Natural Molecules in Neuroprotection and Neurotoxicity brings together research in the area of natural compounds and their dual effects of neuroprotection and neurotoxicity when interacting with brain cells. This book is organized into four sections that address molecular mechanism underlying neuroprotection and neurotoxicity, neuroprotection mediated by natural molecules, neurotoxicity induced by natural compounds and nanotechnology-related strategies utilized in neuroprotection.
Written by well-known researchers all over the world, chapters provide an in-depth analysis of numerous molecules, such as algae, plant and fungus-derived molecules, and comprehensively discuss their mechanisms of action and possible clinical applications. This book provides an essential reference for researchers and clinical scientists interested in the effects of natural compounds on the human health and disease.
1. Natural Molecules in Neuroprotection and Neurotoxicity - p. Page i 2. Cover - p. Page i 3. Title page - p. Page ii 4. Table of Contents - p. Page iii 5. Copyright - p. Page iii 6. Dedication - p. Page v 7. Contents - p. Page vii 8. List of contributors - p. Page viii 9. Preface-volume1 - p. Page viii 10. Preface-volume2 - p. Page xi 11. List of Illustrations - p. Page xiv 12. List of Tables - p. Page xv 13. Chapter 1 : Natural molecules in neuroprotection and neurotoxicity in neurodegenerative diseases - p. Page xv 14. Chapter 2 : The sea as a source of neuroprotective and other health-protective molecules - p. Page 17 15. Chapter 3 : Can venoms be used in neuroprotection? - p. Page 46 16. Chapter 4 : Polyphenol-gut microbiota interplay in neuroprotection - p. Page 75 17. Chapter 5 : Medical potentials of natural neuroprotectants derived from herbal extracts and their phytochemicals - p. Page 99 18. Chapter 6 : Redox impairment in affective disorders and therapeutic potential of phenolic bioactive compounds - p. Page 115 19. Chapter 7 : How the endoplasmic reticulum staggers toward failure: new targets for neuroprotection - p. Page 135 20. Chapter 8 : Modulation of neuroinflammation by natural molecules - p. Page 161 21. Chapter 9 : Epigenetic modulations induced by natural products - p. Page 186 22. Chapter 10 : Modulation of enteric glial cells by nutraceuticals during pathological processes - p. Page 217 23. Chapter 11 : Natural molecules in the treatment of schizophrenia - p. Page 252 24. Chapter 12 : Antitumor effects induced by natural molecules in the brain☆ - p. Page 272 25. Chapter 13 : Understanding the neurogenic potential of flavonoids and their application for neurodegenerative diseases - p. Page 315 26. Chapter 14 : Transcriptomics to investigate neurotoxicity and neuroprotection - p. Page 344 27. Chapter 15 : Neuroprotection induced by fucoxanthin - p. Page 365 28. Chapter 16 : C-Phycocyanin and Phycocyanobilin for neuroprotection: a deep dive into the biological processes involved - p. Page 378 29. Chapter 17 : Bee venom and neuroprotection - p. Page 395 30. Chapter 18 : Frog-derived peptides and neuroprotection - p. Page 410 31. Chapter 19 : Neuroprotection mediated by snake venom - p. Page 429 32. Chapter 20 : Spider toxins - p. Page 446 33. Chapter 21 : Endogenous molecules in neuroprotection: Acetyl-L-carnitine - p. Page 465 34. Chapter 22 : Neuroprotective potential of coenzyme Q10 - p. Page 485 35. Chapter 23 : Creatine in neuroprotection and neurotoxicity - p. Page 504 36. Chapter 24 : Neuroprotection induced by erythropoietin - p. Page 521 37. Chapter 25 : Neuroprotection by estrogens - p. Page 538 38. Chapter 26 : Sex hormones in neuroprotection and neurodegeneration - p. Page 561 39. Chapter 27 : Neuroprotective efficacy of melatonin in the pathophysiology of neurodegenerative disorders - p. Page 596 40. Chapter 28 : Neuroprotection induced by neurotrophic factors - p. Page 628 41. Chapter 29 : Neuroprotection induced by nucleosides - p. Page 647 42. Chapter 30 : Taurine role in neuroprotection - p. Page 672 43. Chapter 31 : Neurotoxicity of Clostridium perfringens type D enterotoxemia - p. Page 692 44. Chapter 32 : Neurotoxicity induced by cyanobacteria-derived molecules - p. Page 712 45. Chapter 33 : Neurotoxicity induced by the microbial metabolite β-methylamino-L-alanine: pathways and mechanisms - p. Page 736 46. Chapter 34 : Domoic acid: experimental and clinical neurotoxicity in vivo - p. Page 766 47. Chapter 35 : Neurotoxicity induced by caffeine in the thalamocortical system: role of intracellular calcium-dependent mechanisms and intrinsic properties - p. Page 792 48. Chapter 36 : Neurotoxicity and neuroprotection induced by plant-derived cannabinoids - p. Page 818 49. Chapter 37 : Ureases: neurotoxicity of Canavalia ensiformis ureases in the rodent and insect nervous systems - p. Page 862 50. Chapter 38 : Neurotoxicity induced by scorpion venom - p. Page 899 51. Chapter 39 : Anuran-derived molecules from the Pampa biome in southern Brazil - p. Page 922 52. Chapter 40 : Cellular and molecular mechanisms of ammonia-induced neurotoxicity: a neurotherapeutic prospect - p. Page 950 53. Chapter 41 : Neurotoxicity induced by biliverdin and bilirubin - p. Page 979 54. Chapter 42 : Neurotoxicity induced by glycotoxins - p. Page 1016 55. Chapter 43 : Amyloids as endogenous toxicants in neurodegenerative diseases - p. Page 1046 56. Chapter 44 : Neurotoxicity induced by lipid metabolism–associated endogenous toxicants - p. Page 1071 57. Chapter 45 : Neuroprotection induced by agathisflavone - p. Page 1098 58. Chapter 46 : Neuroprotection induced by plant alkaloids - p. Page 1155 59. Chapter 47 : Overview of the effects of andrographolide on disorders of the central nervous system - p. Page 1186 60. Chapter 48 : Anthocyanins - p. Page 1212 61. Chapter 49 : Neuroprotection induced by apigenin - p. Page 1234 62. Chapter 50 : Neuroprotection induced by ascorbic acid - p. Page 1256 63. Chapter 51 : Neuroprotection induced by baicalein and baicalin - p. Page 1279 64. Chapter 52 : Unveiling the neuroprotective benefits of biochanin-A - p. Page 1301 65. Chapter 53 : Neuroprotection induced by epigallocatechin-3-gallate - p. Page 1316 66. Chapter 54 : Carnosic acid, mitochondria, and neuroprotection - p. Page 1333 67. Chapter 55 : Neuroprotection induced by catechins in aging - p. Page 1345 68. Chapter 56 : Neuroprotection induced by chrysin - p. Page 1356 69. Chapter 57 : Citrus flavonoids—Mechanisms of neuroprotection and preclinical evidence - p. Page 1376 70. Chapter 58 : Neuroprotection induced by coumarins in central nervous system disease models - p. Page 1401 71. Chapter 59 : Neuroprotection induced by curcumin - p. Page 1432 72. Chapter 60 : Neuroprotection induced by dimethyl fumarate - p. Page 1455 73. Chapter 61 : Neuroprotection induced by edible oils - p. Page 1481 74. Chapter 62 : Neuroprotective role of garlic constituents against neurological disorders - p. Page 1500 75. Chapter 63 : Neuroprotection by ginger and its components in neurodegenerative diseases - p. Page 1520 76. Chapter 64 : Green tea polyphenols for neuroprotection: effects against Alzheimer’s and Parkinson’s diseases - p. Page 1538 77. Chapter 65 : Neuroprotection induced by honey compounds - p. Page 1554 78. Chapter 66 : Neuroprotective actions of hydroxytyrosol - p. Page 1580 79. Chapter 67 : Hydroxytyrosol: focus on the antineuroinflammatory action - p. Page 1600 80. Chapter 68 : Neuroprotection induced by kaempferol - p. Page 1616 81. Chapter 69 : Neuroprotection induced by lycopene - p. Page 1633 82. Chapter 70 : Neuroprotection induced by terpenes: focus on Alzheimer’s disease and Parkinson’s disease - p. Page 1661 83. Chapter 71 : Neuroprotection induced by olive oil components - p. Page 1677 84. Chapter 72 : Neuroprotection induced by omega-3 polyunsaturated fatty acids: focus on neuropsychiatric disorders - p. Page 1694 85. Chapter 73 : Neuroprotective potential of dihydrochalcones: phloretin and phloridzin - p. Page 1714 86. Chapter 74 : Neuroprotection induced by phytomelatonin - p. Page 1732 87. Chapter 75 : Neuroprotection induced by quercetin - p. Page 1750 88. Chapter 76 : Neuroprotection induced by salvianolic acids - p. Page 1775 89. Chapter 77 : Neuroprotection induced by sulphoraphane in central nervous system disorders - p. Page 1808 90. Chapter 78 : Effects of tocopherols and tocotrienols on microglia-mediated neuroprotection - p. Page 1831 91. Chapter 79 : Vanillin: a natural phenolic compound with neuroprotective benefits - p. Page 1849 92. Chapter 80 : Neuroprotection through nanotechnology - p. Page 1875 93. Chapter 81 : Natural antioxidant nanoparticles in neuroprotection - p. Page 1898 94. Chapter 82 : Nanomaterial-based approach in stroke - p. Page 1923 95. Chapter 83 : Nanoparticles and treatment of depression - p. Page 1951 96. Chapter 84 : Antitumor effects of natural molecules in the brain: a nanotechnology-based approach - p. Page 1980 97. Index-Volume1 - p. Page 2009 98. Index-Volume2 - p. Page 1143
Natural Molecules in Neuroprotection and Neurotoxicity brings together research in the area of natural compounds and their dual effects of neuroprotection and neurotoxicity when interacting with brain cells. This book is organized into four sections that address molecular mechanism underlying neuroprotection and neurotoxicity, neuroprotection mediated by natural molecules, neurotoxicity induced by natural compounds and nanotechnology-related strategies utilized in neuroprotection.
Written by well-known researchers all over the world, chapters provide an in-depth analysis of numerous molecules, such as algae, plant and fungus-derived molecules, and comprehensively discuss their mechanisms of action and possible clinical applications. This book provides an essential reference for researchers and clinical scientists interested in the effects of natural compounds on the human health and disease.
1. Natural Molecules in Neuroprotection and Neurotoxicity - p. Page i 2. Cover - p. Page i 3. Title page - p. Page ii 4. Table of Contents - p. Page iii 5. Copyright - p. Page iii 6. Dedication - p. Page v 7. Contents - p. Page vii 8. List of contributors - p. Page viii 9. Preface-volume1 - p. Page viii 10. Preface-volume2 - p. Page xi 11. List of Illustrations - p. Page xiv 12. List of Tables - p. Page xv 13. Chapter 1 : Natural molecules in neuroprotection and neurotoxicity in neurodegenerative diseases - p. Page xv 14. Chapter 2 : The sea as a source of neuroprotective and other health-protective molecules - p. Page 17 15. Chapter 3 : Can venoms be used in neuroprotection? - p. Page 46 16. Chapter 4 : Polyphenol-gut microbiota interplay in neuroprotection - p. Page 75 17. Chapter 5 : Medical potentials of natural neuroprotectants derived from herbal extracts and their phytochemicals - p. Page 99 18. Chapter 6 : Redox impairment in affective disorders and therapeutic potential of phenolic bioactive compounds - p. Page 115 19. Chapter 7 : How the endoplasmic reticulum staggers toward failure: new targets for neuroprotection - p. Page 135 20. Chapter 8 : Modulation of neuroinflammation by natural molecules - p. Page 161 21. Chapter 9 : Epigenetic modulations induced by natural products - p. Page 186 22. Chapter 10 : Modulation of enteric glial cells by nutraceuticals during pathological processes - p. Page 217 23. Chapter 11 : Natural molecules in the treatment of schizophrenia - p. Page 252 24. Chapter 12 : Antitumor effects induced by natural molecules in the brain☆ - p. Page 272 25. Chapter 13 : Understanding the neurogenic potential of flavonoids and their application for neurodegenerative diseases - p. Page 315 26. Chapter 14 : Transcriptomics to investigate neurotoxicity and neuroprotection - p. Page 344 27. Chapter 15 : Neuroprotection induced by fucoxanthin - p. Page 365 28. Chapter 16 : C-Phycocyanin and Phycocyanobilin for neuroprotection: a deep dive into the biological processes involved - p. Page 378 29. Chapter 17 : Bee venom and neuroprotection - p. Page 395 30. Chapter 18 : Frog-derived peptides and neuroprotection - p. Page 410 31. Chapter 19 : Neuroprotection mediated by snake venom - p. Page 429 32. Chapter 20 : Spider toxins - p. Page 446 33. Chapter 21 : Endogenous molecules in neuroprotection: Acetyl-L-carnitine - p. Page 465 34. Chapter 22 : Neuroprotective potential of coenzyme Q10 - p. Page 485 35. Chapter 23 : Creatine in neuroprotection and neurotoxicity - p. Page 504 36. Chapter 24 : Neuroprotection induced by erythropoietin - p. Page 521 37. Chapter 25 : Neuroprotection by estrogens - p. Page 538 38. Chapter 26 : Sex hormones in neuroprotection and neurodegeneration - p. Page 561 39. Chapter 27 : Neuroprotective efficacy of melatonin in the pathophysiology of neurodegenerative disorders - p. Page 596 40. Chapter 28 : Neuroprotection induced by neurotrophic factors - p. Page 628 41. Chapter 29 : Neuroprotection induced by nucleosides - p. Page 647 42. Chapter 30 : Taurine role in neuroprotection - p. Page 672 43. Chapter 31 : Neurotoxicity of Clostridium perfringens type D enterotoxemia - p. Page 692 44. Chapter 32 : Neurotoxicity induced by cyanobacteria-derived molecules - p. Page 712 45. Chapter 33 : Neurotoxicity induced by the microbial metabolite β-methylamino-L-alanine: pathways and mechanisms - p. Page 736 46. Chapter 34 : Domoic acid: experimental and clinical neurotoxicity in vivo - p. Page 766 47. Chapter 35 : Neurotoxicity induced by caffeine in the thalamocortical system: role of intracellular calcium-dependent mechanisms and intrinsic properties - p. Page 792 48. Chapter 36 : Neurotoxicity and neuroprotection induced by plant-derived cannabinoids - p. Page 818 49. Chapter 37 : Ureases: neurotoxicity of Canavalia ensiformis ureases in the rodent and insect nervous systems - p. Page 862 50. Chapter 38 : Neurotoxicity induced by scorpion venom - p. Page 899 51. Chapter 39 : Anuran-derived molecules from the Pampa biome in southern Brazil - p. Page 922 52. Chapter 40 : Cellular and molecular mechanisms of ammonia-induced neurotoxicity: a neurotherapeutic prospect - p. Page 950 53. Chapter 41 : Neurotoxicity induced by biliverdin and bilirubin - p. Page 979 54. Chapter 42 : Neurotoxicity induced by glycotoxins - p. Page 1016 55. Chapter 43 : Amyloids as endogenous toxicants in neurodegenerative diseases - p. Page 1046 56. Chapter 44 : Neurotoxicity induced by lipid metabolism–associated endogenous toxicants - p. Page 1071 57. Chapter 45 : Neuroprotection induced by agathisflavone - p. Page 1098 58. Chapter 46 : Neuroprotection induced by plant alkaloids - p. Page 1155 59. Chapter 47 : Overview of the effects of andrographolide on disorders of the central nervous system - p. Page 1186 60. Chapter 48 : Anthocyanins - p. Page 1212 61. Chapter 49 : Neuroprotection induced by apigenin - p. Page 1234 62. Chapter 50 : Neuroprotection induced by ascorbic acid - p. Page 1256 63. Chapter 51 : Neuroprotection induced by baicalein and baicalin - p. Page 1279 64. Chapter 52 : Unveiling the neuroprotective benefits of biochanin-A - p. Page 1301 65. Chapter 53 : Neuroprotection induced by epigallocatechin-3-gallate - p. Page 1316 66. Chapter 54 : Carnosic acid, mitochondria, and neuroprotection - p. Page 1333 67. Chapter 55 : Neuroprotection induced by catechins in aging - p. Page 1345 68. Chapter 56 : Neuroprotection induced by chrysin - p. Page 1356 69. Chapter 57 : Citrus flavonoids—Mechanisms of neuroprotection and preclinical evidence - p. Page 1376 70. Chapter 58 : Neuroprotection induced by coumarins in central nervous system disease models - p. Page 1401 71. Chapter 59 : Neuroprotection induced by curcumin - p. Page 1432 72. Chapter 60 : Neuroprotection induced by dimethyl fumarate - p. Page 1455 73. Chapter 61 : Neuroprotection induced by edible oils - p. Page 1481 74. Chapter 62 : Neuroprotective role of garlic constituents against neurological disorders - p. Page 1500 75. Chapter 63 : Neuroprotection by ginger and its components in neurodegenerative diseases - p. Page 1520 76. Chapter 64 : Green tea polyphenols for neuroprotection: effects against Alzheimer’s and Parkinson’s diseases - p. Page 1538 77. Chapter 65 : Neuroprotection induced by honey compounds - p. Page 1554 78. Chapter 66 : Neuroprotective actions of hydroxytyrosol - p. Page 1580 79. Chapter 67 : Hydroxytyrosol: focus on the antineuroinflammatory action - p. Page 1600 80. Chapter 68 : Neuroprotection induced by kaempferol - p. Page 1616 81. Chapter 69 : Neuroprotection induced by lycopene - p. Page 1633 82. Chapter 70 : Neuroprotection induced by terpenes: focus on Alzheimer’s disease and Parkinson’s disease - p. Page 1661 83. Chapter 71 : Neuroprotection induced by olive oil components - p. Page 1677 84. Chapter 72 : Neuroprotection induced by omega-3 polyunsaturated fatty acids: focus on neuropsychiatric disorders - p. Page 1694 85. Chapter 73 : Neuroprotective potential of dihydrochalcones: phloretin and phloridzin - p. Page 1714 86. Chapter 74 : Neuroprotection induced by phytomelatonin - p. Page 1732 87. Chapter 75 : Neuroprotection induced by quercetin - p. Page 1750 88. Chapter 76 : Neuroprotection induced by salvianolic acids - p. Page 1775 89. Chapter 77 : Neuroprotection induced by sulphoraphane in central nervous system disorders - p. Page 1808 90. Chapter 78 : Effects of tocopherols and tocotrienols on microglia-mediated neuroprotection - p. Page 1831 91. Chapter 79 : Vanillin: a natural phenolic compound with neuroprotective benefits - p. Page 1849 92. Chapter 80 : Neuroprotection through nanotechnology - p. Page 1875 93. Chapter 81 : Natural antioxidant nanoparticles in neuroprotection - p. Page 1898 94. Chapter 82 : Nanomaterial-based approach in stroke - p. Page 1923 95. Chapter 83 : Nanoparticles and treatment of depression - p. Page 1951 96. Chapter 84 : Antitumor effects of natural molecules in the brain: a nanotechnology-based approach - p. Page 1980 97. Index-Volume1 - p. Page 2009 98. Index-Volume2 - p. Page 1143
