Na Channels from Phyla to Function, the latest volume in the Current Topics in Membranes series, is targeted toward scientists and researchers in biochemistry and molecular and cellular biology, providing the necessary membrane research to assist them in discovering the current state of a particular field and in learning where that field is heading. This volume offers an up-to-date presentation of the current knowledge in the field of Na Channels.
1. 1. Introduction - p. 354 2. 2. Regulation of Nav Channels by the Physiochemical Properties of the Bilayer - p. 357 3. 3. Fatty Acids - p. 360 4. 4. Glycerophospholipids - p. 370 5. 5. Sterols - p. 376 6. 6. Sphingolipids - p. 379 7. 7. Cannabinoids - p. 385 8. 8. Conclusions - p. 389 9. Chapter Thirteen. Mechanism of Inactivation in Voltage-Gated Na+ Channels - p. 409 10. 1. Molecular Architecture of Voltage-Gated Na+ Channels - p. 410 11. 2. The Kinetic States of Voltage-Gated Na+ Channels - p. 411 12. 3. Fast Inactivation - p. 412 13. 4. Long-Term Inactivation - p. 418 14. 5. Slow Inactivation - p. 418 15. 6. Summary and Outlook - p. 436 16. Chapter Fourteen. Current–Voltage Relationship for Late Na+ Current in Adult Rat Ventricular Myocytes - p. 451 17. Chapter Fifteen. Physiology and Pathophysiology of Sodium Channel Inactivation - p. 479 18. Section 5: Sodium Channels Under Stress and in Disease - p. 509 19. Chapter Sixteen. Cardiac Sodium Channel Mutations: Why so Many Phenotypes? - p. 513 20. 1. Introduction - p. 514 21. 2. The Cardiac Nav1.5 - p. 517 22. 3. Phenotypic Variability of Cardiac Nav1.5 Mutations - p. 518 23. 4. Sources of Phenotypic Variability - p. 527 24. 5. Summary - p. 545 25. 6. Disclosures - p. 546 26. Chapter Seventeen. Nav Channels in Damaged Membranes - p. 561 27. Chapter Eighteen. Unusual Voltage-Gated Sodium Currents as Targets for Pain - p. 599 28. 1. Overview - p. 600 29. 2. Sodium Channels in Peripheral Sensory Neurons - p. 602 30. 3. Inactivation and Resurgent Current Contribution to Excitability of Sensory Neurons - p. 608 31. 4. Classic Sodium Currents Role in Pain - p. 612 32. 5. Atypical Sodium Currents and Pain - p. 615 33. 6. Therapeutic Strategies - p. 622 34. Index - p. 639
Na Channels from Phyla to Function, the latest volume in the Current Topics in Membranes series, is targeted toward scientists and researchers in biochemistry and molecular and cellular biology, providing the necessary membrane research to assist them in discovering the current state of a particular field and in learning where that field is heading. This volume offers an up-to-date presentation of the current knowledge in the field of Na Channels.
1. 1. Introduction - p. 354 2. 2. Regulation of Nav Channels by the Physiochemical Properties of the Bilayer - p. 357 3. 3. Fatty Acids - p. 360 4. 4. Glycerophospholipids - p. 370 5. 5. Sterols - p. 376 6. 6. Sphingolipids - p. 379 7. 7. Cannabinoids - p. 385 8. 8. Conclusions - p. 389 9. Chapter Thirteen. Mechanism of Inactivation in Voltage-Gated Na+ Channels - p. 409 10. 1. Molecular Architecture of Voltage-Gated Na+ Channels - p. 410 11. 2. The Kinetic States of Voltage-Gated Na+ Channels - p. 411 12. 3. Fast Inactivation - p. 412 13. 4. Long-Term Inactivation - p. 418 14. 5. Slow Inactivation - p. 418 15. 6. Summary and Outlook - p. 436 16. Chapter Fourteen. Current–Voltage Relationship for Late Na+ Current in Adult Rat Ventricular Myocytes - p. 451 17. Chapter Fifteen. Physiology and Pathophysiology of Sodium Channel Inactivation - p. 479 18. Section 5: Sodium Channels Under Stress and in Disease - p. 509 19. Chapter Sixteen. Cardiac Sodium Channel Mutations: Why so Many Phenotypes? - p. 513 20. 1. Introduction - p. 514 21. 2. The Cardiac Nav1.5 - p. 517 22. 3. Phenotypic Variability of Cardiac Nav1.5 Mutations - p. 518 23. 4. Sources of Phenotypic Variability - p. 527 24. 5. Summary - p. 545 25. 6. Disclosures - p. 546 26. Chapter Seventeen. Nav Channels in Damaged Membranes - p. 561 27. Chapter Eighteen. Unusual Voltage-Gated Sodium Currents as Targets for Pain - p. 599 28. 1. Overview - p. 600 29. 2. Sodium Channels in Peripheral Sensory Neurons - p. 602 30. 3. Inactivation and Resurgent Current Contribution to Excitability of Sensory Neurons - p. 608 31. 4. Classic Sodium Currents Role in Pain - p. 612 32. 5. Atypical Sodium Currents and Pain - p. 615 33. 6. Therapeutic Strategies - p. 622 34. Index - p. 639
