Neuropsychiatric Disorders and Epigenetics, Second Edition is a comprehensive reference on the epigenetic basis of common neuropsychiatric disorders. The volume is organized into chapters covering individual neuropsychiatric disorders, from addiction to anxiety and autism spectrum disorders, and is contributed by leading experts in their respective fields. The epigenetic aspects of each disorder are discussed, in the context of the full range of associated epigenetic mechanisms, including DNA modification, histone post-translational modification, chromatin organization, and non-coding RNA. A particular emphasis is placed on potential epigenetic interventions, when the effects of environmental stimuli on epigenetic states is particularly relevant to disease.
This new edition has been fully updated to reflect recent research advances enabled by genomic technologies, as well as therapeutic interventions for previously unmanageable disorders. Several new chapters have been added on disorders or approaches not considered in the earlier edition, including epigenetics and anxiety disorders, epigenetics and neuroimaging in neuropsychiatric disorders, genome-wide approaches to epigenetic research, and the epigenetics of spinal muscular atrophy. By helping to define epigenetics as a key player in neuropsychiatric disorders, this volume empowers new research, clinical translation, and pharmacological advances, and highlights promising directions for ongoing investigation.
1. Chapter 1 Introduction to Neuropsychiatric disorders and epigenetics - p. 3 2. Chapter 2 Environmental factors and epigenetics of neuropsychiatric disorders - p. 11 3. Chapter 3 Epigenetic biomarkers in neuropsychiatric disorders - p. 37 4. Chapter 4 Epigenetics and cognitive disorders—translational aspects - p. 53 5. Chapter 5 Epigenetics of autism spectrum disorder - p. 81 6. Chapter 6 Epigenetic causes of intellectual disability—the fragile X syndrome paradigm - p. 103 7. Chapter 7 Epigenetics of attention-deficit hyperactivity disorder - p. 125 8. Chapter 8 Epigenetics and Down syndrome - p. 139 9. Chapter 9 Epigenetics and multiple sclerosis - p. 183 10. Chapter 10 Epigenetics of migraine - p. 225 11. Chapter 11 The role of epigenetics in the pathophysiology of epilepsy - p. 239 12. Chapter 12 Epigenetic dysregulation in brain tumors - p. 269 13. Chapter 13 Epigenetics and cerebrovascular diseases - p. 287 14. Chapter 14 The epigenetics of anxiety - p. 311 15. Chapter 15 Epigenetics and obesity - p. 325 16. Chapter 16 Epigenetics and substance use disorders: translational aspects - p. 353 17. Chapter 17 Neuropsychiatric Disorders and Epigenetics: summary and outlook - p. 381 18. Index - p. 391
Neuropsychiatric Disorders and Epigenetics, Second Edition is a comprehensive reference on the epigenetic basis of common neuropsychiatric disorders. The volume is organized into chapters covering individual neuropsychiatric disorders, from addiction to anxiety and autism spectrum disorders, and is contributed by leading experts in their respective fields. The epigenetic aspects of each disorder are discussed, in the context of the full range of associated epigenetic mechanisms, including DNA modification, histone post-translational modification, chromatin organization, and non-coding RNA. A particular emphasis is placed on potential epigenetic interventions, when the effects of environmental stimuli on epigenetic states is particularly relevant to disease.
This new edition has been fully updated to reflect recent research advances enabled by genomic technologies, as well as therapeutic interventions for previously unmanageable disorders. Several new chapters have been added on disorders or approaches not considered in the earlier edition, including epigenetics and anxiety disorders, epigenetics and neuroimaging in neuropsychiatric disorders, genome-wide approaches to epigenetic research, and the epigenetics of spinal muscular atrophy. By helping to define epigenetics as a key player in neuropsychiatric disorders, this volume empowers new research, clinical translation, and pharmacological advances, and highlights promising directions for ongoing investigation.
1. Chapter 1 Introduction to Neuropsychiatric disorders and epigenetics - p. 3 2. Chapter 2 Environmental factors and epigenetics of neuropsychiatric disorders - p. 11 3. Chapter 3 Epigenetic biomarkers in neuropsychiatric disorders - p. 37 4. Chapter 4 Epigenetics and cognitive disorders—translational aspects - p. 53 5. Chapter 5 Epigenetics of autism spectrum disorder - p. 81 6. Chapter 6 Epigenetic causes of intellectual disability—the fragile X syndrome paradigm - p. 103 7. Chapter 7 Epigenetics of attention-deficit hyperactivity disorder - p. 125 8. Chapter 8 Epigenetics and Down syndrome - p. 139 9. Chapter 9 Epigenetics and multiple sclerosis - p. 183 10. Chapter 10 Epigenetics of migraine - p. 225 11. Chapter 11 The role of epigenetics in the pathophysiology of epilepsy - p. 239 12. Chapter 12 Epigenetic dysregulation in brain tumors - p. 269 13. Chapter 13 Epigenetics and cerebrovascular diseases - p. 287 14. Chapter 14 The epigenetics of anxiety - p. 311 15. Chapter 15 Epigenetics and obesity - p. 325 16. Chapter 16 Epigenetics and substance use disorders: translational aspects - p. 353 17. Chapter 17 Neuropsychiatric Disorders and Epigenetics: summary and outlook - p. 381 18. Index - p. 391
