The Neurobiology of Bipolar Disorder: Road to Novel Therapeutics combines the basic neurobiology of bipolar disorder with discussions of the most recent advances in research, including the interacting pathways implicated in the pathophysiology of bipolar disorder, genetic approaches and the pharmacogenomics of bipolar disorder. The basic foundational understanding of the neurobiology underlying the disorder, along with a comprehensive summary of the most recent advances in research combine to aid advanced students and researchers in their understanding of bipolar disorder management using novel and fast-acting pharmaceutical and neuromodulatory approaches.
1. Cover image - p. page_i 2. Title page - p. page_i 3. Table of Contents - p. page_i 4. Copyright - p. page_iv 5. Contributors - p. page_xv 6. Foreword - p. page_xxi 7. Chapter 1: Tackling the heterogeneity of bipolar disorder in the era of the Research Domain Criteria (RDoC) - p. page_1 8. Chapter 2: The neurodevelopmental basis of bipolar disorder: Mechanisms and implications - p. page_11 9. Chapter 3: The neuroprogressive nature of bipolar disorder: Mechanisms and implications - p. page_23 10. Chapter 4: Immune mechanisms in bipolar disorder: Evidence and implications - p. page_37 11. Chapter 5: Mitochondrial pathways in bipolar disorder: Mechanisms and implications - p. page_61 12. Chapter 6: Neurooxidative and neuronitrosative mechanisms in bipolar disorder: Evidence and implications - p. page_71 13. Chapter 7: Mechanisms underpinning neurocognitive dysfunction in bipolar disorder - p. page_85 14. Chapter 8: The biological basis of predominant polarity - p. page_97 15. Chapter 9: The evolution of animal models for bipolar disorder - p. page_109 16. Chapter 10: Alteration in circadian rhythms in bipolar disorder: Mechanisms and implications - p. page_117 17. Chapter 11: Genetic factors in the etiology of bipolar disorder - p. page_129 18. Chapter 12: Pharmacogenomics of bipolar disorder - p. page_135 19. Chapter 13: Blood-brain barrier’s interplay with peripheral and central inflammation as a pathophysiological mechanism of bipolar disorders - p. page_143 20. Chapter 14: Induced pluripotent stem cells as tools to investigate the neurobiology of bipolar disorder and advance novel therapeutic discovery - p. page_155 21. Chapter 15: Bipolar disorder as a gliopathy - p. page_175 22. Chapter 16: Molecular imaging findings in bipolar disorder - p. page_183 23. Chapter 17: Structural neuroimaging findings in bipolar disorders - p. page_197 24. Chapter 18: Epigenetic mechanisms of bipolar disorder - p. page_207 25. Chapter 19: Bipolar disorder and cardiovascular dysfunction: Mechanisms and implications - p. page_223 26. Chapter 20: At-risk mental states for bipolar disorder - p. page_235 27. Chapter 21: Allostatic load: Implications for the pathophysiology, evolution, and treatment of bipolar disorder - p. page_245 28. Chapter 22: Bipolar disorders, obesity, and metabolic disturbances: Mechanisms and implications - p. page_257 29. Chapter 23: The microbiota-gut-brain axis and bipolar disorder - p. page_275 30. Chapter 24: The hypothalamic-pituitary-adrenal axis in bipolar disorder - p. page_285 31. Chapter 25: From intracellular signaling pathways to neural circuit dysfunction in bipolar disorder - p. page_293 32. Chapter 26: The impact of early-life stress in the development and course of bipolar disorder: Mechanisms and implications - p. page_303 33. Chapter 27: Bipolar disorder and accelerated aging: Shared mechanisms and implications - p. page_319 34. Chapter 28: Suicidal behaviors in bipolar disorder - p. page_329 35. Chapter 29: Older-age bipolar disorder - p. page_335 36. Chapter 30: Biomarkers for bipolar disorder - p. page_347 37. Chapter 31: The mechanisms of action of lithium in bipolar disorder - p. page_357 38. Chapter 32: Is there a biosignature for lithium response in bipolar disorder? Evidence and implications - p. page_365 39. Chapter 33: Physical activity and exercise in the pathophysiology and treatment of bipolar disorder - p. page_373 40. Chapter 34: Noninvasive neuromodulatory approaches for bipolar disorder - p. page_383 41. Chapter 35: Novel therapeutic drug targets for bipolar disorder - p. page_393 42. Chapter 36: The treatment of bipolar disorder in the era of precision psychiatry: Challenges and opportunities - p. page_405 43. Chapter 37: Intracortical myelination - p. page_417 44. Chapter 38: The impact of psychotropic drugs on brain functionality and connectivity in bipolar disorder - p. page_427 45. Index - p. page_439
The Neurobiology of Bipolar Disorder: Road to Novel Therapeutics combines the basic neurobiology of bipolar disorder with discussions of the most recent advances in research, including the interacting pathways implicated in the pathophysiology of bipolar disorder, genetic approaches and the pharmacogenomics of bipolar disorder. The basic foundational understanding of the neurobiology underlying the disorder, along with a comprehensive summary of the most recent advances in research combine to aid advanced students and researchers in their understanding of bipolar disorder management using novel and fast-acting pharmaceutical and neuromodulatory approaches.
1. Cover image - p. page_i 2. Title page - p. page_i 3. Table of Contents - p. page_i 4. Copyright - p. page_iv 5. Contributors - p. page_xv 6. Foreword - p. page_xxi 7. Chapter 1: Tackling the heterogeneity of bipolar disorder in the era of the Research Domain Criteria (RDoC) - p. page_1 8. Chapter 2: The neurodevelopmental basis of bipolar disorder: Mechanisms and implications - p. page_11 9. Chapter 3: The neuroprogressive nature of bipolar disorder: Mechanisms and implications - p. page_23 10. Chapter 4: Immune mechanisms in bipolar disorder: Evidence and implications - p. page_37 11. Chapter 5: Mitochondrial pathways in bipolar disorder: Mechanisms and implications - p. page_61 12. Chapter 6: Neurooxidative and neuronitrosative mechanisms in bipolar disorder: Evidence and implications - p. page_71 13. Chapter 7: Mechanisms underpinning neurocognitive dysfunction in bipolar disorder - p. page_85 14. Chapter 8: The biological basis of predominant polarity - p. page_97 15. Chapter 9: The evolution of animal models for bipolar disorder - p. page_109 16. Chapter 10: Alteration in circadian rhythms in bipolar disorder: Mechanisms and implications - p. page_117 17. Chapter 11: Genetic factors in the etiology of bipolar disorder - p. page_129 18. Chapter 12: Pharmacogenomics of bipolar disorder - p. page_135 19. Chapter 13: Blood-brain barrier’s interplay with peripheral and central inflammation as a pathophysiological mechanism of bipolar disorders - p. page_143 20. Chapter 14: Induced pluripotent stem cells as tools to investigate the neurobiology of bipolar disorder and advance novel therapeutic discovery - p. page_155 21. Chapter 15: Bipolar disorder as a gliopathy - p. page_175 22. Chapter 16: Molecular imaging findings in bipolar disorder - p. page_183 23. Chapter 17: Structural neuroimaging findings in bipolar disorders - p. page_197 24. Chapter 18: Epigenetic mechanisms of bipolar disorder - p. page_207 25. Chapter 19: Bipolar disorder and cardiovascular dysfunction: Mechanisms and implications - p. page_223 26. Chapter 20: At-risk mental states for bipolar disorder - p. page_235 27. Chapter 21: Allostatic load: Implications for the pathophysiology, evolution, and treatment of bipolar disorder - p. page_245 28. Chapter 22: Bipolar disorders, obesity, and metabolic disturbances: Mechanisms and implications - p. page_257 29. Chapter 23: The microbiota-gut-brain axis and bipolar disorder - p. page_275 30. Chapter 24: The hypothalamic-pituitary-adrenal axis in bipolar disorder - p. page_285 31. Chapter 25: From intracellular signaling pathways to neural circuit dysfunction in bipolar disorder - p. page_293 32. Chapter 26: The impact of early-life stress in the development and course of bipolar disorder: Mechanisms and implications - p. page_303 33. Chapter 27: Bipolar disorder and accelerated aging: Shared mechanisms and implications - p. page_319 34. Chapter 28: Suicidal behaviors in bipolar disorder - p. page_329 35. Chapter 29: Older-age bipolar disorder - p. page_335 36. Chapter 30: Biomarkers for bipolar disorder - p. page_347 37. Chapter 31: The mechanisms of action of lithium in bipolar disorder - p. page_357 38. Chapter 32: Is there a biosignature for lithium response in bipolar disorder? Evidence and implications - p. page_365 39. Chapter 33: Physical activity and exercise in the pathophysiology and treatment of bipolar disorder - p. page_373 40. Chapter 34: Noninvasive neuromodulatory approaches for bipolar disorder - p. page_383 41. Chapter 35: Novel therapeutic drug targets for bipolar disorder - p. page_393 42. Chapter 36: The treatment of bipolar disorder in the era of precision psychiatry: Challenges and opportunities - p. page_405 43. Chapter 37: Intracortical myelination - p. page_417 44. Chapter 38: The impact of psychotropic drugs on brain functionality and connectivity in bipolar disorder - p. page_427 45. Index - p. page_439
