New Insights on the Development of the Vascular System examines the most recent literature and data on the development of the vascular system, along with advice on new laboratory techniques and approaches to data analysis. This volume is a comprehensive handbook to the state-of-the-art in vascular system development. Several genetic and epigenetic mechanisms are involved in the early development of the vascular system, and there is extensive literature on the genetic background and molecular mechanisms responsible for blood vessel formation. Yet new data and techniques have been developed in recent years.
Although scientific literature covers the descriptive aspects of embryonic vascular system development, modern techniques such as the technology of cell fusion, cell sorting and image analysis give new insight into the mechanisms by which vessels form and regress and how blood flow changes directions in the same vessels.
1. Chapter 1. Introduction - p. 1 2. Chapter 2. Vasculogenesis - p. 9 3. Chapter 3. Angiogenesis - p. 19 4. Chapter 4. Nonsprouting angiogenesis: Intussusceptive microvascular growth - p. 27 5. Chapter 5. Endothelial tip, stalk, and phalanx cells - p. 33 6. Chapter 6. Role of neuropilins - p. 39 7. Chapter 7. Role of notch and notch ligands - p. 41 8. Chapter 8. Semaphorins and netrin-UNC5B signaling - p. 45 9. Chapter 9. Lumen formation and perfusion - p. 49 10. Chapter 10. Network formation - p. 53 11. Chapter 11. Remodeling - p. 57 12. Chapter 12. Pruning - p. 62 13. Chapter 13. Maturation and stabilization and pericyte recruitment - p. 65 14. Chapter 14. Arteriogenesis - p. 75 15. Chapter 15. Arterial and venous specification - p. 81 16. Chapter 16. Role of oxygen - p. 87 17. Chapter 17. Epigenetic regulation of vascular development (microRNAs) - p. 89 18. Chapter 18. Angiogenesis and organogenesis - p. 93 19. Chapter 19. Concluding remarks - p. 107 20. Index - p. 111
New Insights on the Development of the Vascular System examines the most recent literature and data on the development of the vascular system, along with advice on new laboratory techniques and approaches to data analysis. This volume is a comprehensive handbook to the state-of-the-art in vascular system development. Several genetic and epigenetic mechanisms are involved in the early development of the vascular system, and there is extensive literature on the genetic background and molecular mechanisms responsible for blood vessel formation. Yet new data and techniques have been developed in recent years.
Although scientific literature covers the descriptive aspects of embryonic vascular system development, modern techniques such as the technology of cell fusion, cell sorting and image analysis give new insight into the mechanisms by which vessels form and regress and how blood flow changes directions in the same vessels.
1. Chapter 1. Introduction - p. 1 2. Chapter 2. Vasculogenesis - p. 9 3. Chapter 3. Angiogenesis - p. 19 4. Chapter 4. Nonsprouting angiogenesis: Intussusceptive microvascular growth - p. 27 5. Chapter 5. Endothelial tip, stalk, and phalanx cells - p. 33 6. Chapter 6. Role of neuropilins - p. 39 7. Chapter 7. Role of notch and notch ligands - p. 41 8. Chapter 8. Semaphorins and netrin-UNC5B signaling - p. 45 9. Chapter 9. Lumen formation and perfusion - p. 49 10. Chapter 10. Network formation - p. 53 11. Chapter 11. Remodeling - p. 57 12. Chapter 12. Pruning - p. 62 13. Chapter 13. Maturation and stabilization and pericyte recruitment - p. 65 14. Chapter 14. Arteriogenesis - p. 75 15. Chapter 15. Arterial and venous specification - p. 81 16. Chapter 16. Role of oxygen - p. 87 17. Chapter 17. Epigenetic regulation of vascular development (microRNAs) - p. 89 18. Chapter 18. Angiogenesis and organogenesis - p. 93 19. Chapter 19. Concluding remarks - p. 107 20. Index - p. 111
