Nanotechnology Methods for Neurological Diseases and Brain Tumors: Drug Delivery across the Blood-Brain Barrier compiles the latest (and future potential) treatment strategies for brain tumors and neurological diseases, in particular Alzheimer’s, Parkinson’s and stroke, those that bypass the blood/brain barrier.
The current understanding of brain drug delivery and access is discussed in Chapter One, with the next section focusing on the implementation of the nose-to-brain intranasal route in brain-targeted drug delivery.
In addition, nanotechnology-based brain drug delivery is covered in Chapter Three. This avenue offers impressive improvement in the treatment of neurological diseases and brain tumors by using bio-engineered systems that interact with biological systems at a molecular level. In Chapter Four, emphasis is placed on the need for brain-targeted experimental models that mimic disease conditions. Final chapters discuss the very latest advances in targeted treatment strategies for neurological diseases and brain tumors.
1. Cover - p. i 2. Title page - p. iii 3. Table of Contents - p. iii 4. Copyright - p. ii 5. List of Contributors - p. iv 6. About the Editors - p. xii 7. Preface - p. xiv 8. Part 1: The Rationale to Reach the Brain - p. xvi 9. Chapter 1: Anatomy and Physiology of the Blood–Brain Barrier - p. xvi 10. Chapter 2: Blood–Brain Barrier: Genomics, Proteomics, Disease Targets, and Drug Delivery - p. 13 11. Chapter 3: Brain and the Drug Transporters - p. 34 12. Chapter 4: Drug Delivery to the Brain: Pharmacokinetic Concepts - p. 67 13. Part 2: Nose-to-Brain Drug Delivery - p. 90 14. Chapter 5: Nasal Physiology and Drug Transport - p. 90 15. Chapter 6: Challenges of the Nose-to-Brain Route - p. 102 16. Part 3: Nanoscience in Targeted Brain Drug Delivery - p. 113 17. Chapter 7: Nanoscience in Targeted Brain Drug Delivery - p. 113 18. Part 4: Brain-Targeted Experimental Models - p. 147 19. Chapter 8: In Vitro CNS Models - p. 147 20. Chapter 9: In Vivo/In Situ Animal Models - p. 185 21. Chapter 10: Microdialysis and Brain Perfusion - p. 195 22. Chapter 11: Neuroimaging: Techniques and General Applications - p. 207 23. Part 5: Targeted Treatment Strategies for Neurological Diseases - p. 224 24. Chapter 12: Alzheimer - p. 224 25. Chapter 13: Parkinson’s Disease - p. 239 26. Chapter 14: Stroke - p. 269 27. Chapter 15: Nanotechnology-Based Management of Neurological Autoimmune Diseases - p. 278 28. Chapter 16: Infectious Diseases of the Brain - p. 290 29. Part 6: Brain Tumors - p. 315 30. Chapter 17: Brain Tumors - p. 315 31. Future Outlook - p. 344 32. Index - p. 346
Nanotechnology Methods for Neurological Diseases and Brain Tumors: Drug Delivery across the Blood-Brain Barrier compiles the latest (and future potential) treatment strategies for brain tumors and neurological diseases, in particular Alzheimer’s, Parkinson’s and stroke, those that bypass the blood/brain barrier.
The current understanding of brain drug delivery and access is discussed in Chapter One, with the next section focusing on the implementation of the nose-to-brain intranasal route in brain-targeted drug delivery.
In addition, nanotechnology-based brain drug delivery is covered in Chapter Three. This avenue offers impressive improvement in the treatment of neurological diseases and brain tumors by using bio-engineered systems that interact with biological systems at a molecular level. In Chapter Four, emphasis is placed on the need for brain-targeted experimental models that mimic disease conditions. Final chapters discuss the very latest advances in targeted treatment strategies for neurological diseases and brain tumors.
1. Cover - p. i 2. Title page - p. iii 3. Table of Contents - p. iii 4. Copyright - p. ii 5. List of Contributors - p. iv 6. About the Editors - p. xii 7. Preface - p. xiv 8. Part 1: The Rationale to Reach the Brain - p. xvi 9. Chapter 1: Anatomy and Physiology of the Blood–Brain Barrier - p. xvi 10. Chapter 2: Blood–Brain Barrier: Genomics, Proteomics, Disease Targets, and Drug Delivery - p. 13 11. Chapter 3: Brain and the Drug Transporters - p. 34 12. Chapter 4: Drug Delivery to the Brain: Pharmacokinetic Concepts - p. 67 13. Part 2: Nose-to-Brain Drug Delivery - p. 90 14. Chapter 5: Nasal Physiology and Drug Transport - p. 90 15. Chapter 6: Challenges of the Nose-to-Brain Route - p. 102 16. Part 3: Nanoscience in Targeted Brain Drug Delivery - p. 113 17. Chapter 7: Nanoscience in Targeted Brain Drug Delivery - p. 113 18. Part 4: Brain-Targeted Experimental Models - p. 147 19. Chapter 8: In Vitro CNS Models - p. 147 20. Chapter 9: In Vivo/In Situ Animal Models - p. 185 21. Chapter 10: Microdialysis and Brain Perfusion - p. 195 22. Chapter 11: Neuroimaging: Techniques and General Applications - p. 207 23. Part 5: Targeted Treatment Strategies for Neurological Diseases - p. 224 24. Chapter 12: Alzheimer - p. 224 25. Chapter 13: Parkinson’s Disease - p. 239 26. Chapter 14: Stroke - p. 269 27. Chapter 15: Nanotechnology-Based Management of Neurological Autoimmune Diseases - p. 278 28. Chapter 16: Infectious Diseases of the Brain - p. 290 29. Part 6: Brain Tumors - p. 315 30. Chapter 17: Brain Tumors - p. 315 31. Future Outlook - p. 344 32. Index - p. 346
