Multiscale Biomechanical Modeling of the Brain discusses the constitutive modeling of the brain at various length scales (nanoscale, microscale, mesoscale, macroscale and structural scale). In each scale, the book describes the state-of-the- experimental and computational tools used to quantify critical deformational information at each length scale. Then, at the structural scale, several user-based constitutive material models are presented, along with real-world boundary value problems. Lastly, design and optimization concepts are presented for use in occupant-centric design frameworks. This book is useful for both academia and industry applications that cover basic science aspects or applied research in head and brain protection.The multiscale approach to this topic is unique, and not found in other books. It includes meticulously selected materials that aim to connect the mechanistic analysis of the brain tissue at size scales ranging from subcellular to organ levels.
1. Chapter 2. Introduction to multiscale modeling of the human brain - p. iii 2. Chapter 3. Density functional theory and bridging to classical interatomic force fields - p. iii 3. Chapter 4. Modeling nanoscale cellular structures using molecular dynamics - p. iii 4. Chapter 5. Microscale mechanical modeling of brain neuron(s) and axon(s) - p. iii 5. Chapter 6. Mesoscale finite element modeling of brain structural heterogeneities and geometrical complexities - p. iii 6. Chapter 7. Modeling mesoscale anatomical structures in macroscale brain finite element models - p. iii 7. Chapter 8. A macroscale mechano-physiological internal state variable (MPISV) model for neuronal membrane damage with subscale microstructural effects - p. iii 8. Chapter 9. MRE-based modeling of head trauma - p. iii 9. Chapter 10. Robust concept exploration of driver’s side vehicular impacts for human-centric crashworthiness - p. iii 10. Chapter 11. Development of a coupled physical–computational methodology for the investigation of infant head injury - p. iii 11. Chapter 12. Experimental data for validating the structural response of computational brain models - p. iii 12. Chapter 13. A review of fluid flow in and around the brain, modeling, and abnormalities - p. iii 13. Chapter 14. Resonant frequencies of a human brain, skull, and head - p. iii 14. Chapter 15. State-of-the-art of multiscale modeling of mechanical impacts to the human brain - p. iii 15. Index - p. iii
Multiscale Biomechanical Modeling of the Brain discusses the constitutive modeling of the brain at various length scales (nanoscale, microscale, mesoscale, macroscale and structural scale). In each scale, the book describes the state-of-the- experimental and computational tools used to quantify critical deformational information at each length scale. Then, at the structural scale, several user-based constitutive material models are presented, along with real-world boundary value problems. Lastly, design and optimization concepts are presented for use in occupant-centric design frameworks. This book is useful for both academia and industry applications that cover basic science aspects or applied research in head and brain protection.The multiscale approach to this topic is unique, and not found in other books. It includes meticulously selected materials that aim to connect the mechanistic analysis of the brain tissue at size scales ranging from subcellular to organ levels.
1. Chapter 2. Introduction to multiscale modeling of the human brain - p. iii 2. Chapter 3. Density functional theory and bridging to classical interatomic force fields - p. iii 3. Chapter 4. Modeling nanoscale cellular structures using molecular dynamics - p. iii 4. Chapter 5. Microscale mechanical modeling of brain neuron(s) and axon(s) - p. iii 5. Chapter 6. Mesoscale finite element modeling of brain structural heterogeneities and geometrical complexities - p. iii 6. Chapter 7. Modeling mesoscale anatomical structures in macroscale brain finite element models - p. iii 7. Chapter 8. A macroscale mechano-physiological internal state variable (MPISV) model for neuronal membrane damage with subscale microstructural effects - p. iii 8. Chapter 9. MRE-based modeling of head trauma - p. iii 9. Chapter 10. Robust concept exploration of driver’s side vehicular impacts for human-centric crashworthiness - p. iii 10. Chapter 11. Development of a coupled physical–computational methodology for the investigation of infant head injury - p. iii 11. Chapter 12. Experimental data for validating the structural response of computational brain models - p. iii 12. Chapter 13. A review of fluid flow in and around the brain, modeling, and abnormalities - p. iii 13. Chapter 14. Resonant frequencies of a human brain, skull, and head - p. iii 14. Chapter 15. State-of-the-art of multiscale modeling of mechanical impacts to the human brain - p. iii 15. Index - p. iii
