Despite extraordinary therapeutic advances since the discovery of insulin 100 years ago, diabetes prevalence continues to rise and significant challenges remain. Modern Diabetology: Basic Science and Clinical Practice provides a concise, one-stop reference that consolidates rapidly evolving research and clinical practice guidelines for today’s endocrinologists, general surgeons, internists, and primary care physicians.
1. Cover image - p. c 2. Title page - p. iii 3. Copyright - p. iv 4. Contributors - p. v 5. Reviewers - p. xi 6. Preface - p. xiii 7. Contents - p. xv 8. SECTION I Regulation of Gene Expression, Hormone Synthesis, and Hormone Secretion - p. 1 9. 1 Pancreatic Development in the Context of Diabetes - p. 2 10. 2 Glucagon: From Gene Regulation to Secretion - p. 17 11. 3 Insulin Production, Processing, and Secretion - p. 31 12. 4 Incretins: From Gene Expression to Secretion and Action of GLP-1 and GIP - p. 42 13. Section II Hormone Action - p. 65 14. 5 Glucagon Synthesis, Secretion, and Mechanisms of Action - p. 66 15. 6 Insulin Structure and Function - p. 78 16. 7 Common Mechanisms of Insulin Signaling, Action, and Resistance - p. 89 17. 8 Insulin Receptor Structure and Function - p. 108 18. 9 Insulin Action in Liver, Skeletal, Muscle, and Adipose Tissue: A Focus on Humans - p. 125 19. 10 Insulin Action in the Brain - p. 138 20. 11 Insulin Action in the Cardiovascular System - p. 152 21. 12 Metabolic Regulation by Adipokines, Hepatokines, and Myokines - p. 168 22. Section III Genetics of Diabetes - p. 179 23. 13 Genetics of Monogenic Forms of Diabetes - p. 180 24. 14 Genetics of Type 1 Diabetes - p. 190 25. 15 Genetics of Type 2 Diabetes - p. 209 26. Section IV Type 1 Diabetes - p. 223 27. 16 Spotlight on the Pathology of Type 1 Diabetes - p. 224 28. Section V Type 2 Diabetes - p. 239 29. 17 Heterogeneity of Type 2 Diabetes Mellitus - p. 240 30. 18 Cystic Fibrosis–Related Diabetes - p. 253 31. Section VI Complications of Diabetes - p. 265 32. 19 Intranuclear Beta Cell Nrf2 Expression in Type 2 Diabetes and the Potential Use of Glutathione Peroxidase Mimetics for Early Treatment - p. 266 33. 20 Diabetic Retinal Disease - p. 273 34. 21 Understanding Diabetic Neuropathy: From Pathophysiology to Therapeutic Targets - p. 288 35. Section VII Pharmacology and Drugs - p. 303 36. 22 SGLT2 Inhibitors and Slowing Kidney Disease Progression From Diabetes - p. 304 37. 23 Advanced Technology in Diabetes: Sensors and Pumps - p. 317 38. 24 Pancreas and Islet Cell Transplantation for Diabetes - p. 336 39. 25 Stem Cell–Derived Islet Therapy for Type 1 Diabetes - p. 348 40. Index - p. 361
Despite extraordinary therapeutic advances since the discovery of insulin 100 years ago, diabetes prevalence continues to rise and significant challenges remain. Modern Diabetology: Basic Science and Clinical Practice provides a concise, one-stop reference that consolidates rapidly evolving research and clinical practice guidelines for today’s endocrinologists, general surgeons, internists, and primary care physicians.
1. Cover image - p. c 2. Title page - p. iii 3. Copyright - p. iv 4. Contributors - p. v 5. Reviewers - p. xi 6. Preface - p. xiii 7. Contents - p. xv 8. SECTION I Regulation of Gene Expression, Hormone Synthesis, and Hormone Secretion - p. 1 9. 1 Pancreatic Development in the Context of Diabetes - p. 2 10. 2 Glucagon: From Gene Regulation to Secretion - p. 17 11. 3 Insulin Production, Processing, and Secretion - p. 31 12. 4 Incretins: From Gene Expression to Secretion and Action of GLP-1 and GIP - p. 42 13. Section II Hormone Action - p. 65 14. 5 Glucagon Synthesis, Secretion, and Mechanisms of Action - p. 66 15. 6 Insulin Structure and Function - p. 78 16. 7 Common Mechanisms of Insulin Signaling, Action, and Resistance - p. 89 17. 8 Insulin Receptor Structure and Function - p. 108 18. 9 Insulin Action in Liver, Skeletal, Muscle, and Adipose Tissue: A Focus on Humans - p. 125 19. 10 Insulin Action in the Brain - p. 138 20. 11 Insulin Action in the Cardiovascular System - p. 152 21. 12 Metabolic Regulation by Adipokines, Hepatokines, and Myokines - p. 168 22. Section III Genetics of Diabetes - p. 179 23. 13 Genetics of Monogenic Forms of Diabetes - p. 180 24. 14 Genetics of Type 1 Diabetes - p. 190 25. 15 Genetics of Type 2 Diabetes - p. 209 26. Section IV Type 1 Diabetes - p. 223 27. 16 Spotlight on the Pathology of Type 1 Diabetes - p. 224 28. Section V Type 2 Diabetes - p. 239 29. 17 Heterogeneity of Type 2 Diabetes Mellitus - p. 240 30. 18 Cystic Fibrosis–Related Diabetes - p. 253 31. Section VI Complications of Diabetes - p. 265 32. 19 Intranuclear Beta Cell Nrf2 Expression in Type 2 Diabetes and the Potential Use of Glutathione Peroxidase Mimetics for Early Treatment - p. 266 33. 20 Diabetic Retinal Disease - p. 273 34. 21 Understanding Diabetic Neuropathy: From Pathophysiology to Therapeutic Targets - p. 288 35. Section VII Pharmacology and Drugs - p. 303 36. 22 SGLT2 Inhibitors and Slowing Kidney Disease Progression From Diabetes - p. 304 37. 23 Advanced Technology in Diabetes: Sensors and Pumps - p. 317 38. 24 Pancreas and Islet Cell Transplantation for Diabetes - p. 336 39. 25 Stem Cell–Derived Islet Therapy for Type 1 Diabetes - p. 348 40. Index - p. 361
