Molecular Biology of B Cells, Third Edition is a comprehensive reference to how B cells are generated, selected, activated, and engaged in antibody production. These developmental and stimulatory processes are described in molecular, immunological, and genetic terms to give a clear understanding of complex phenotypes. Molecular Biology of B Cells, Third Edition offers an integrated view of all aspects of B cells to produce a normal immune response as a constant, and the molecular basis of numerous diseases due to B cell abnormality. The new edition continues its success with updated research on B cell development and function, the use of therapeutic antibodies in cancer and infectious disease, therapeutic targeting of B cells for clinical application, new developments in lymphoma biology. With updated research and continued comprehensive coverage of all aspects of B cell biology, Molecular Biology of B Cells, Third Edition is the definitive resource, vital for researchers across molecular biology, immunology, and genetics.
1. 1: Introduction - p. 257 2. 2: Features and Properties of AID - p. 258 3. 3: Molecular Mechanism for DNA Cleavage and Recombination by AID - p. 265 4. 4: Regulation of DNA Cleavage, Repair and Recombination - p. 278 5. 5: The Regulation of AID Expression - p. 290 6. 6: Conclusions - p. 294 7. Chapter 14 Molecular Pathogenesis of B-Cell Lymphomas - p. 309 8. Chapter 15 Human Immunodeficiencies Caused by Inborn Errors of B-Cell Development or Function - p. 335 9. Chapter 16 Memory B Cells and Plasma Cells - p. 367 10. Chapter 17 Homoeostatic Versus Pathogenic Autoantibodies: Origin, Structure and Effector Functions - p. 387 11. Chapter 18 Anti-Tumour Necrosis Factor and New Paradigms for Therapies Using Antibodies - p. 413 12. Chapter 19 Therapeutic Targeting of B Cells and Plasma Cells with a Focus on Multiple Sclerosis and Other Autoimmune Conditions - p. 425 13. Chapter 20 IMGT Immunoglobulin Repertoire Analysis and Antibody Humanization - p. 437 14. Chapter 21 Mucosal Immunity to Bacteria and Immunoglobulin A Synthesis - p. 473 15. Chapter 22 B-Cell Metabolism - p. 487 16. Index - p. 517 17. Index - Continued - p. 525
Molecular Biology of B Cells, Third Edition is a comprehensive reference to how B cells are generated, selected, activated, and engaged in antibody production. These developmental and stimulatory processes are described in molecular, immunological, and genetic terms to give a clear understanding of complex phenotypes. Molecular Biology of B Cells, Third Edition offers an integrated view of all aspects of B cells to produce a normal immune response as a constant, and the molecular basis of numerous diseases due to B cell abnormality. The new edition continues its success with updated research on B cell development and function, the use of therapeutic antibodies in cancer and infectious disease, therapeutic targeting of B cells for clinical application, new developments in lymphoma biology. With updated research and continued comprehensive coverage of all aspects of B cell biology, Molecular Biology of B Cells, Third Edition is the definitive resource, vital for researchers across molecular biology, immunology, and genetics.
1. 1: Introduction - p. 257 2. 2: Features and Properties of AID - p. 258 3. 3: Molecular Mechanism for DNA Cleavage and Recombination by AID - p. 265 4. 4: Regulation of DNA Cleavage, Repair and Recombination - p. 278 5. 5: The Regulation of AID Expression - p. 290 6. 6: Conclusions - p. 294 7. Chapter 14 Molecular Pathogenesis of B-Cell Lymphomas - p. 309 8. Chapter 15 Human Immunodeficiencies Caused by Inborn Errors of B-Cell Development or Function - p. 335 9. Chapter 16 Memory B Cells and Plasma Cells - p. 367 10. Chapter 17 Homoeostatic Versus Pathogenic Autoantibodies: Origin, Structure and Effector Functions - p. 387 11. Chapter 18 Anti-Tumour Necrosis Factor and New Paradigms for Therapies Using Antibodies - p. 413 12. Chapter 19 Therapeutic Targeting of B Cells and Plasma Cells with a Focus on Multiple Sclerosis and Other Autoimmune Conditions - p. 425 13. Chapter 20 IMGT Immunoglobulin Repertoire Analysis and Antibody Humanization - p. 437 14. Chapter 21 Mucosal Immunity to Bacteria and Immunoglobulin A Synthesis - p. 473 15. Chapter 22 B-Cell Metabolism - p. 487 16. Index - p. 517 17. Index - Continued - p. 525
