Natural Product Drug Discovery: Highly Anticipated Natural Molecules, a new volume in the Drug Discovery Opinion series, provides a comprehensive examination of the role of natural products in innovative drug development. The book addresses the significant challenges that highly active natural molecules face in the drug development process, including issues related to bioavailability and potency. Sections present analyses of various classes of natural products, including polysaccharides, volatile oils, and diterpenoids, exploring their chemical properties, biological activities, and potential clinical applications. Each chapter, written by leading experts, offers insights into structural modification techniques, naturally sourced inhibitors, and the application of green biomanufacturing strategies.
It will serve as an essential resource for researchers, pharmacologists, and industry professionals involved in natural product drug discovery. Readers will find the necessary information to navigate the complexities of the field, emphasizing the integration of traditional knowledge with modern scientific approaches. Through a thorough understanding of these natural compounds, this book aims to contribute to the advancement of therapeutic innovations in pharmacotherapy.
1. Title of Book - p. i 2. Cover image - p. i 3. Title page - p. ii 4. Table of Contents - p. iii 5. Copyright - p. iv 6. List of contributors - p. xi 7. Preface - p. xv 8. Acknowledgments - p. xvii 9. Chapter 1. The key technology in drug discovery: structural modification of natural products - p. 1 10. Chapter 2. Naturally sourced sodium-glucose cotransporter 2 inhibitors for hypoglycemic: using sugar against sugar - p. 35 11. Chapter 3. Polysaccharides from TCM as an important resource of new drugs for osteoporosis and neurodegenerative diseases - p. 47 12. Chapter 4. Drug discovery from daphnane-type diterpenoids: a balance between the anti-HIV effect and toxicity - p. 65 13. Chapter 5. The promising future of eudesmanolides: a potential source of new drugs - p. 99 14. Chapter 6. Natural products as potential therapeutic candidates against chronic obstructive pulmonary disease - p. 175 15. Chapter 7. Right time for drug development from volatile oils - p. 201 16. Chapter 8. Natural products in Alzheimer's disease - p. 205 17. Marine N-heterocycle macrolides - p. 217 18. Chapter 10. Cardiac glycosides: potential antineoplastic candidates from a medication of heart failure and atrial arrhythmia - p. 237 19. Chapter 11. Natural products as potential neuroprotective agents for ischemic stroke - p. 273 20. Chapter 12. Key strategy for drug development: green biomanufacturing of active natural products - p. 293 21. Chapter 13. Research and development of the antitumor star molecule Taxol - p. 325 22. Chapter 14. Natural products as modulators of bile acid receptor FXR: therapeutic opportunities and challenges in drug discovery - p. 345 23. Chapter 15. Natural cephalotaxus alkaloids from Cephalotaxaceae as a source of new anticancer drugs - p. 365 24. Chapter 16. Computation-enabled natural products drug discovery - p. 387 25. Chapter 17. Active metabolites derived from microorganisms of extreme environments - p. 405 26. Index - p. 443
Natural Product Drug Discovery: Highly Anticipated Natural Molecules, a new volume in the Drug Discovery Opinion series, provides a comprehensive examination of the role of natural products in innovative drug development. The book addresses the significant challenges that highly active natural molecules face in the drug development process, including issues related to bioavailability and potency. Sections present analyses of various classes of natural products, including polysaccharides, volatile oils, and diterpenoids, exploring their chemical properties, biological activities, and potential clinical applications. Each chapter, written by leading experts, offers insights into structural modification techniques, naturally sourced inhibitors, and the application of green biomanufacturing strategies.
It will serve as an essential resource for researchers, pharmacologists, and industry professionals involved in natural product drug discovery. Readers will find the necessary information to navigate the complexities of the field, emphasizing the integration of traditional knowledge with modern scientific approaches. Through a thorough understanding of these natural compounds, this book aims to contribute to the advancement of therapeutic innovations in pharmacotherapy.
1. Title of Book - p. i 2. Cover image - p. i 3. Title page - p. ii 4. Table of Contents - p. iii 5. Copyright - p. iv 6. List of contributors - p. xi 7. Preface - p. xv 8. Acknowledgments - p. xvii 9. Chapter 1. The key technology in drug discovery: structural modification of natural products - p. 1 10. Chapter 2. Naturally sourced sodium-glucose cotransporter 2 inhibitors for hypoglycemic: using sugar against sugar - p. 35 11. Chapter 3. Polysaccharides from TCM as an important resource of new drugs for osteoporosis and neurodegenerative diseases - p. 47 12. Chapter 4. Drug discovery from daphnane-type diterpenoids: a balance between the anti-HIV effect and toxicity - p. 65 13. Chapter 5. The promising future of eudesmanolides: a potential source of new drugs - p. 99 14. Chapter 6. Natural products as potential therapeutic candidates against chronic obstructive pulmonary disease - p. 175 15. Chapter 7. Right time for drug development from volatile oils - p. 201 16. Chapter 8. Natural products in Alzheimer's disease - p. 205 17. Marine N-heterocycle macrolides - p. 217 18. Chapter 10. Cardiac glycosides: potential antineoplastic candidates from a medication of heart failure and atrial arrhythmia - p. 237 19. Chapter 11. Natural products as potential neuroprotective agents for ischemic stroke - p. 273 20. Chapter 12. Key strategy for drug development: green biomanufacturing of active natural products - p. 293 21. Chapter 13. Research and development of the antitumor star molecule Taxol - p. 325 22. Chapter 14. Natural products as modulators of bile acid receptor FXR: therapeutic opportunities and challenges in drug discovery - p. 345 23. Chapter 15. Natural cephalotaxus alkaloids from Cephalotaxaceae as a source of new anticancer drugs - p. 365 24. Chapter 16. Computation-enabled natural products drug discovery - p. 387 25. Chapter 17. Active metabolites derived from microorganisms of extreme environments - p. 405 26. Index - p. 443
