There are numerous monographs devoted to rheumatoid arthritis. What sets this issue apart is that it keeps an eye to the future. Topics explored include measurement of RA disease activity today and in the future; epidemiology of RA – implications for prevention and risk assessment; genes that predispose to RA – relevance to current and future therapeutic strategies; multiple kinases – assessment of the best targets in treating RA; assessment, prevention and treatment of cardiovascular morbidity in RA; mechanistic insights and approaches to prevention of bone damage in RA; cell-cell interactions in RA synovium as potential new targets for treatment; alternative strategies for modulating the function of B lymphocytes in RA; innate immunity in RA; ascertainment and management of preclinical RA.
1. Cover - p. 1 2. Contributors - p. 2 3. Contents - p. 3 4. Forthcoming Issues - p. 4 5. Preface - p. 5 6. Preclinical Rheumatoid Arthritis: Identification, Evaluation, and Future Directions for Investigation - p. 6 7. How Should Rheumatoid Arthritis Disease Activity Be Measured Today and in the Future in Clinical Care? - p. 21 8. Leveraging Human Genetics to Develop Future Therapeutic Strategies in Rheumatoid Arthritis - p. 30 9. Innate Immunity and Rheumatoid Arthritis - p. 36 10. Immune Aging and Rheumatoid Arthritis - p. 52 11. Cell-cell Interactions in Rheumatoid Arthritis Synovium - p. 61 12. B Cell Therapies for Rheumatoid Arthritis: Beyond B cell Depletion - p. 69 13. Targeting IL-17 and Th17 Cells in Rheumatoid Arthritis - p. 79 14. A Multitude of Kinases—Which are the Best Targets in Treating Rheumatoid Arthritis? - p. 93 15. Bone Damage in Rheumatoid Arthritis: Mechanistic Insights and Approaches to Prevention - p. 104 16. Cardiovascular Complications of Rheumatoid Arthritis: Assessment, Prevention, and Treatment - p. 117 17. Index - p. 130
There are numerous monographs devoted to rheumatoid arthritis. What sets this issue apart is that it keeps an eye to the future. Topics explored include measurement of RA disease activity today and in the future; epidemiology of RA – implications for prevention and risk assessment; genes that predispose to RA – relevance to current and future therapeutic strategies; multiple kinases – assessment of the best targets in treating RA; assessment, prevention and treatment of cardiovascular morbidity in RA; mechanistic insights and approaches to prevention of bone damage in RA; cell-cell interactions in RA synovium as potential new targets for treatment; alternative strategies for modulating the function of B lymphocytes in RA; innate immunity in RA; ascertainment and management of preclinical RA.
1. Cover - p. 1 2. Contributors - p. 2 3. Contents - p. 3 4. Forthcoming Issues - p. 4 5. Preface - p. 5 6. Preclinical Rheumatoid Arthritis: Identification, Evaluation, and Future Directions for Investigation - p. 6 7. How Should Rheumatoid Arthritis Disease Activity Be Measured Today and in the Future in Clinical Care? - p. 21 8. Leveraging Human Genetics to Develop Future Therapeutic Strategies in Rheumatoid Arthritis - p. 30 9. Innate Immunity and Rheumatoid Arthritis - p. 36 10. Immune Aging and Rheumatoid Arthritis - p. 52 11. Cell-cell Interactions in Rheumatoid Arthritis Synovium - p. 61 12. B Cell Therapies for Rheumatoid Arthritis: Beyond B cell Depletion - p. 69 13. Targeting IL-17 and Th17 Cells in Rheumatoid Arthritis - p. 79 14. A Multitude of Kinases—Which are the Best Targets in Treating Rheumatoid Arthritis? - p. 93 15. Bone Damage in Rheumatoid Arthritis: Mechanistic Insights and Approaches to Prevention - p. 104 16. Cardiovascular Complications of Rheumatoid Arthritis: Assessment, Prevention, and Treatment - p. 117 17. Index - p. 130
