii 13. Chapter 2: Adaptive Immunity - p. iii 14. Chapter 3: Immunoglobulin Structure and Function - p. iii 15. Chapter 4: Immune Tolerance - p. iii 16. Chapter 5: Cytokines in Allergic Inflammation - p. iii 17. Chapter 6: Cellular Adhesion in Inflammation - p. iii 18. Chapter 7: Chemokines - p. iii 19. Chapter 8: The Complement System - p. iii 20. Chapter 9: Lipid Mediators of Hypersensitivity and Inflammation - p. iii 21. Chapter 10: Molecular Biology and Genetic Engineering - p. iii 22. Chapter 11: Biology of Lymphocytes - p. iii 23. Chapter 12: Innate Lymphoid Cells - p. iii 24. Chapter 13: Antigen-Presenting Dendritic Cells - p. iii 25. Chapter 14: Biology of Mast Cells and Their Mediators - p. iii 26. Chapter 15: Biology of Basophils - p. iii 27. Chapter 16: Biology of Eosinophils - p. iii 28. Chapter 17: Biology of Neutrophils - p. iii 29. Chapter 18: Biology of Monocytes and Macrophages - p. iii 30. Chapter 19: Airway Epithelial Cells - p. iii 31. Chapter 20: Airway Smooth Muscle in Asthma - p. iii 32. Chapter 21: Pathophysiology of Allergic Inflammation - p. iii 33. Chapter 22: Genetics and Epigenetics in Allergic Diseases and Asthma - p. iii 34. Chapter 23: Systems Biology - p. iii 35. Chapter 24: Immunobiology of IgE and IgE Receptors - p. iii 36. Chapter 25: Neuronal Control of Airway Function in Allergy - p. iii 37. Section B: Aerobiology and Allergens - p. iii 38. Chapter 26: The Structure and Function of Allergens - p. iii 39. Chapter 27: Aerobiology of Outdoor Allergens - p. iii 40. Chapter 28: Indoor Allergens - p. iii 41. Chapter 29: Preparation and Standardization of Allergen Extracts* - p. iii 42. Chapter 30: Air Pollution: Indoor and Outdoor - p. iii 43. Chapter 31: Effect of the Food Matrix and Processing on the Allergenic Activity of Foods - p. iii 44. Section C: The Skin - p. iii 45. Chapter 32: Structure of the Skin and Cutaneous Immunology - p. iii 46. Chapter 33: Atopic Dermatitis - p. iii 47. Chapter 34: Contact Dermatitis - p. iii 48. Chapter 35: Urticaria and Angioedema - p. iii 49. Chapter 36: Hereditary Angioedema and Bradykinin-Mediated Angioedema - p. iii 50. Chapter 37: Immune Complexes and Allergic Disease - p. iii 51. Section D: The Eye - p. iii 52. Chapter 38: Allergic and Immunologic Diseases of the Eye - p. iii 53. Section E: Respiratory Tract - p. iii 54. Chapter 39: The Nose and Control of Nasal Airflow - p. iii 55. Chapter 40: Allergic and Nonallergic Rhinitis - p. iii 56. Chapter 41: Rhinosinusitis and Nasal Polyps - p. iii 57. Chapter 42: Development, Structure and Physiology in Normal Lung and in Asthma - p. iii 58. Chapter 43: Respiratory Tract Mucosal Immunology - p. iii 59. Chapter 44: Airway Mucus and Mucociliary System - p. iii 60. Chapter 45: Epidemiology of Asthma and Allergic Diseases - p. iii 61. Chapter 46: Ontogeny of Immune Development and Its Relationship to Allergic Diseases and Asthma - p. iii 62. Chapter 47: Asthma Pathogenesis - p. iii 63. Chapter 48: Mouse Models of Allergic Airways Disease - p. iii 64. Chapter 49: Diagnosis of Asthma in Infants and Children - p. iii 65. Chapter 50: Management of Asthma in Infants and Children - p. iii 66. Chapter 51: Diagnosis of Asthma in Adults - p. iii 67. Chapter 52: Management of Asthma in Adolescents and Adults - p. iii 68. Chapter 53: Emergency Treatment and Approach to the Patient with Acute Asthma - p. iii 69. Chapter 54: Approach to the Patient with Exercise-Induced Bronchoconstriction - p. iii 70. Chapter 55: Asthma and Allergic Diseases During Pregnancy - p. iii 71. Chapter 56: Occupational Allergy and Asthma - p. iii 72. Chapter 57: Pathology of Asthma - p. iii 73. Chapter 58: Allergic Bronchopulmonary Aspergillosis, Hypersensitivity Pneumonitis, and Epidemic Thunderstorm Asthma - p. iii 74. Chapter 59: Immunologic Nonasthmatic Diseases of the Lung - p. g0040 75. Chapter 60: Approach to the Patient with Chronic Cough - p. g0040 76. Chapter 61: Bronchial and Nasal Challenge Testing - p. g0040 77. Chapter 62: Lung Imaging - p. g0040 78. Chapter 63: Aerosols and Aerosol Drug Delivery Systems - p. g0040 79. Volume 2 - p. g0040 80. Section F: Gastrointestinal Tract - p. g0040 81. Chapter 64: Gastrointestinal Mucosal Immunology - p. g0040 82. Chapter 65: Eosinophilic Gastrointestinal Disorders - p. g0040 83. Section G: Systemic Disease - p. g0040 84. Chapter 66: Clinical Significance of Immunoglobulin E - p. g0040 85. Chapter 67: In Vivo Methods for the Study and Diagnosis of Allergy - p. g0040 86. Chapter 68: Approach to the Patient with Recurrent Infections - p. g0040 87. Chapter 69: Primary Immunodeficiency Diseases - p. g0040 88. Chapter 70: Treatment of Primary Immunodeficiency Diseases - p. g0040 89. Chapter 71: HIV Infection and Allergic Disease - p. g0040 90. Chapter 72: Laboratory Tests for Allergic and Immunodeficiency Diseases - p. g0040 91. Chapter 73: Eosinophilia and Eosinophil-Related Disorders - p. g0040 92. Chapter 74: Mastocytosis - p. g0040 93. Chapter 75: Anaphylaxis - p. g0040 94. Chapter 76: Insect Allergy - p. g0040 95. Chapter 77: Drug Allergy - p. g0040 96. Chapter 78: Hypersensitivity to Aspirin and Other Nonsteroidal Antiinflammatory Drugs - p. g0040 97. Chapter 79: Reactions to Foods - p. g0040 98. Chapter 80: Reactions to Food and Drug Additives - p. g0040 99. Chapter 81: Oral Food Challenge Testing - p. g0040 100. Chapter 82: Food Allergy Management - p. g0040 101. Chapter 83: Adverse Reactions to Vaccines - p. g0040 102. Section H: Therapeutics - p. g0040 103. Chapter 84: Allergen Control for Prevention and Management of Allergic Diseases - p. g0040 104. Chapter 85: Injection Immunotherapy for Inhalant Allergens - p. g0040 105. Chapter 86: Sublingual Immunotherapy for Inhalant Allergens - p. g0040 106. Chapter 87: Principles of Pharmacotherapeutics - p. g0040 107. Chapter 88: Precision Medicine in Allergic Disorders - p. g0040 108. Chapter 89: Adherence - p. g0040 109. Chapter 90: Anti-Immunoglobulin E Therapy - p. g0040 110. Chapter 91: Cytokine-Specific Therapy in Asthma - p. g0040 111. Chapter 92: Histamine and Antihistamines - p. g0040 112. Chapter 93: Inhaled β2-Agonists - p. g0040 113. Chapter 94: Xanthines, Phosphodiesterase Inhibitors, and Chromones - p. g0040 114. Chapter 95: Anticholinergic Therapies - p. g0040 115. Chapter 96: Glucocorticoids - p. g0040 116. Chapter 97: Antileukotriene Therapy in Asthma - p. g0040 117. Chapter 98: Unconventional Theories and Unproven Methods in Allergy - p. g0040 118. Chapter 99: Complementary and Alternative Medicine - p. g0040 119. CD Molecules - p. g0040 120. Answers - p. g0040 121. Index - p. g0040
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Through eight outstanding editions, Middleton’s Allergy: Principles and Practice has been the reference of choice for both clinicians and researchers as both a practical reference and an effective self-assessment tool for board preparation. The 9th Edition continues the tradition of excellence with comprehensive coverage of all basic science and clinical applications regarding allergy practice and disease mechanisms. It brings you fully up to date with recent innovations in the diagnosis, prevention, and management of allergic disorders, including emerging global issues, the advent of precision medicine, and new immunologic therapies.
1. Cover image - p. Cover 2. Title page - p. ii 3. Table of Contents - p. iii 4. Copyright - p. iii 5. Foreword - p. iii 6. Preface - p. iii 7. List of Contributors - p. iii 8. List of Illustrations - p. iii 9. List of Tables - p. iii 10. Volume 1 - p. iii 11. Section A: Basic Sciences Underlying Allergy and Immunology - p. iii 12. Chapter 1: Innate Immunity - p. iii 13. Chapter 2: Adaptive Immunity - p. iii 14. Chapter 3: Immunoglobulin Structure and Function - p. iii 15. Chapter 4: Immune Tolerance - p. iii 16. Chapter 5: Cytokines in Allergic Inflammation - p. iii 17. Chapter 6: Cellular Adhesion in Inflammation - p. iii 18. Chapter 7: Chemokines - p. iii 19. Chapter 8: The Complement System - p. iii 20. Chapter 9: Lipid Mediators of Hypersensitivity and Inflammation - p. iii 21. Chapter 10: Molecular Biology and Genetic Engineering - p. iii 22. Chapter 11: Biology of Lymphocytes - p. iii 23. Chapter 12: Innate Lymphoid Cells - p. iii 24. Chapter 13: Antigen-Presenting Dendritic Cells - p. iii 25. Chapter 14: Biology of Mast Cells and Their Mediators - p. iii 26. Chapter 15: Biology of Basophils - p. iii 27. Chapter 16: Biology of Eosinophils - p. iii 28. Chapter 17: Biology of Neutrophils - p. iii 29. Chapter 18: Biology of Monocytes and Macrophages - p. iii 30. Chapter 19: Airway Epithelial Cells - p. iii 31. Chapter 20: Airway Smooth Muscle in Asthma - p. iii 32. Chapter 21: Pathophysiology of Allergic Inflammation - p. iii 33. Chapter 22: Genetics and Epigenetics in Allergic Diseases and Asthma - p. iii 34. Chapter 23: Systems Biology - p. iii 35. Chapter 24: Immunobiology of IgE and IgE Receptors - p. iii 36. Chapter 25: Neuronal Control of Airway Function in Allergy - p. iii 37. Section B: Aerobiology and Allergens - p. iii 38. Chapter 26: The Structure and Function of Allergens - p. iii 39. Chapter 27: Aerobiology of Outdoor Allergens - p. iii 40. Chapter 28: Indoor Allergens - p. iii 41. Chapter 29: Preparation and Standardization of Allergen Extracts* - p. iii 42. Chapter 30: Air Pollution: Indoor and Outdoor - p. iii 43. Chapter 31: Effect of the Food Matrix and Processing on the Allergenic Activity of Foods - p. iii 44. Section C: The Skin - p. iii 45. Chapter 32: Structure of the Skin and Cutaneous Immunology - p. iii 46. Chapter 33: Atopic Dermatitis - p. iii 47. Chapter 34: Contact Dermatitis - p. iii 48. Chapter 35: Urticaria and Angioedema - p. iii 49. Chapter 36: Hereditary Angioedema and Bradykinin-Mediated Angioedema - p. iii 50. Chapter 37: Immune Complexes and Allergic Disease - p. iii 51. Section D: The Eye - p. iii 52. Chapter 38: Allergic and Immunologic Diseases of the Eye - p. iii 53. Section E: Respiratory Tract - p. iii 54. Chapter 39: The Nose and Control of Nasal Airflow - p. iii 55. Chapter 40: Allergic and Nonallergic Rhinitis - p. iii 56. Chapter 41: Rhinosinusitis and Nasal Polyps - p. iii 57. Chapter 42: Development, Structure and Physiology in Normal Lung and in Asthma - p. iii 58. Chapter 43: Respiratory Tract Mucosal Immunology - p. iii 59. Chapter 44: Airway Mucus and Mucociliary System - p. iii 60. Chapter 45: Epidemiology of Asthma and Allergic Diseases - p. iii 61. Chapter 46: Ontogeny of Immune Development and Its Relationship to Allergic Diseases and Asthma - p. iii 62. Chapter 47: Asthma Pathogenesis - p. iii 63. Chapter 48: Mouse Models of Allergic Airways Disease - p. iii 64. Chapter 49: Diagnosis of Asthma in Infants and Children - p. iii 65. Chapter 50: Management of Asthma in Infants and Children - p. iii 66. Chapter 51: Diagnosis of Asthma in Adults - p. iii 67. Chapter 52: Management of Asthma in Adolescents and Adults - p. iii 68. Chapter 53: Emergency Treatment and Approach to the Patient with Acute Asthma - p. iii 69. Chapter 54: Approach to the Patient with Exercise-Induced Bronchoconstriction - p. iii 70. Chapter 55: Asthma and Allergic Diseases During Pregnancy - p. iii 71. Chapter 56: Occupational Allergy and Asthma - p. iii 72. Chapter 57: Pathology of Asthma - p. iii 73. Chapter 58: Allergic Bronchopulmonary Aspergillosis, Hypersensitivity Pneumonitis, and Epidemic Thunderstorm Asthma - p. iii 74. Chapter 59: Immunologic Nonasthmatic Diseases of the Lung - p. g0040 75. Chapter 60: Approach to the Patient with Chronic Cough - p. g0040 76. Chapter 61: Bronchial and Nasal Challenge Testing - p. g0040 77. Chapter 62: Lung Imaging - p. g0040 78. Chapter 63: Aerosols and Aerosol Drug Delivery Systems - p. g0040 79. Volume 2 - p. g0040 80. Section F: Gastrointestinal Tract - p. g0040 81. Chapter 64: Gastrointestinal Mucosal Immunology - p. g0040 82. Chapter 65: Eosinophilic Gastrointestinal Disorders - p. g0040 83. Section G: Systemic Disease - p. g0040 84. Chapter 66: Clinical Significance of Immunoglobulin E - p. g0040 85. Chapter 67: In Vivo Methods for the Study and Diagnosis of Allergy - p. g0040 86. Chapter 68: Approach to the Patient with Recurrent Infections - p. g0040 87. Chapter 69: Primary Immunodeficiency Diseases - p. g0040 88. Chapter 70: Treatment of Primary Immunodeficiency Diseases - p. g0040 89. Chapter 71: HIV Infection and Allergic Disease - p. g0040 90. Chapter 72: Laboratory Tests for Allergic and Immunodeficiency Diseases - p. g0040 91. Chapter 73: Eosinophilia and Eosinophil-Related Disorders - p. g0040 92. Chapter 74: Mastocytosis - p. g0040 93. Chapter 75: Anaphylaxis - p. g0040 94. Chapter 76: Insect Allergy - p. g0040 95. Chapter 77: Drug Allergy - p. g0040 96. Chapter 78: Hypersensitivity to Aspirin and Other Nonsteroidal Antiinflammatory Drugs - p. g0040 97. Chapter 79: Reactions to Foods - p. g0040 98. Chapter 80: Reactions to Food and Drug Additives - p. g0040 99. Chapter 81: Oral Food Challenge Testing - p. g0040 100. Chapter 82: Food Allergy Management - p. g0040 101. Chapter 83: Adverse Reactions to Vaccines - p. g0040 102. Section H: Therapeutics - p. g0040 103. Chapter 84: Allergen Control for Prevention and Management of Allergic Diseases - p. g0040 104. Chapter 85: Injection Immunotherapy for Inhalant Allergens - p. g0040 105. Chapter 86: Sublingual Immunotherapy for Inhalant Allergens - p. g0040 106. Chapter 87: Principles of Pharmacotherapeutics - p. g0040 107. Chapter 88: Precision Medicine in Allergic Disorders - p. g0040 108. Chapter 89: Adherence - p. g0040 109. Chapter 90: Anti-Immunoglobulin E Therapy - p. g0040 110. Chapter 91: Cytokine-Specific Therapy in Asthma - p. g0040 111. Chapter 92: Histamine and Antihistamines - p. g0040 112. Chapter 93: Inhaled β2-Agonists - p. g0040 113. Chapter 94: Xanthines, Phosphodiesterase Inhibitors, and Chromones - p. g0040 114. Chapter 95: Anticholinergic Therapies - p. g0040 115. Chapter 96: Glucocorticoids - p. g0040 116. Chapter 97: Antileukotriene Therapy in Asthma - p. g0040 117. Chapter 98: Unconventional Theories and Unproven Methods in Allergy - p. g0040 118. Chapter 99: Complementary and Alternative Medicine - p. g0040 119. CD Molecules - p. g0040 120. Answers - p. g0040 121. Index - p. g0040
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