Mucosal Vaccines: Innovation for Preventing Infectious Diseases discusses basic knowledge and discovery in the area of mucosal immunology and its related scientific fields. This completely updated, revised and authoritative treatise covers all aspects of mucosal vaccines, including their development, mechanisms of action, molecular/cellular aspects and practical applications. The book is organized in a unique format with basic, clinical and practical aspects described and discussed. The accumulated knowledge and new discoveries on the development of mucosal vaccines are logically introduced and discussed in an easy-to-understand format.
1. Part I: Introduction - p. xxiv 2. Chapter 1. Historical Perspectives on Mucosal Vaccines - p. 3 3. Part II: Principles of Mucosal Vaccine - p. 14 4. Chapter 2. Anatomical Uniqueness of the Mucosal Immune System (GALT, NALT, iBALT) for the Induction and Regulation of Mucosal Immunity and Tolerance - p. 21 5. Chapter 3. Mucosal Antigen Sampling Across the Villus Epithelium by Epithelial and Myeloid Cells - p. 55 6. Chapter 4. Protective Activities of Mucosal Antibodies - p. 71 7. Chapter 5. Mucosal Immunity for Inflammation: Regulation of Gut-Specific Lymphocyte Migration by Integrins - p. 85 8. Chapter 6. Innate Immunity at Mucosal Surfaces - p. 101 9. Chapter 7. Induction and Regulation of Mucosal Memory B Cell Responses - p. 117 10. Chapter 8. Induction and Regulation of Mucosal Memory T Cell Responses - p. 133 11. Chapter 9. Influence of Commensal Microbiota and Metabolite for Mucosal Immunity - p. 143 12. Part III: Mucosal Modulations for Induction of Effective Immunity - p. 159 13. Chapter 10. Innate Immunity-Based Mucosal Modulators and Adjuvants - p. 167 14. Chapter 11. Toxin-Based Modulators for Regulation of Mucosal Immune Responses - p. 185 15. Chapter 12. Influence of Dietary Components and Commensal Bacteria on the Control of Mucosal Immunity - p. 203 16. Chapter 13. Mast Cells for the Control of Mucosal Immunity - p. 213 17. Chapter 14. Innate Lymphoid Cells for the Control of Mucosal Immunity - p. 229 18. Chapter 15. Mucosal Regulatory System for Balanced Immunity in the Gut - p. 247 19. Chapter 16. Regulation of Mucosal Immunity in the Genital Tract: Balancing Reproduction and Protective Immunity - p. 255 20. Chapter 17. Mucosal Regulatory System for Balanced Ocular Immunity - p. 299 21. Chapter 18. Mucosal Regulatory System for the Balanced Immunity in the Middle Ear and Nasopharynx: Mucosal Immunity of Middle Ear and Nasopharynx - p. 313 22. Part IV: Current and New Approaches for Mucosal Vaccine Delivery - p. 320 23. Chapter 19. Current and New Approaches for Mucosal Vaccine Delivery - p. 325 24. Chapter 20. Plant-Based Mucosal Vaccine Delivery Systems - p. 357 25. Chapter 21. Plant-Based Mucosal Immunotherapy: Challenges for Commercialization - p. 371 26. Chapter 22. Attenuated Salmonella for Oral Immunization - p. 383 27. Chapter 23. Recombinant Bacillus Calmette-Guérin for Mucosal Immunity - p. 401 28. Chapter 24. Recombinant Adenovirus Vectors as Mucosal Vaccines - p. 419 29. Chapter 25. Mucosal Approaches for Systemic Immunity to Anthrax, Brucellosis, and Plague - p. 445 30. Chapter 26. Nanodelivery Vehicles for Mucosal Vaccines - p. 461 31. Chapter 27. Effectiveness of Sublingual Immunization: Innovation for Preventing Infectious Diseases - p. 477 32. Chapter 28. M Cell-Targeted Vaccines - p. 487 33. Part V: Mucosal Vaccines for Bacterial Diseases - p. 495 34. Chapter 29. Induction of Local and Systemic Immunity by Salmonella Typhi in Humans - p. 501 35. Chapter 30. Oral Shigella Vaccines - p. 515 36. Chapter 31. Cholera Immunity and Development and Use of Oral Cholera Vaccines for Disease Control - p. 537 37. Chapter 32. Oral Vaccines for Enterotoxigenic Escherichia coli - p. 563 38. Chapter 33. A Future for a Vaccine Against the Cancer-Inducing Bacterium Helicobacter pylori? - p. 579 39. Chapter 34. Mucosal Vaccines for Streptococcus pneumoniae - p. 597 40. Chapter 35. Development of a Mucosal TB Vaccine Using Human Parainfluenza Type 2 Virus - p. 611 41. Chapter 36. Sexually Transmitted Infections and the Urgent Need for Vaccines: A Review of Four Major Bacterial STI Pathogens - p. 625 42. Chapter 37. Mucosal Vaccines for Oral Disease - p. 649 43. Part VI: Mucosal Vaccines for Viral Diseases - p. 657 44. Chapter 38. Vaccination Against Respiratory Syncytial Virus - p. 665 45. Chapter 39. Nasal Influenza Vaccines - p. 677 46. Chapter 40. The Role of Innate Immunity in Regulating Rotavirus Replication, Pathogenesis, and Host Range Restriction and the Implications for Live Rotaviral Vaccine Development - p. 683 47. Chapter 41. Development of Oral Rotavirus and Norovirus Vaccines - p. 699 48. Chapter 42. Mucosal Vaccines Against HIV/SIV Infection - p. 713 49. Chapter 43. Mucosal Vaccines for Genital Herpes - p. 723 50. Chapter 44. Maternal Vaccination for Protection Against Maternal and Infant Bacterial and Viral Pathogens - p. 735 51. Part VII: New and Novel Approaches for Mucosal Vaccine Development - p. 745 52. Chapter 45. Systems Biological Approaches for Mucosal Vaccine Development - p. 753 53. Chapter 46. Harnessing γδ T Cells as Natural Immune Modulators - p. 773 54. Chapter 47. Mucosal Vaccines for Aged: Challenges and Struggles in Immunosenescence - p. 789 55. Part VIII: Can Mucosal Vaccines be Applied to Other Infectious and Noninfectious Diseases? - p. 803 56. Chapter 48. Mucosal Vaccine Development for Veterinary and Aquatic Diseases - p. 811 57. Chapter 49. Mucosal Vaccine for Malaria - p. 831 58. Chapter 50. Mucosal Vaccine for Parasitic Infections - p. 841 59. Chapter 51. Mucosal Vaccines for Allergy and Tolerance - p. 855 60. Chapter 52. Novel Strategies for Targeting the Control of Mucosal Inflammation - p. 869 61. Index - p. 881
Mucosal Vaccines: Innovation for Preventing Infectious Diseases discusses basic knowledge and discovery in the area of mucosal immunology and its related scientific fields. This completely updated, revised and authoritative treatise covers all aspects of mucosal vaccines, including their development, mechanisms of action, molecular/cellular aspects and practical applications. The book is organized in a unique format with basic, clinical and practical aspects described and discussed. The accumulated knowledge and new discoveries on the development of mucosal vaccines are logically introduced and discussed in an easy-to-understand format.
1. Part I: Introduction - p. xxiv 2. Chapter 1. Historical Perspectives on Mucosal Vaccines - p. 3 3. Part II: Principles of Mucosal Vaccine - p. 14 4. Chapter 2. Anatomical Uniqueness of the Mucosal Immune System (GALT, NALT, iBALT) for the Induction and Regulation of Mucosal Immunity and Tolerance - p. 21 5. Chapter 3. Mucosal Antigen Sampling Across the Villus Epithelium by Epithelial and Myeloid Cells - p. 55 6. Chapter 4. Protective Activities of Mucosal Antibodies - p. 71 7. Chapter 5. Mucosal Immunity for Inflammation: Regulation of Gut-Specific Lymphocyte Migration by Integrins - p. 85 8. Chapter 6. Innate Immunity at Mucosal Surfaces - p. 101 9. Chapter 7. Induction and Regulation of Mucosal Memory B Cell Responses - p. 117 10. Chapter 8. Induction and Regulation of Mucosal Memory T Cell Responses - p. 133 11. Chapter 9. Influence of Commensal Microbiota and Metabolite for Mucosal Immunity - p. 143 12. Part III: Mucosal Modulations for Induction of Effective Immunity - p. 159 13. Chapter 10. Innate Immunity-Based Mucosal Modulators and Adjuvants - p. 167 14. Chapter 11. Toxin-Based Modulators for Regulation of Mucosal Immune Responses - p. 185 15. Chapter 12. Influence of Dietary Components and Commensal Bacteria on the Control of Mucosal Immunity - p. 203 16. Chapter 13. Mast Cells for the Control of Mucosal Immunity - p. 213 17. Chapter 14. Innate Lymphoid Cells for the Control of Mucosal Immunity - p. 229 18. Chapter 15. Mucosal Regulatory System for Balanced Immunity in the Gut - p. 247 19. Chapter 16. Regulation of Mucosal Immunity in the Genital Tract: Balancing Reproduction and Protective Immunity - p. 255 20. Chapter 17. Mucosal Regulatory System for Balanced Ocular Immunity - p. 299 21. Chapter 18. Mucosal Regulatory System for the Balanced Immunity in the Middle Ear and Nasopharynx: Mucosal Immunity of Middle Ear and Nasopharynx - p. 313 22. Part IV: Current and New Approaches for Mucosal Vaccine Delivery - p. 320 23. Chapter 19. Current and New Approaches for Mucosal Vaccine Delivery - p. 325 24. Chapter 20. Plant-Based Mucosal Vaccine Delivery Systems - p. 357 25. Chapter 21. Plant-Based Mucosal Immunotherapy: Challenges for Commercialization - p. 371 26. Chapter 22. Attenuated Salmonella for Oral Immunization - p. 383 27. Chapter 23. Recombinant Bacillus Calmette-Guérin for Mucosal Immunity - p. 401 28. Chapter 24. Recombinant Adenovirus Vectors as Mucosal Vaccines - p. 419 29. Chapter 25. Mucosal Approaches for Systemic Immunity to Anthrax, Brucellosis, and Plague - p. 445 30. Chapter 26. Nanodelivery Vehicles for Mucosal Vaccines - p. 461 31. Chapter 27. Effectiveness of Sublingual Immunization: Innovation for Preventing Infectious Diseases - p. 477 32. Chapter 28. M Cell-Targeted Vaccines - p. 487 33. Part V: Mucosal Vaccines for Bacterial Diseases - p. 495 34. Chapter 29. Induction of Local and Systemic Immunity by Salmonella Typhi in Humans - p. 501 35. Chapter 30. Oral Shigella Vaccines - p. 515 36. Chapter 31. Cholera Immunity and Development and Use of Oral Cholera Vaccines for Disease Control - p. 537 37. Chapter 32. Oral Vaccines for Enterotoxigenic Escherichia coli - p. 563 38. Chapter 33. A Future for a Vaccine Against the Cancer-Inducing Bacterium Helicobacter pylori? - p. 579 39. Chapter 34. Mucosal Vaccines for Streptococcus pneumoniae - p. 597 40. Chapter 35. Development of a Mucosal TB Vaccine Using Human Parainfluenza Type 2 Virus - p. 611 41. Chapter 36. Sexually Transmitted Infections and the Urgent Need for Vaccines: A Review of Four Major Bacterial STI Pathogens - p. 625 42. Chapter 37. Mucosal Vaccines for Oral Disease - p. 649 43. Part VI: Mucosal Vaccines for Viral Diseases - p. 657 44. Chapter 38. Vaccination Against Respiratory Syncytial Virus - p. 665 45. Chapter 39. Nasal Influenza Vaccines - p. 677 46. Chapter 40. The Role of Innate Immunity in Regulating Rotavirus Replication, Pathogenesis, and Host Range Restriction and the Implications for Live Rotaviral Vaccine Development - p. 683 47. Chapter 41. Development of Oral Rotavirus and Norovirus Vaccines - p. 699 48. Chapter 42. Mucosal Vaccines Against HIV/SIV Infection - p. 713 49. Chapter 43. Mucosal Vaccines for Genital Herpes - p. 723 50. Chapter 44. Maternal Vaccination for Protection Against Maternal and Infant Bacterial and Viral Pathogens - p. 735 51. Part VII: New and Novel Approaches for Mucosal Vaccine Development - p. 745 52. Chapter 45. Systems Biological Approaches for Mucosal Vaccine Development - p. 753 53. Chapter 46. Harnessing γδ T Cells as Natural Immune Modulators - p. 773 54. Chapter 47. Mucosal Vaccines for Aged: Challenges and Struggles in Immunosenescence - p. 789 55. Part VIII: Can Mucosal Vaccines be Applied to Other Infectious and Noninfectious Diseases? - p. 803 56. Chapter 48. Mucosal Vaccine Development for Veterinary and Aquatic Diseases - p. 811 57. Chapter 49. Mucosal Vaccine for Malaria - p. 831 58. Chapter 50. Mucosal Vaccine for Parasitic Infections - p. 841 59. Chapter 51. Mucosal Vaccines for Allergy and Tolerance - p. 855 60. Chapter 52. Novel Strategies for Targeting the Control of Mucosal Inflammation - p. 869 61. Index - p. 881
