In this issue of Clinics in Laboratory Medicine, guest editor Dr. Fei Dong brings his considerable expertise to the topic of Molecular Oncology Diagnostics. Top experts in the field review current practices in molecular oncology diagnostics, highlighting the rapid clinical adoption of next generation sequencing techniques. The articles address key laboratory considerations in the molecular testing of cancer specimens and the impact of advanced testing strategies on patient care.
Contains 15 practice-oriented topics including utility of single gene testing in cancer specimens; analytical principles of cancer next generation sequencing; principles and validation of bioinformatics pipelines for cancer next generation sequencing; panel sequencing for targeted therapy selection in solid tumors; and more.
Provides in-depth clinical reviews on molecular oncology diagnostics, offering actionable insights for clinical practice.
Presents the latest information on this timely, focused topic under the leadership of experienced editors in the field. Authors synthesize and distill the latest research and practice guidelines to create clinically significant, topic-based reviews.
1. Cover image - p. i 2. Title page - p. i 3. Table of Contents - p. i 4. Copyright - p. ii 5. Contributors - p. iii 6. Forthcoming Issues - p. xi 7. Preface - p. xiii 8. Panel Sequencing for Targeted Therapy Selection in Solid Tumors - p. 309 9. Molecular Diagnostic Testing for Hematopoietic Neoplasms: Linking Pathogenic Drivers to Personalized Diagnosis - p. 325 10. Special Considerations in the Molecular Diagnostics of Pediatric Neoplasms - p. 349 11. Specimen Considerations in Molecular Oncology Testing - p. 367 12. Utility of Single-Gene Testing in Cancer Specimens - p. 385 13. Analytical Principles of Cancer Next Generation Sequencing - p. 395 14. Principles and Validation of Bioinformatics Pipeline for Cancer Next-Generation Sequencing - p. 409 15. Best Practice for Clinical Somatic Variant Interpretation and Reporting - p. 423 16. Molecular Detection of Oncogenic Gene Rearrangements - p. 435 17. Copy Number Analysis in Cancer Diagnostic Testing - p. 451 18. Molecular Biomarkers of Response to Cancer Immunotherapy - p. 469 19. When Tissue Is the Issue: Expanding Cell-Free DNA “Liquid Biopsies” to Supernatants and Nonplasma Biofluids - p. 485 20. Germline Testing for the Evaluation of Hereditary Cancer Predisposition - p. 497
In this issue of Clinics in Laboratory Medicine, guest editor Dr. Fei Dong brings his considerable expertise to the topic of Molecular Oncology Diagnostics. Top experts in the field review current practices in molecular oncology diagnostics, highlighting the rapid clinical adoption of next generation sequencing techniques. The articles address key laboratory considerations in the molecular testing of cancer specimens and the impact of advanced testing strategies on patient care.
Contains 15 practice-oriented topics including utility of single gene testing in cancer specimens; analytical principles of cancer next generation sequencing; principles and validation of bioinformatics pipelines for cancer next generation sequencing; panel sequencing for targeted therapy selection in solid tumors; and more.
Provides in-depth clinical reviews on molecular oncology diagnostics, offering actionable insights for clinical practice.
Presents the latest information on this timely, focused topic under the leadership of experienced editors in the field. Authors synthesize and distill the latest research and practice guidelines to create clinically significant, topic-based reviews.
1. Cover image - p. i 2. Title page - p. i 3. Table of Contents - p. i 4. Copyright - p. ii 5. Contributors - p. iii 6. Forthcoming Issues - p. xi 7. Preface - p. xiii 8. Panel Sequencing for Targeted Therapy Selection in Solid Tumors - p. 309 9. Molecular Diagnostic Testing for Hematopoietic Neoplasms: Linking Pathogenic Drivers to Personalized Diagnosis - p. 325 10. Special Considerations in the Molecular Diagnostics of Pediatric Neoplasms - p. 349 11. Specimen Considerations in Molecular Oncology Testing - p. 367 12. Utility of Single-Gene Testing in Cancer Specimens - p. 385 13. Analytical Principles of Cancer Next Generation Sequencing - p. 395 14. Principles and Validation of Bioinformatics Pipeline for Cancer Next-Generation Sequencing - p. 409 15. Best Practice for Clinical Somatic Variant Interpretation and Reporting - p. 423 16. Molecular Detection of Oncogenic Gene Rearrangements - p. 435 17. Copy Number Analysis in Cancer Diagnostic Testing - p. 451 18. Molecular Biomarkers of Response to Cancer Immunotherapy - p. 469 19. When Tissue Is the Issue: Expanding Cell-Free DNA “Liquid Biopsies” to Supernatants and Nonplasma Biofluids - p. 485 20. Germline Testing for the Evaluation of Hereditary Cancer Predisposition - p. 497
