Neurobiology of Obsessive-Compulsive Disorder provides a comprehensive review of obsessive-compulsive disorder through a neurobiological lens, offering invaluable insights for researchers and clinicians alike. The book begins with a comprehensive introduction to OCD, detailing its definition, historical perspectives, prevalence, and symptomatology, alongside its comorbidities and associated disorders. Delving into the genetic and familial aspects, the book examines genetic predispositions, heritability, and significant genome-wide association studies. In addition, it addresses neuropsychological findings, cognitive dysfunctions, and implications for treatment, alongside neurodevelopmental factors, including early life stress, immune system dysregulation, and environmental risk factors.
Special attention is given to PANDAS/PANS as mechanisms of OCD pathogenesis and the insights gained from animal models. Subsequent chapters cover diagnosis, pharmacological treatments, and a range of psychotherapeutic and behavioral interventions, including CBT, ERP, and ACT, as well as neuromodulation techniques. Finally, the book presents neurobiology-informed treatment approaches, personalized medicine, and integrative strategies, concluding with discussions on current challenges, ethical considerations, and future research directions.
1. Title of Book - p. i 2. Cover image - p. i 3. Title page - p. ii 4. Table of Contents - p. iii 5. Copyright - p. iv 6. Dedication - p. iv 7. List of contributors - p. xiii 8. Conflicts of interest - p. xvii 9. About the editors - p. xix 10. Preface - p. xxi 11. Chapter 1. Understanding obsessive–compulsive disorder - p. 1 12. Chapter 2. Genetics and family studies - p. 25 13. Chapter 3. Neuroanatomy of obsessive compulsive disorder - p. 41 14. Chapter 4. Neurochemistry and neurotransmitters involved in obsessive–compulsive disorder - p. 63 15. Chapter 5. Neuropsychological research in obsessive–compulsive disorder: mechanisms, debates, and ways forward - p. 89 16. Chapter 6. Neurodevelopmental factors in obsessive compulsive disorder - p. 127 17. Chapter 7. Pediatric autoimmune neuropsychiatric disorder associated with streptococcal infections and pediatric acute-onset neuropsychiatric syndrome - p. 175 18. Chapter 8. Animal models of obsessive-compulsive disorder - p. 193 19. Chapter 9. Diagnosing obsessive–compulsive disorder - p. 225 20. Chapter 10. Pharmacological treatments - p. 249 21. Chapter 11. Psychotherapy and behavioral interventions - p. 275 22. Chapter 12. Neurobiology-informed treatment approaches for obsessive–compulsive disorder - p. 309 23. Index - p. 341
Neurobiology of Obsessive-Compulsive Disorder provides a comprehensive review of obsessive-compulsive disorder through a neurobiological lens, offering invaluable insights for researchers and clinicians alike. The book begins with a comprehensive introduction to OCD, detailing its definition, historical perspectives, prevalence, and symptomatology, alongside its comorbidities and associated disorders. Delving into the genetic and familial aspects, the book examines genetic predispositions, heritability, and significant genome-wide association studies. In addition, it addresses neuropsychological findings, cognitive dysfunctions, and implications for treatment, alongside neurodevelopmental factors, including early life stress, immune system dysregulation, and environmental risk factors.
Special attention is given to PANDAS/PANS as mechanisms of OCD pathogenesis and the insights gained from animal models. Subsequent chapters cover diagnosis, pharmacological treatments, and a range of psychotherapeutic and behavioral interventions, including CBT, ERP, and ACT, as well as neuromodulation techniques. Finally, the book presents neurobiology-informed treatment approaches, personalized medicine, and integrative strategies, concluding with discussions on current challenges, ethical considerations, and future research directions.
1. Title of Book - p. i 2. Cover image - p. i 3. Title page - p. ii 4. Table of Contents - p. iii 5. Copyright - p. iv 6. Dedication - p. iv 7. List of contributors - p. xiii 8. Conflicts of interest - p. xvii 9. About the editors - p. xix 10. Preface - p. xxi 11. Chapter 1. Understanding obsessive–compulsive disorder - p. 1 12. Chapter 2. Genetics and family studies - p. 25 13. Chapter 3. Neuroanatomy of obsessive compulsive disorder - p. 41 14. Chapter 4. Neurochemistry and neurotransmitters involved in obsessive–compulsive disorder - p. 63 15. Chapter 5. Neuropsychological research in obsessive–compulsive disorder: mechanisms, debates, and ways forward - p. 89 16. Chapter 6. Neurodevelopmental factors in obsessive compulsive disorder - p. 127 17. Chapter 7. Pediatric autoimmune neuropsychiatric disorder associated with streptococcal infections and pediatric acute-onset neuropsychiatric syndrome - p. 175 18. Chapter 8. Animal models of obsessive-compulsive disorder - p. 193 19. Chapter 9. Diagnosing obsessive–compulsive disorder - p. 225 20. Chapter 10. Pharmacological treatments - p. 249 21. Chapter 11. Psychotherapy and behavioral interventions - p. 275 22. Chapter 12. Neurobiology-informed treatment approaches for obsessive–compulsive disorder - p. 309 23. Index - p. 341
