Neural Repair and Regeneration after Spinal Cord Injury and Spine Trauma provides readers with a comprehensive overview on the most up-to-date strategies to repair and regenerate the injured spinal cord following SCI and spine trauma. With contributions by international authors, chapters put regenerative approaches in context, allowing the reader to understand the challenges and future directions of regenerative therapies. Recent clinical trial advancements are thoroughly discussed, with the impact of trial findings addressed. Additionally, major ongoing clinical trials are included with thoughts from experts in the field. Recent clinical practice guidelines for the management of traumatic spinal cord injury are featured throughout.
These guidelines are quickly being adopted as the standard of care worldwide, and the comprehensive information found within this book will place these recommendations in context with current knowledge surrounding spinal cord injury and spine trauma.
1. Introduction - p. xxv 2. Chapter 1. Anatomy - p. 1 3. Chapter 2. Epidemiology - p. 13 4. Chapter 3. Classification systems: spine trauma - p. 37 5. Chapter 4. Classification systems: SCI - p. 63 6. Chapter 5. Outcome measures - p. 75 7. Chapter 6. Imaging: spine trauma - p. 89 8. Chapter 7. Advanced imaging for spinal cord injury - p. 105 9. Chapter 8. Intraoperative imaging and image guidance - p. 125 10. Chapter 9. Upper cervical spine and spinal cord injuries - p. 149 11. Chapter 10. Spine trauma management issues: C-spine - p. 167 12. Chapter 11. Spine trauma management issues: thoracic and lumbar - p. 191 13. Chapter 12. Spine trauma: sacral fractures - p. 211 14. Chapter 13. Spine trauma management issues: polytrauma - p. 247 15. Chapter 14. Spine trauma in the elderly – management issues and treatment goals - p. 259 16. Chapter 15. Spine Trauma: areas of controversy and Emerging Concepts - p. 271 17. Chapter 16. Traumatic central cord injury - p. 289 18. Chapter 17. Management and pathophysiology - p. 303 19. Chapter 18. SCI management: role and timing of surgical intervention - p. 319 20. Chapter 19. Intensive care and drugs after spinal cord injury - p. 335 21. Chapter 20. SCI management: rehabilitation - p. 349 22. Chapter 21. Economic impact of traumatic spinal cord injury - p. 371 23. Chapter 22. Complications and adverse events following traumatic spinal cord injury - p. 385 24. Chapter 23. Neurochemical biomarkers of acute spinal cord injury - p. 401 25. Chapter 24. Clinical trials: pharmacological approaches to enhance neural repair and regeneration after spinal cord injury - p. 411 26. Chapter 25. Clinical trials: cellular regenerative approaches - p. 441 27. Chapter 26. Clinical trials: noncellular regenerative approaches - p. 473 28. Chapter 27. Clinical trials: rehabilitation approaches - p. 501 29. Chapter 28. Neuroprotective strategies: translational perspectives - p. 523 30. Chapter 29. Translational perspective: neuroregenerative strategies and therapeutics for traumatic spinal cord injury - p. 537 31. Chapter 30. Emerging concepts in the clinical management of SCI for the future - p. 575 32. Chapter 31. Translational research in spinal cord injury – What is in the future? - p. 587 33. Index - p. 603
Neural Repair and Regeneration after Spinal Cord Injury and Spine Trauma provides readers with a comprehensive overview on the most up-to-date strategies to repair and regenerate the injured spinal cord following SCI and spine trauma. With contributions by international authors, chapters put regenerative approaches in context, allowing the reader to understand the challenges and future directions of regenerative therapies. Recent clinical trial advancements are thoroughly discussed, with the impact of trial findings addressed. Additionally, major ongoing clinical trials are included with thoughts from experts in the field. Recent clinical practice guidelines for the management of traumatic spinal cord injury are featured throughout.
These guidelines are quickly being adopted as the standard of care worldwide, and the comprehensive information found within this book will place these recommendations in context with current knowledge surrounding spinal cord injury and spine trauma.
1. Introduction - p. xxv 2. Chapter 1. Anatomy - p. 1 3. Chapter 2. Epidemiology - p. 13 4. Chapter 3. Classification systems: spine trauma - p. 37 5. Chapter 4. Classification systems: SCI - p. 63 6. Chapter 5. Outcome measures - p. 75 7. Chapter 6. Imaging: spine trauma - p. 89 8. Chapter 7. Advanced imaging for spinal cord injury - p. 105 9. Chapter 8. Intraoperative imaging and image guidance - p. 125 10. Chapter 9. Upper cervical spine and spinal cord injuries - p. 149 11. Chapter 10. Spine trauma management issues: C-spine - p. 167 12. Chapter 11. Spine trauma management issues: thoracic and lumbar - p. 191 13. Chapter 12. Spine trauma: sacral fractures - p. 211 14. Chapter 13. Spine trauma management issues: polytrauma - p. 247 15. Chapter 14. Spine trauma in the elderly – management issues and treatment goals - p. 259 16. Chapter 15. Spine Trauma: areas of controversy and Emerging Concepts - p. 271 17. Chapter 16. Traumatic central cord injury - p. 289 18. Chapter 17. Management and pathophysiology - p. 303 19. Chapter 18. SCI management: role and timing of surgical intervention - p. 319 20. Chapter 19. Intensive care and drugs after spinal cord injury - p. 335 21. Chapter 20. SCI management: rehabilitation - p. 349 22. Chapter 21. Economic impact of traumatic spinal cord injury - p. 371 23. Chapter 22. Complications and adverse events following traumatic spinal cord injury - p. 385 24. Chapter 23. Neurochemical biomarkers of acute spinal cord injury - p. 401 25. Chapter 24. Clinical trials: pharmacological approaches to enhance neural repair and regeneration after spinal cord injury - p. 411 26. Chapter 25. Clinical trials: cellular regenerative approaches - p. 441 27. Chapter 26. Clinical trials: noncellular regenerative approaches - p. 473 28. Chapter 27. Clinical trials: rehabilitation approaches - p. 501 29. Chapter 28. Neuroprotective strategies: translational perspectives - p. 523 30. Chapter 29. Translational perspective: neuroregenerative strategies and therapeutics for traumatic spinal cord injury - p. 537 31. Chapter 30. Emerging concepts in the clinical management of SCI for the future - p. 575 32. Chapter 31. Translational research in spinal cord injury – What is in the future? - p. 587 33. Index - p. 603
