Known for its clear readability, thorough coverage, and expert authorship, Murray & Nadel’s Textbook of Respiratory Medicine has long been the gold standard text in the fast-changing field of pulmonary medicine. The new 7th Edition brings you fully up to date with newly expanded content, numerous new chapters, a new editorial team, and extensive updates throughout. It covers the entire spectrum of pulmonology in one authoritative point-of-care reference, making it an ideal resource for pulmonary physicians, fellows, and other pulmonary practitioners.
1. Instructions for online access - p. i 2. Cover image - p. i 3. Title page - p. ii 4. Disclaimer - p. ii 5. Table of Contents - p. iii 6. Copyright - p. iv 7. Dedication - p. v 8. Dedication - p. vi 9. Contributors - p. viii 10. Preface to the Seventh Edition - p. xxxii 11. VOLUME 1 - p. xxxii 12. Part 1 Scientific Principles of Respiratory Medicine - p. 1 13. Section A. Anatomy and Development of the Respiratory Tract - p. 2 14. 1: Anatomy - p. 3 15. 2: Lung Growth and Development - p. 24 16. 3: Alveolar Compartment - p. 33 17. 4: Airway Biology - p. 49 18. 5: Lung Mesenchyme - p. 66 19. 6: Vascular Biology - p. 76 20. 7: Lymphatic Biology - p. 88 21. 8: Regeneration and Repair - p. 96 22. 9: Genetics of Lung Disease - p. 106 23. Section B. Respiratory Physiology - p. 115.e2 24. 10: Ventilation, Blood Flow, and Gas Exchange - p. 116 25. 11: Respiratory System Mechanics and Energetics - p. 140 26. 12: Acid-Base Balance - p. 154 27. 13: Aerosols and Drug Delivery - p. 168 28. 14: Pleural Physiology and Pathophysiology - p. 180 29. Section C. Defense Mechanisms and Immunology - p. 190.e2 30. 15: Innate Immunity - p. 191 31. 16: Adaptive Immunity - p. 208 32. 17: Microbiome - p. 228 33. Part 2 Diagnosis and Evaluation of Respiratory Disease - p. 239 34. Section D. Diagnosis - p. 240 35. 18: History and Physical Examination - p. 241 36. 19: Microbiologic Diagnosis of Lung Infection - p. 254 37. 20: Thoracic Radiology - p. 272 38. 21: Thoracic Radiology - p. 300 39. 22: Pathology - p. 312 40. 23: Ultrasonography - p. 330 41. 24: Ultrasonography - p. 343 42. 25: Positron Emission Tomography - p. 355 43. 26: Diagnostic Bronchoscopy - p. 368 44. 27: Diagnostic Bronchoscopy - p. 376 45. 28: Therapeutic Bronchoscopy - p. 388 46. 29: Thoracoscopy - p. 399 47. 30: Thoracic Surgery - p. 412 48. Section E. Evaluation - p. 423.e2 49. 31: Pulmonary Function Testing - p. 424 50. 32: Pulmonary Function Testing - p. 439 51. 33: Exercise Testing - p. 454 52. 34: Preoperative Evaluation - p. 472 53. 35: Evaluation of Respiratory Impairment and Disability - p. 480 54. Part 3 Clinical Respiratory Medicine - p. 495 55. Section F. Evaluation of Common Presentations of Respiratory Disease - p. 496 56. 36: Dyspnea - p. 497 57. 37: Cough - p. 508 58. 38: Chest Pain - p. 521 59. 39: Wheezing And Stridor - p. 532 60. 40: Hemoptysis - p. 539 61. 41: Pulmonary Nodule - p. 548 62. 42: Positive Screening Test for Tuberculosis - p. 559 63. 43: Aspiration - p. 569 64. 44: Hypoxemia - p. 578 65. 45: Hypercapnia - p. 590 66. Section G. Infectious Diseases of the Lungs - p. 599.e2 67. 46: Community-Acquired Pneumonia - p. 600 68. 46a: COVID-19 - p. 620 69. 47: Influenza - p. 634 70. 48: Hospital-Acquired Pneumonia - p. 646 71. 49: Ventilator-Associated Pneumonia - p. 657 72. 50: Lung Abscess - p. 668 73. 51: Tuberculosis - p. 674 74. 52: Tuberculosis - p. 684 75. 53: Tuberculosis - p. 692 76. 54: Tuberculosis - p. 708 77. 55: Nontuberculous Mycobacterial Infections - p. 725 78. 56: Fungal Infections - p. 748 79. 57: Fungal Infections - p. 763 80. 58: Parasitic Infections - p. 781 81. 59: Outbreaks, Pandemics, and Bioterrorism - p. 797 82. Section H. Obstructive Diseases - p. 806.e1 83. 60: Asthma - p. 807 84. 61: Asthma and Obesity - p. 825 85. 62: Asthma - p. 831 86. 63: COPD - p. 850 87. 64: COPD - p. 870 88. 65: Smoking Hazards - p. 890 89. 66: Smoking Cessation - p. 900 90. 67: Cystic Fibrosis - p. 910 91. 68: Cystic Fibrosis - p. 919 92. 69: Bronchiectasis - p. 941 93. 70: Upper Airway Disorders - p. 961 94. 71: Large Airway Disorders - p. 982 95. 72: Bronchiolitis - p. 994 96. VOLUME 2 - p. 1004.e4 97. Section I. Neoplasms of the Lung - p. 1004.e4 98. 73: Lung Cancer: Molecular Biology and Targets - p. 1005 99. 74: Lung Cancer: Epidemiology - p. 1018 100. 75: Lung Cancer: Screening - p. 1029 101. 76: Lung Cancer: Diagnosis and Staging - p. 1039 102. 77: Lung Cancer: Treatment - p. 1052 103. 78: Rare Primary Lung Tumors - p. 1066 104. 79: Metastatic Malignant Tumors - p. 1080 105. 80: Benign Lung Tumors - p. 1091 106. Section J. Disorders of the Pulmonary Circulation - p. 1100.e3 107. 81: Pulmonary Thromboembolism: Presentation and Diagnosis - p. 1101 108. 82: Pulmonary Thromboembolism: Prophylaxis and Treatment - p. 1123 109. 83: Pulmonary Hypertension: General Approach - p. 1141 110. 84: Pulmonary Arterial Hypertension: Group 1 - p. 1159 111. 85: Pulmonary Hypertension Due to Lung Disease: Group 3 - p. 1171 112. 86: Pulmonary Hypertension Due to Chronic Thromboembolic Disease: Group 4 - p. 1185 113. 87: Pulmonary Vasculitis - p. 1194 114. 88: Pulmonary Vascular Anomalies - p. 1212 115. Section K. Infiltrative and Interstitial Lung Diseases - p. 1220.e2 116. 89: Idiopathic Pulmonary Fibrosis - p. 1221 117. 90: Nonspecific Interstitial Pneumonitis and Other Idiopathic Interstitial Pneumonias - p. 1235 118. 91: Hypersensitivity Pneumonitis - p. 1248 119. 92: Connective Tissue Diseases - p. 1262 120. 93: Sarcoidosis - p. 1284 121. 94: Diffuse Alveolar Hemorrhage - p. 1301 122. 95: Pulmonary Langerhans Cell Histiocytosis and Other Rare Diffuse Infiltrative Lung Diseases - p. 1314 123. 96: Eosinophilic Lung Diseases - p. 1322 124. 97: Lymphangioleiomyomatosis - p. 1343 125. 98: Pulmonary Alveolar Proteinosis Syndrome - p. 1363 126. 99: Drug-Induced Pulmonary Disease - p. 1378 127. Section L. Environmental and Occupational Hazards - p. 1394.e3 128. 100: Asthma in the Workplace - p. 1395 129. 101: Pneumoconioses - p. 1409 130. 102: Indoor and Outdoor Air Pollution - p. 1423 131. 103: Acute Responses to Toxic Exposures - p. 1435 132. 104: Trauma and Blast Injuries - p. 1447 133. 105: High Altitude - p. 1460 134. 106: Air Travel - p. 1475 135. 107: Diving Medicine - p. 1486 136. Section M. Disorders of the Pleura - p. 1497.e7 137. 108: Pleural Effusion - p. 1498 138. 109: Pleural Infections - p. 1524 139. 110: Pneumothorax - p. 1539 140. 111: Chylothorax - p. 1551 141. 112: Pleural Fibrosis and Unexpandable Lung - p. 1560 142. 113: Hemothorax - p. 1570 143. 114: Pleural Malignancy - p. 1575 144. Section N. Disorders of the Mediastinum - p. 1589.e10 145. 115: Mediastinal Tumors and Cysts - p. 1590 146. 116: Mediastinitis and Fibrosing Mediastinitis - p. 1605 147. Section O. Disorders of Sleep and Control of Breathing - p. 1617.e3 148. 117: Control of Breathing and Upper Airways During Sleep - p. 1618 149. 118: Consequences of Sleep Disruption - p. 1633 150. 119: Sleep-Disordered Breathing: A General Approach - p. 1643 151. 120: Obstructive Sleep Apnea - p. 1654 152. 121: Central Sleep Apnea - p. 1670 153. 122: Sleep-Disordered Breathing: Treatment - p. 1687 154. Section P. Respiratory Manifestations of Extrapulmonary Disorders - p. 1702.e4 155. 123: Pulmonary Complications of HIV Infection - p. 1703 156. 124: Pulmonary Complications of Primary Immunodeficiencies - p. 1728 157. 125: Pulmonary Complications of Stem Cell and Solid Organ Transplantation - p. 1745 158. 126: Pulmonary Complications of Abdominal Diseases - p. 1758 159. 127: Pulmonary Complications of Hematologic Diseases - p. 1773 160. 128: Pulmonary Complications of Endocrine Diseases - p. 1788 161. 129: The Lungs in Obstetric and Gynecologic Diseases - p. 1799 162. 130: The Respiratory System and Neuromuscular Diseases - p. 1812 163. 131: The Respiratory System and Chest Wall Diseases - p. 1829 164. Section Q. Management of Respiratory Failure - p. 1842.e6 165. 132: Acute Ventilatory Failure - p. 1843 166. 133: Pulmonary Edema - p. 1860 167. 134: Acute Respiratory Distress Syndrome - p. 1880 168. 135: Mechanical Ventilation - p. 1903 169. 136: Noninvasive Support of Ventilation - p. 1918 170. 137: Noninvasive Support of Oxygenation - p. 1931 171. 138: Extracorporeal Support of Gas Exchange - p. 1939 172. 139: Pulmonary Rehabilitation - p. 1951 173. 140: Lung Transplantation - p. 1964 174. 141: End-of-Life Care in Respiratory Failure - p. 1980 175. Appendix - p. A-1 176. Index - p. I-1
Known for its clear readability, thorough coverage, and expert authorship, Murray & Nadel’s Textbook of Respiratory Medicine has long been the gold standard text in the fast-changing field of pulmonary medicine. The new 7th Edition brings you fully up to date with newly expanded content, numerous new chapters, a new editorial team, and extensive updates throughout. It covers the entire spectrum of pulmonology in one authoritative point-of-care reference, making it an ideal resource for pulmonary physicians, fellows, and other pulmonary practitioners.
1. Instructions for online access - p. i 2. Cover image - p. i 3. Title page - p. ii 4. Disclaimer - p. ii 5. Table of Contents - p. iii 6. Copyright - p. iv 7. Dedication - p. v 8. Dedication - p. vi 9. Contributors - p. viii 10. Preface to the Seventh Edition - p. xxxii 11. VOLUME 1 - p. xxxii 12. Part 1 Scientific Principles of Respiratory Medicine - p. 1 13. Section A. Anatomy and Development of the Respiratory Tract - p. 2 14. 1: Anatomy - p. 3 15. 2: Lung Growth and Development - p. 24 16. 3: Alveolar Compartment - p. 33 17. 4: Airway Biology - p. 49 18. 5: Lung Mesenchyme - p. 66 19. 6: Vascular Biology - p. 76 20. 7: Lymphatic Biology - p. 88 21. 8: Regeneration and Repair - p. 96 22. 9: Genetics of Lung Disease - p. 106 23. Section B. Respiratory Physiology - p. 115.e2 24. 10: Ventilation, Blood Flow, and Gas Exchange - p. 116 25. 11: Respiratory System Mechanics and Energetics - p. 140 26. 12: Acid-Base Balance - p. 154 27. 13: Aerosols and Drug Delivery - p. 168 28. 14: Pleural Physiology and Pathophysiology - p. 180 29. Section C. Defense Mechanisms and Immunology - p. 190.e2 30. 15: Innate Immunity - p. 191 31. 16: Adaptive Immunity - p. 208 32. 17: Microbiome - p. 228 33. Part 2 Diagnosis and Evaluation of Respiratory Disease - p. 239 34. Section D. Diagnosis - p. 240 35. 18: History and Physical Examination - p. 241 36. 19: Microbiologic Diagnosis of Lung Infection - p. 254 37. 20: Thoracic Radiology - p. 272 38. 21: Thoracic Radiology - p. 300 39. 22: Pathology - p. 312 40. 23: Ultrasonography - p. 330 41. 24: Ultrasonography - p. 343 42. 25: Positron Emission Tomography - p. 355 43. 26: Diagnostic Bronchoscopy - p. 368 44. 27: Diagnostic Bronchoscopy - p. 376 45. 28: Therapeutic Bronchoscopy - p. 388 46. 29: Thoracoscopy - p. 399 47. 30: Thoracic Surgery - p. 412 48. Section E. Evaluation - p. 423.e2 49. 31: Pulmonary Function Testing - p. 424 50. 32: Pulmonary Function Testing - p. 439 51. 33: Exercise Testing - p. 454 52. 34: Preoperative Evaluation - p. 472 53. 35: Evaluation of Respiratory Impairment and Disability - p. 480 54. Part 3 Clinical Respiratory Medicine - p. 495 55. Section F. Evaluation of Common Presentations of Respiratory Disease - p. 496 56. 36: Dyspnea - p. 497 57. 37: Cough - p. 508 58. 38: Chest Pain - p. 521 59. 39: Wheezing And Stridor - p. 532 60. 40: Hemoptysis - p. 539 61. 41: Pulmonary Nodule - p. 548 62. 42: Positive Screening Test for Tuberculosis - p. 559 63. 43: Aspiration - p. 569 64. 44: Hypoxemia - p. 578 65. 45: Hypercapnia - p. 590 66. Section G. Infectious Diseases of the Lungs - p. 599.e2 67. 46: Community-Acquired Pneumonia - p. 600 68. 46a: COVID-19 - p. 620 69. 47: Influenza - p. 634 70. 48: Hospital-Acquired Pneumonia - p. 646 71. 49: Ventilator-Associated Pneumonia - p. 657 72. 50: Lung Abscess - p. 668 73. 51: Tuberculosis - p. 674 74. 52: Tuberculosis - p. 684 75. 53: Tuberculosis - p. 692 76. 54: Tuberculosis - p. 708 77. 55: Nontuberculous Mycobacterial Infections - p. 725 78. 56: Fungal Infections - p. 748 79. 57: Fungal Infections - p. 763 80. 58: Parasitic Infections - p. 781 81. 59: Outbreaks, Pandemics, and Bioterrorism - p. 797 82. Section H. Obstructive Diseases - p. 806.e1 83. 60: Asthma - p. 807 84. 61: Asthma and Obesity - p. 825 85. 62: Asthma - p. 831 86. 63: COPD - p. 850 87. 64: COPD - p. 870 88. 65: Smoking Hazards - p. 890 89. 66: Smoking Cessation - p. 900 90. 67: Cystic Fibrosis - p. 910 91. 68: Cystic Fibrosis - p. 919 92. 69: Bronchiectasis - p. 941 93. 70: Upper Airway Disorders - p. 961 94. 71: Large Airway Disorders - p. 982 95. 72: Bronchiolitis - p. 994 96. VOLUME 2 - p. 1004.e4 97. Section I. Neoplasms of the Lung - p. 1004.e4 98. 73: Lung Cancer: Molecular Biology and Targets - p. 1005 99. 74: Lung Cancer: Epidemiology - p. 1018 100. 75: Lung Cancer: Screening - p. 1029 101. 76: Lung Cancer: Diagnosis and Staging - p. 1039 102. 77: Lung Cancer: Treatment - p. 1052 103. 78: Rare Primary Lung Tumors - p. 1066 104. 79: Metastatic Malignant Tumors - p. 1080 105. 80: Benign Lung Tumors - p. 1091 106. Section J. Disorders of the Pulmonary Circulation - p. 1100.e3 107. 81: Pulmonary Thromboembolism: Presentation and Diagnosis - p. 1101 108. 82: Pulmonary Thromboembolism: Prophylaxis and Treatment - p. 1123 109. 83: Pulmonary Hypertension: General Approach - p. 1141 110. 84: Pulmonary Arterial Hypertension: Group 1 - p. 1159 111. 85: Pulmonary Hypertension Due to Lung Disease: Group 3 - p. 1171 112. 86: Pulmonary Hypertension Due to Chronic Thromboembolic Disease: Group 4 - p. 1185 113. 87: Pulmonary Vasculitis - p. 1194 114. 88: Pulmonary Vascular Anomalies - p. 1212 115. Section K. Infiltrative and Interstitial Lung Diseases - p. 1220.e2 116. 89: Idiopathic Pulmonary Fibrosis - p. 1221 117. 90: Nonspecific Interstitial Pneumonitis and Other Idiopathic Interstitial Pneumonias - p. 1235 118. 91: Hypersensitivity Pneumonitis - p. 1248 119. 92: Connective Tissue Diseases - p. 1262 120. 93: Sarcoidosis - p. 1284 121. 94: Diffuse Alveolar Hemorrhage - p. 1301 122. 95: Pulmonary Langerhans Cell Histiocytosis and Other Rare Diffuse Infiltrative Lung Diseases - p. 1314 123. 96: Eosinophilic Lung Diseases - p. 1322 124. 97: Lymphangioleiomyomatosis - p. 1343 125. 98: Pulmonary Alveolar Proteinosis Syndrome - p. 1363 126. 99: Drug-Induced Pulmonary Disease - p. 1378 127. Section L. Environmental and Occupational Hazards - p. 1394.e3 128. 100: Asthma in the Workplace - p. 1395 129. 101: Pneumoconioses - p. 1409 130. 102: Indoor and Outdoor Air Pollution - p. 1423 131. 103: Acute Responses to Toxic Exposures - p. 1435 132. 104: Trauma and Blast Injuries - p. 1447 133. 105: High Altitude - p. 1460 134. 106: Air Travel - p. 1475 135. 107: Diving Medicine - p. 1486 136. Section M. Disorders of the Pleura - p. 1497.e7 137. 108: Pleural Effusion - p. 1498 138. 109: Pleural Infections - p. 1524 139. 110: Pneumothorax - p. 1539 140. 111: Chylothorax - p. 1551 141. 112: Pleural Fibrosis and Unexpandable Lung - p. 1560 142. 113: Hemothorax - p. 1570 143. 114: Pleural Malignancy - p. 1575 144. Section N. Disorders of the Mediastinum - p. 1589.e10 145. 115: Mediastinal Tumors and Cysts - p. 1590 146. 116: Mediastinitis and Fibrosing Mediastinitis - p. 1605 147. Section O. Disorders of Sleep and Control of Breathing - p. 1617.e3 148. 117: Control of Breathing and Upper Airways During Sleep - p. 1618 149. 118: Consequences of Sleep Disruption - p. 1633 150. 119: Sleep-Disordered Breathing: A General Approach - p. 1643 151. 120: Obstructive Sleep Apnea - p. 1654 152. 121: Central Sleep Apnea - p. 1670 153. 122: Sleep-Disordered Breathing: Treatment - p. 1687 154. Section P. Respiratory Manifestations of Extrapulmonary Disorders - p. 1702.e4 155. 123: Pulmonary Complications of HIV Infection - p. 1703 156. 124: Pulmonary Complications of Primary Immunodeficiencies - p. 1728 157. 125: Pulmonary Complications of Stem Cell and Solid Organ Transplantation - p. 1745 158. 126: Pulmonary Complications of Abdominal Diseases - p. 1758 159. 127: Pulmonary Complications of Hematologic Diseases - p. 1773 160. 128: Pulmonary Complications of Endocrine Diseases - p. 1788 161. 129: The Lungs in Obstetric and Gynecologic Diseases - p. 1799 162. 130: The Respiratory System and Neuromuscular Diseases - p. 1812 163. 131: The Respiratory System and Chest Wall Diseases - p. 1829 164. Section Q. Management of Respiratory Failure - p. 1842.e6 165. 132: Acute Ventilatory Failure - p. 1843 166. 133: Pulmonary Edema - p. 1860 167. 134: Acute Respiratory Distress Syndrome - p. 1880 168. 135: Mechanical Ventilation - p. 1903 169. 136: Noninvasive Support of Ventilation - p. 1918 170. 137: Noninvasive Support of Oxygenation - p. 1931 171. 138: Extracorporeal Support of Gas Exchange - p. 1939 172. 139: Pulmonary Rehabilitation - p. 1951 173. 140: Lung Transplantation - p. 1964 174. 141: End-of-Life Care in Respiratory Failure - p. 1980 175. Appendix - p. A-1 176. Index - p. I-1
