Nanocarriers Based Colon Targeting: Design, Development, Mechanism and Case Studies unveils a groundbreaking exploration of nanotechnology’s potential in revolutionizing drug delivery for colon-related ailments. Today, an array of colonic diseases, including colorectal cancer, colonic polyps, ulcerative colitis, and inflammatory bowel syndrome, pose significant medical challenges. Conventional methods to deliver drugs to this system prove difficult, with limited efficacy and notable side effects. This book delves into the intricate complexities of colonic diseases, their pathophysiology, and epidemiology to support pharmaceutical scientists in designing better drug delivery systems. Providing a comprehensive overview of the area, the chapters elucidate diverse targeting strategies, from time-dependent to microbiota-based drug delivery systems, and explore receptor-based and magnetically assisted delivery mechanisms. Case studies dissected the working mechanisms behind polymeric nanoparticles, polymersomes, polymeric micelles, solid lipid nanoparticles, and other nanocarrier systems tailored for colon targeting. Additionally, this book explores cuttingedge topics such as gold nanoparticles, supra-magnetic iron oxide nanoparticles, and protein–peptide-based nanoparticles, highlighting their mechanisms, applications, and potential toxicities. Merging an overview of colonic pathophysiology with in-depth reviews of each nanomaterial used for drug delivery and practical case studies, Nanocarriers Based Colon Targeting: Design, Development, Mechanism and Case Studies is a complete reference for pharmaceutical scientists involved in elevating drug delivery precision and therapeutic efficacy in this organ system. Toxicologists, material scientists, research physicians, and regulators can also benefit from the case studies developed by expert authors.
1. Title of Book - p. i 2. Cover image - p. i 3. Title page - p. ii 4. Table of Contents - p. iii 5. Copyright - p. iv 6. Contributors - p. xxv 7. Chapter 1. An overview on colonic diseases - p. 1 8. Chapter 2. Colonic disease—Targeting strategies - p. 41 9. Chapter 3. Nanocarriers for the colonic diseases - p. 71 10. Chapter 4. Applications of nanocarriers in colon targeting - p. 83 11. Chapter 5. Polymeric nanoparticles in colon targeting - p. 115 12. Chapter 6. Polymersomes in colon targeting - p. 151 13. Chapter 7. Polymeric micelles in colon targeting - p. 171 14. Chapter 8. Solid lipid nanoparticles in colon targeting - p. 195 15. Chapter 9. Nanostructured lipid carriers in colon targeting - p. 221 16. Chapter 10. Liposomes in colon targeting - p. 247 17. Chapter 11. Carbon-based nanomaterials in colon cancer targeting - p. 261 18. Chapter 12. Gold nanoparticles in colon targeting - p. 285 19. Chapter 13. Supramagnetic iron oxide nanoparticles for colon targeting - p. 313 20. Chapter 14. Magnetic triblock copolymer nanoparticles in colon targeting - p. 339 21. Chapter 15. Dendrimer nanoparticles for colon targeting - p. 375 22. Chapter 16. Emerging trends of mesoporous silica nanoparticles in colon targeting - p. 395 23. Chapter 17. Redox nanoparticles in colon drug targeting - p. 423 24. Chapter 18. State of the art application for protein and peptides in colon targeting - p. 465 25. Chapter 19. Hybrid nanoparticles in colon targeting - p. 509 26. Chapter 20. Polysaccharide-based nanocarriers in colon targeting drug delivery system - p. 531 27. Chapter 21. Nanocrystal based approach in colon targeting - p. 569 28. Chapter 22. Nano based enemas for colon targeting - p. 601 29. Chapter 23. Exosomes in colon targeting - p. 631 30. Chapter 24. Nanocarriers in inflammatory bowel disease and colorectal cancer - p. 657 31. Chapter 25. Self nanoemulsifying drug delivery systems in colon targeting - p. 689 32. Chapter 26. Preclinical and clinical status of nanocarriers for colon targeting - p. 717 33. Chapter 27. Regulatory issues and toxicological concerns related to nanocarriers - p. 759 34. Index - p. 795
Nanocarriers Based Colon Targeting: Design, Development, Mechanism and Case Studies unveils a groundbreaking exploration of nanotechnology’s potential in revolutionizing drug delivery for colon-related ailments. Today, an array of colonic diseases, including colorectal cancer, colonic polyps, ulcerative colitis, and inflammatory bowel syndrome, pose significant medical challenges. Conventional methods to deliver drugs to this system prove difficult, with limited efficacy and notable side effects. This book delves into the intricate complexities of colonic diseases, their pathophysiology, and epidemiology to support pharmaceutical scientists in designing better drug delivery systems. Providing a comprehensive overview of the area, the chapters elucidate diverse targeting strategies, from time-dependent to microbiota-based drug delivery systems, and explore receptor-based and magnetically assisted delivery mechanisms. Case studies dissected the working mechanisms behind polymeric nanoparticles, polymersomes, polymeric micelles, solid lipid nanoparticles, and other nanocarrier systems tailored for colon targeting. Additionally, this book explores cuttingedge topics such as gold nanoparticles, supra-magnetic iron oxide nanoparticles, and protein–peptide-based nanoparticles, highlighting their mechanisms, applications, and potential toxicities. Merging an overview of colonic pathophysiology with in-depth reviews of each nanomaterial used for drug delivery and practical case studies, Nanocarriers Based Colon Targeting: Design, Development, Mechanism and Case Studies is a complete reference for pharmaceutical scientists involved in elevating drug delivery precision and therapeutic efficacy in this organ system. Toxicologists, material scientists, research physicians, and regulators can also benefit from the case studies developed by expert authors.
1. Title of Book - p. i 2. Cover image - p. i 3. Title page - p. ii 4. Table of Contents - p. iii 5. Copyright - p. iv 6. Contributors - p. xxv 7. Chapter 1. An overview on colonic diseases - p. 1 8. Chapter 2. Colonic disease—Targeting strategies - p. 41 9. Chapter 3. Nanocarriers for the colonic diseases - p. 71 10. Chapter 4. Applications of nanocarriers in colon targeting - p. 83 11. Chapter 5. Polymeric nanoparticles in colon targeting - p. 115 12. Chapter 6. Polymersomes in colon targeting - p. 151 13. Chapter 7. Polymeric micelles in colon targeting - p. 171 14. Chapter 8. Solid lipid nanoparticles in colon targeting - p. 195 15. Chapter 9. Nanostructured lipid carriers in colon targeting - p. 221 16. Chapter 10. Liposomes in colon targeting - p. 247 17. Chapter 11. Carbon-based nanomaterials in colon cancer targeting - p. 261 18. Chapter 12. Gold nanoparticles in colon targeting - p. 285 19. Chapter 13. Supramagnetic iron oxide nanoparticles for colon targeting - p. 313 20. Chapter 14. Magnetic triblock copolymer nanoparticles in colon targeting - p. 339 21. Chapter 15. Dendrimer nanoparticles for colon targeting - p. 375 22. Chapter 16. Emerging trends of mesoporous silica nanoparticles in colon targeting - p. 395 23. Chapter 17. Redox nanoparticles in colon drug targeting - p. 423 24. Chapter 18. State of the art application for protein and peptides in colon targeting - p. 465 25. Chapter 19. Hybrid nanoparticles in colon targeting - p. 509 26. Chapter 20. Polysaccharide-based nanocarriers in colon targeting drug delivery system - p. 531 27. Chapter 21. Nanocrystal based approach in colon targeting - p. 569 28. Chapter 22. Nano based enemas for colon targeting - p. 601 29. Chapter 23. Exosomes in colon targeting - p. 631 30. Chapter 24. Nanocarriers in inflammatory bowel disease and colorectal cancer - p. 657 31. Chapter 25. Self nanoemulsifying drug delivery systems in colon targeting - p. 689 32. Chapter 26. Preclinical and clinical status of nanocarriers for colon targeting - p. 717 33. Chapter 27. Regulatory issues and toxicological concerns related to nanocarriers - p. 759 34. Index - p. 795
