Molecular Approach to Cancer Management discusses molecular mechanisms of cancer initiation, growth and secondary spread, emphasizing how this information can be used to devise new modes of treatment of cancer, especially in combatting secondary spread. The book addresses the basic concepts relating to cancer biology, the genetic determinants, and the signal transduction cascades associated with tumor growth, EMT, stem cell maintenance and propagation, and invasion and metastasis. The salient features of the signaling systems that are amenable to targeted manipulation are emphasized to facilitate research and development in the design of novel therapies and for the planning of new trials.
This book is the only unique volume with coverage of topics that target therapy. As such, it is a valuable source for cancer researchers, molecular oncologists and members of the biomedical field who are interested in knowing more about molecular approaches to cancer therapy.
1. Introduction - p. xxi 2. Chapter 1. Modulation of Growth Factor Signalling in Targeted Therapy: Role of the Epidermal Growth Factor Family and Their Receptors - p. 1 3. Chapter 2. The TGF-β Family Accessory Type III Receptor Function in Cancer Progression - p. 23 4. Chapter 3. Insulin-Like Growth Factor Signalling as a Target to Control Tumour Progression - p. 35 5. Chapter 4. Angiogenesis in Neoplasia and Anti-Angiogenesis Strategy in the Control of Tumour Growth and Metastasis - p. 43 6. Chapter 5. On the Trail of TRAIL (TNF-Related Apoptosis Inducing Ligand) in Tumour Growth and Angiogenesis - p. 49 7. Chapter 6. Hedgehog (Hh) Signalling in EMT (Epithelial Mesenchyme Transition), CSCs (Cancer Stem Cells) and Angiogenesis - p. 55 8. Chapter 7. Hippo Signalling in Cell Proliferation, Migration and Angiogenesis - p. 65 9. Chapter 8. Notch Signalling in Carcinogenesis - p. 81 10. Chapter 9. Canonical and Non-Canonical Activation of NF-κB in Tumorigenesis - p. 89 11. Chapter 10. Tumour Suppression and Inhibition of Angiogenesis by TXNIP (Thioredoxin Interacting Protein) - p. 101 12. Chapter 11. Cyclooxygenase-2 Inhibitors Suppress EMT, CSCs and Angiogenesis - p. 105 13. Chapter 12. Endogenous Inhibitors of Angiogenesis - p. 113 14. Chapter 13. Stem Cells in Cancer Therapy - p. 131 15. Chapter 14. Inhibitor of DNA-Binding Proteins in Angiogenesis - p. 139 16. Chapter 15. Small Molecule Inhibitors of Angiogenesis and Cell Proliferation - p. 143 17. Chapter 16. Suramin and Polysulphonated Naphthylureas as Angiogenesis Inhibitors - p. 149 18. Chapter 17. The Anti-Cancer Potential of Flavonoids - p. 151 19. Chapter 18. Selenoproteins in Cancer Control - p. 163 20. Chapter 19. Control of Tumour Growth and Angiogenesis by Thalidomide and Its Analogues - p. 167 21. Chapter 20. Metformin and Its Anti-Tumour Attributes - p. 175 22. Chapter 21. Statins in Cancer Biology - p. 179 23. Chapter 22. Are There Gains to be Made in Exploring Anthrax Lethal Toxin (LeTx) as a Tumour and an Angiogenesis Inhibitor? - p. 185 24. Chapter 23. The HMG (High Mobility Group) Proteins in Cancer Progression - p. 189 25. Chapter 24. MTAs in EMT Activation and Tumour and Metastasis Promotion - p. 201 26. Chapter 25. S100A4 Has Potential Benefits as a Therapeutic Target - p. 211 27. Chapter 26. Notable Approaches to Cancer Immunotherapy - p. 223 28. The Epilogue - p. 245 29. References - p. 257 30. Index - p. 313
Molecular Approach to Cancer Management discusses molecular mechanisms of cancer initiation, growth and secondary spread, emphasizing how this information can be used to devise new modes of treatment of cancer, especially in combatting secondary spread. The book addresses the basic concepts relating to cancer biology, the genetic determinants, and the signal transduction cascades associated with tumor growth, EMT, stem cell maintenance and propagation, and invasion and metastasis. The salient features of the signaling systems that are amenable to targeted manipulation are emphasized to facilitate research and development in the design of novel therapies and for the planning of new trials.
This book is the only unique volume with coverage of topics that target therapy. As such, it is a valuable source for cancer researchers, molecular oncologists and members of the biomedical field who are interested in knowing more about molecular approaches to cancer therapy.
1. Introduction - p. xxi 2. Chapter 1. Modulation of Growth Factor Signalling in Targeted Therapy: Role of the Epidermal Growth Factor Family and Their Receptors - p. 1 3. Chapter 2. The TGF-β Family Accessory Type III Receptor Function in Cancer Progression - p. 23 4. Chapter 3. Insulin-Like Growth Factor Signalling as a Target to Control Tumour Progression - p. 35 5. Chapter 4. Angiogenesis in Neoplasia and Anti-Angiogenesis Strategy in the Control of Tumour Growth and Metastasis - p. 43 6. Chapter 5. On the Trail of TRAIL (TNF-Related Apoptosis Inducing Ligand) in Tumour Growth and Angiogenesis - p. 49 7. Chapter 6. Hedgehog (Hh) Signalling in EMT (Epithelial Mesenchyme Transition), CSCs (Cancer Stem Cells) and Angiogenesis - p. 55 8. Chapter 7. Hippo Signalling in Cell Proliferation, Migration and Angiogenesis - p. 65 9. Chapter 8. Notch Signalling in Carcinogenesis - p. 81 10. Chapter 9. Canonical and Non-Canonical Activation of NF-κB in Tumorigenesis - p. 89 11. Chapter 10. Tumour Suppression and Inhibition of Angiogenesis by TXNIP (Thioredoxin Interacting Protein) - p. 101 12. Chapter 11. Cyclooxygenase-2 Inhibitors Suppress EMT, CSCs and Angiogenesis - p. 105 13. Chapter 12. Endogenous Inhibitors of Angiogenesis - p. 113 14. Chapter 13. Stem Cells in Cancer Therapy - p. 131 15. Chapter 14. Inhibitor of DNA-Binding Proteins in Angiogenesis - p. 139 16. Chapter 15. Small Molecule Inhibitors of Angiogenesis and Cell Proliferation - p. 143 17. Chapter 16. Suramin and Polysulphonated Naphthylureas as Angiogenesis Inhibitors - p. 149 18. Chapter 17. The Anti-Cancer Potential of Flavonoids - p. 151 19. Chapter 18. Selenoproteins in Cancer Control - p. 163 20. Chapter 19. Control of Tumour Growth and Angiogenesis by Thalidomide and Its Analogues - p. 167 21. Chapter 20. Metformin and Its Anti-Tumour Attributes - p. 175 22. Chapter 21. Statins in Cancer Biology - p. 179 23. Chapter 22. Are There Gains to be Made in Exploring Anthrax Lethal Toxin (LeTx) as a Tumour and an Angiogenesis Inhibitor? - p. 185 24. Chapter 23. The HMG (High Mobility Group) Proteins in Cancer Progression - p. 189 25. Chapter 24. MTAs in EMT Activation and Tumour and Metastasis Promotion - p. 201 26. Chapter 25. S100A4 Has Potential Benefits as a Therapeutic Target - p. 211 27. Chapter 26. Notable Approaches to Cancer Immunotherapy - p. 223 28. The Epilogue - p. 245 29. References - p. 257 30. Index - p. 313
