Dr. Richard Barohn and Dr. Mazen Dimachkie lead this publication on Motor Neuron Disease. Focus is on ALS, with inclusion of primary lateral sclerosis, primary muscular atrophy, leg amyotrophic diplegia, brachial amyotropic diplegia, and isolate bulbar ALS. Among the topics presented are. Patterns of weakness, classification of motor neuron disease & clinical diagnosis of sporadic ALS; Potential environmental factors in ALS; Neuropathology; Spinal muscular atrophy; Complementary and alternative therapies in ALS frontotemporal dysfunction and dementia in ALS; Symptoms management and end of life care; Research approaches to slowing progression of ALS; Familial ALS; Kennedy disease and more. Information in this issue presents: Description of the problem (Incidence, Prevalence, Severity, Natural history); 2. Review of pertinent data; Controversial areas discussing aspects such as areas of practice for which there are disagreements and why? What are the arguments and counter arguments and what data support them?; Conclusions using levels of clinical evidence that support or refute an intervention. Procedural steps are provided for diagnostic and treatment discussions along with clinical cases.
1. Cover image - p. Cover 2. Title page - p. Cover 3. Table of Contents - p. Cover 4. Copyright - p. Cover 5. Contributors - p. Cover 6. Forthcoming Issues - p. Cover 7. Preface. Motor Neuron Disease - p. Cover 8. Amyotrophic Lateral Sclerosis: A Historical Perspective - p. Cover 9. Patterns of Weakness, Classification of Motor Neuron Disease, and Clinical Diagnosis of Sporadic Amyotrophic Lateral Sclerosis - p. Cover 10. Primary Lateral Sclerosis - p. Cover 11. Progressive Muscular Atrophy - p. Cover 12. Amyotrophic Lateral Sclerosis Regional Variants (Brachial Amyotrophic Diplegia, Leg Amyotrophic Diplegia, and Isolated Bulbar Amyotrophic Lateral Sclerosis) - p. Cover 13. Frontotemporal Dysfunction and Dementia in Amyotrophic Lateral Sclerosis - p. Cover 14. Familial Amyotrophic Lateral Sclerosis - p. Cover 15. Spinal Muscular Atrophy - p. Cover 16. Spinal and Bulbar Muscular Atrophy - p. Cover 17. Neuropathology of Amyotrophic Lateral Sclerosis and Its Variants - p. Cover 18. Potential Environmental Factors in Amyotrophic Lateral Sclerosis - p. Cover 19. Symptom Management and End-of-Life Care in Amyotrophic Lateral Sclerosis - p. Cover 20. Complementary and Alternative Therapies in Amyotrophic Lateral Sclerosis - p. Cover 21. The Dilemma of the Clinical Trialist in Amyotrophic Lateral Sclerosis: The Hurdles to Finding a Cure - p. Cover 22. Index - p. Cover
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Dr. Richard Barohn and Dr. Mazen Dimachkie lead this publication on Motor Neuron Disease. Focus is on ALS, with inclusion of primary lateral sclerosis, primary muscular atrophy, leg amyotrophic diplegia, brachial amyotropic diplegia, and isolate bulbar ALS. Among the topics presented are. Patterns of weakness, classification of motor neuron disease & clinical diagnosis of sporadic ALS; Potential environmental factors in ALS; Neuropathology; Spinal muscular atrophy; Complementary and alternative therapies in ALS frontotemporal dysfunction and dementia in ALS; Symptoms management and end of life care; Research approaches to slowing progression of ALS; Familial ALS; Kennedy disease and more. Information in this issue presents: Description of the problem (Incidence, Prevalence, Severity, Natural history); 2. Review of pertinent data; Controversial areas discussing aspects such as areas of practice for which there are disagreements and why? What are the arguments and counter arguments and what data support them?; Conclusions using levels of clinical evidence that support or refute an intervention. Procedural steps are provided for diagnostic and treatment discussions along with clinical cases.
1. Cover image - p. Cover 2. Title page - p. Cover 3. Table of Contents - p. Cover 4. Copyright - p. Cover 5. Contributors - p. Cover 6. Forthcoming Issues - p. Cover 7. Preface. Motor Neuron Disease - p. Cover 8. Amyotrophic Lateral Sclerosis: A Historical Perspective - p. Cover 9. Patterns of Weakness, Classification of Motor Neuron Disease, and Clinical Diagnosis of Sporadic Amyotrophic Lateral Sclerosis - p. Cover 10. Primary Lateral Sclerosis - p. Cover 11. Progressive Muscular Atrophy - p. Cover 12. Amyotrophic Lateral Sclerosis Regional Variants (Brachial Amyotrophic Diplegia, Leg Amyotrophic Diplegia, and Isolated Bulbar Amyotrophic Lateral Sclerosis) - p. Cover 13. Frontotemporal Dysfunction and Dementia in Amyotrophic Lateral Sclerosis - p. Cover 14. Familial Amyotrophic Lateral Sclerosis - p. Cover 15. Spinal Muscular Atrophy - p. Cover 16. Spinal and Bulbar Muscular Atrophy - p. Cover 17. Neuropathology of Amyotrophic Lateral Sclerosis and Its Variants - p. Cover 18. Potential Environmental Factors in Amyotrophic Lateral Sclerosis - p. Cover 19. Symptom Management and End-of-Life Care in Amyotrophic Lateral Sclerosis - p. Cover 20. Complementary and Alternative Therapies in Amyotrophic Lateral Sclerosis - p. Cover 21. The Dilemma of the Clinical Trialist in Amyotrophic Lateral Sclerosis: The Hurdles to Finding a Cure - p. Cover 22. Index - p. Cover
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