Standard therapy for high grade glioma is a topic that is evolving, timely, and relevant. Guest Editors Isaac Yang, MD and Seunggu Han, MD have assembled a group of experts to highlight the latest updates on various forms of management of high grade glioma. Some of the articles included in this issue focus on Extent of Resection for Glioblastoma; Role of adjuvant radiation therapy; Survival benefit of the Temozolomide protocol; Alternative chemotherapeutic agents; The role of avastin; Radiology; Pseuodprogression and Treatment effect; Pathology; Medical Management; Management of insular gliomas; Use of motor mapping; GBM treatment with clinical trials for surgical resection; Clinical trials with immunotherapy; Clinical trials for small molecule inhibitors; Future role of CED for GBM treatment; Application of a vault nanoparticle therapy for GBM therapy; Management of high grade gliomas in pediatric populations; Targeting Glioma Stem Like Cells with a focus on CD 133; and Potential Role for STAT3 inhibitors in glioblastoma.
1. Cover - p. 1 2. Contents - p. 2 3. Contributors - p. 3 4. Forthcoming Issues - p. 4 5. Preface - p. 5 6. Note to Readers - p. 6 7. Current Surgical Management of Insular Gliomas - p. 7 8. The Rise and Fall of “Biopsy and Radiate”: A History of Surgical Nihilism in Glioma Treatment - p. 12 9. The Use of Motor Mapping to Aid Resection of Eloquent Gliomas - p. 18 10. Characteristics and Treatment of Seizures in Patients with High-Grade Glioma: A Review - p. 28 11. Pathology: Commonly Monitored Glioblastoma Markers: EFGR, EGFRvIII, PTEN, and MGMT - p. 34 12. The Role of Adjuvant Radiation Therapy in the Management of High-Grade Gliomas - p. 41 13. Radiation Options for High-Grade Gliomas - p. 50 14. Radiology: Criteria for Determining Response to Treatment and Recurrence of High-Grade Gliomas - p. 57 15. Pseudoprogression and Treatment Effect - p. 64 16. The Role of BCNU Polymer Wafers (Gliadel) in the Treatment of Malignant Glioma - p. 73 17. Alternative Chemotherapeutic Agents: Nitrosoureas, Cisplatin, Irinotecan - p. 76 18. Temozolomide and Other Potential Agents for the Treatment of Glioblastoma Multiforme - p. 83 19. Superselective Intra-Arterial Cerebral Infusion of Novel Agents After Blood–Brain Disruption for the Treatment of Recurrent Glioblastoma Multiforme: A Technical Case Series - p. 95 20. The Role of Avastin in the Management of Recurrent Glioblastoma - p. 99 21. Management of Multifocal and Multicentric Gliomas - p. 107 22. Index - p. 113
Standard therapy for high grade glioma is a topic that is evolving, timely, and relevant. Guest Editors Isaac Yang, MD and Seunggu Han, MD have assembled a group of experts to highlight the latest updates on various forms of management of high grade glioma. Some of the articles included in this issue focus on Extent of Resection for Glioblastoma; Role of adjuvant radiation therapy; Survival benefit of the Temozolomide protocol; Alternative chemotherapeutic agents; The role of avastin; Radiology; Pseuodprogression and Treatment effect; Pathology; Medical Management; Management of insular gliomas; Use of motor mapping; GBM treatment with clinical trials for surgical resection; Clinical trials with immunotherapy; Clinical trials for small molecule inhibitors; Future role of CED for GBM treatment; Application of a vault nanoparticle therapy for GBM therapy; Management of high grade gliomas in pediatric populations; Targeting Glioma Stem Like Cells with a focus on CD 133; and Potential Role for STAT3 inhibitors in glioblastoma.
1. Cover - p. 1 2. Contents - p. 2 3. Contributors - p. 3 4. Forthcoming Issues - p. 4 5. Preface - p. 5 6. Note to Readers - p. 6 7. Current Surgical Management of Insular Gliomas - p. 7 8. The Rise and Fall of “Biopsy and Radiate”: A History of Surgical Nihilism in Glioma Treatment - p. 12 9. The Use of Motor Mapping to Aid Resection of Eloquent Gliomas - p. 18 10. Characteristics and Treatment of Seizures in Patients with High-Grade Glioma: A Review - p. 28 11. Pathology: Commonly Monitored Glioblastoma Markers: EFGR, EGFRvIII, PTEN, and MGMT - p. 34 12. The Role of Adjuvant Radiation Therapy in the Management of High-Grade Gliomas - p. 41 13. Radiation Options for High-Grade Gliomas - p. 50 14. Radiology: Criteria for Determining Response to Treatment and Recurrence of High-Grade Gliomas - p. 57 15. Pseudoprogression and Treatment Effect - p. 64 16. The Role of BCNU Polymer Wafers (Gliadel) in the Treatment of Malignant Glioma - p. 73 17. Alternative Chemotherapeutic Agents: Nitrosoureas, Cisplatin, Irinotecan - p. 76 18. Temozolomide and Other Potential Agents for the Treatment of Glioblastoma Multiforme - p. 83 19. Superselective Intra-Arterial Cerebral Infusion of Novel Agents After Blood–Brain Disruption for the Treatment of Recurrent Glioblastoma Multiforme: A Technical Case Series - p. 95 20. The Role of Avastin in the Management of Recurrent Glioblastoma - p. 99 21. Management of Multifocal and Multicentric Gliomas - p. 107 22. Index - p. 113
