Neurotoxicity of Nanomaterials and Nanomedicine presents an overview of the exciting research in neurotoxicity and nanomaterials. Nanomaterials have been extensively used in medicine, including diagnosis probes, drug carriers, and embedded materials. While some have been approved for clinical use, most nanomaterials are waiting to be transferred from lab to clinic. However, the toxicity is a main barrier that restricts the translation.
This comprehensive book includes chapters on the most commonly used individual nanoparticles, with information on the applications, neurotoxicity, and related mechanisms of each, providing the most in-depth and current information available. The book examines the pathways that nanomaterials enter into, and eliminate, from the brain, along with the strategies that could reduce the neurotoxicity of nanomaterials.
Providing a background to the subject, detailed information, and ideas for future directions in research, the book is essential for students and researchers in toxicology, and for those in medicine, neurology, pharmacology, pharmaceutical science, and materials science who are researching nanomaterials.
1. Introduction and Overview - p. xix 2. Chapter 1. The Medical Applications of Nanomaterials in the Central Nervous System - p. 1 3. Chapter 2. The Route of Nanomaterials Entering Brain - p. 33 4. Chapter 3. The Distribution and Elimination of Nanomaterials in Brain - p. 59 5. Chapter 4. Current Perspective on Nanomaterial-Induced Adverse Effects: Neurotoxicity as a Case Example - p. 75 6. Chapter 5. Toxicity of Titanium Dioxide Nanoparticles on Brain - p. 99 7. Chapter 6. The Application, Neurotoxicity, and Related Mechanism of Iron Oxide Nanoparticles - p. 127 8. Chapter 7. The Application, Neurotoxicity, and Related Mechanisms of Silver Nanoparticles - p. 151 9. Chapter 8. The Applications, Neurotoxicity, and Related Mechanism of Gold Nanoparticles - p. 179 10. Chapter 9. The Applications, Neurotoxicity, and Related Mechanisms of Manganese-Containing Nanoparticles - p. 205 11. Chapter 10. The Application, Neurotoxicity, and Related Mechanism of Silica Nanoparticles - p. 227 12. Chapter 11. The Synthesis, Application, and Related Neurotoxicity of Carbon Nanotubes - p. 259 13. Chapter 12. The Application, Neurotoxicity, and Related Mechanism of Cationic Polymers - p. 285 14. 1. Classification of Cationic Polymers - p. 287 15. 2. Applications of Cationic Polymers - p. 289 16. 3. Neurotoxicity of Cationic Polymers - p. 303 17. 4. Mechanisms of Cationic Polymers-Induced Neurotoxicity - p. 305 18. 5. Conclusion - p. 317 19. Chapter 13. Perspective on Strategies to Reduce the Neurotoxicity of Nanomaterials and Nanomedicines - p. 331 20. Index - p. 337
Neurotoxicity of Nanomaterials and Nanomedicine presents an overview of the exciting research in neurotoxicity and nanomaterials. Nanomaterials have been extensively used in medicine, including diagnosis probes, drug carriers, and embedded materials. While some have been approved for clinical use, most nanomaterials are waiting to be transferred from lab to clinic. However, the toxicity is a main barrier that restricts the translation.
This comprehensive book includes chapters on the most commonly used individual nanoparticles, with information on the applications, neurotoxicity, and related mechanisms of each, providing the most in-depth and current information available. The book examines the pathways that nanomaterials enter into, and eliminate, from the brain, along with the strategies that could reduce the neurotoxicity of nanomaterials.
Providing a background to the subject, detailed information, and ideas for future directions in research, the book is essential for students and researchers in toxicology, and for those in medicine, neurology, pharmacology, pharmaceutical science, and materials science who are researching nanomaterials.
1. Introduction and Overview - p. xix 2. Chapter 1. The Medical Applications of Nanomaterials in the Central Nervous System - p. 1 3. Chapter 2. The Route of Nanomaterials Entering Brain - p. 33 4. Chapter 3. The Distribution and Elimination of Nanomaterials in Brain - p. 59 5. Chapter 4. Current Perspective on Nanomaterial-Induced Adverse Effects: Neurotoxicity as a Case Example - p. 75 6. Chapter 5. Toxicity of Titanium Dioxide Nanoparticles on Brain - p. 99 7. Chapter 6. The Application, Neurotoxicity, and Related Mechanism of Iron Oxide Nanoparticles - p. 127 8. Chapter 7. The Application, Neurotoxicity, and Related Mechanisms of Silver Nanoparticles - p. 151 9. Chapter 8. The Applications, Neurotoxicity, and Related Mechanism of Gold Nanoparticles - p. 179 10. Chapter 9. The Applications, Neurotoxicity, and Related Mechanisms of Manganese-Containing Nanoparticles - p. 205 11. Chapter 10. The Application, Neurotoxicity, and Related Mechanism of Silica Nanoparticles - p. 227 12. Chapter 11. The Synthesis, Application, and Related Neurotoxicity of Carbon Nanotubes - p. 259 13. Chapter 12. The Application, Neurotoxicity, and Related Mechanism of Cationic Polymers - p. 285 14. 1. Classification of Cationic Polymers - p. 287 15. 2. Applications of Cationic Polymers - p. 289 16. 3. Neurotoxicity of Cationic Polymers - p. 303 17. 4. Mechanisms of Cationic Polymers-Induced Neurotoxicity - p. 305 18. 5. Conclusion - p. 317 19. Chapter 13. Perspective on Strategies to Reduce the Neurotoxicity of Nanomaterials and Nanomedicines - p. 331 20. Index - p. 337
