In this thematic volume of Progress in Molecular Biology and Translational Science, researchers reflect on recent developments and research surrounding G protein-coupled receptors. The chapters cover a large breadth of research, including GPCR role in stem cell function and pharmacology. Authors explore in-depth research techniques and applications of GPCR usage, covering theory, laboratory approaches, and unique qualities that make GPCRs a crucial tool in microbiological and cancer research.
Key features:
* Contributions from leading authorities * Informs and updates on all the latest developments in the field
1. Cover image 2. Title page 3. Table of Contents 4. Copyright 5. Contributors 6. Preface 7. Chapter One. Approaches for Probing Allosteric Interactions at 7 Transmembrane Spanning Receptors 8. Chapter Two. Pharmacology of Metabotropic Glutamate Receptor Allosteric Modulators 9. Chapter Three. Mining the Potential of Label-Free Biosensors for Seven-Transmembrane Receptor Drug Discovery 10. Chapter Four. G Protein-Coupled Receptors in Cancer 11. Chapter Five. GPCRs in Stem Cell Function 12. Chapter Six. Application of Receptor Theory to Allosteric Modulation of Receptors 13. Chapter Seven. What Ligand-Gated Ion Channels Can Tell Us About the Allosteric Regulation of G Protein-Coupled Receptors 14. Chapter Eight. Modeling Cooperativity Effects in Dimeric G Protein-Coupled Receptors 15. Chapter Nine. Chemokine Receptor Oligomerization and Allostery 16. Chapter Ten. Fine-Tuning of GPCR Signals by Intracellular G Protein Modulators 17. Index
In this thematic volume of Progress in Molecular Biology and Translational Science, researchers reflect on recent developments and research surrounding G protein-coupled receptors. The chapters cover a large breadth of research, including GPCR role in stem cell function and pharmacology. Authors explore in-depth research techniques and applications of GPCR usage, covering theory, laboratory approaches, and unique qualities that make GPCRs a crucial tool in microbiological and cancer research.
Key features:
* Contributions from leading authorities * Informs and updates on all the latest developments in the field
1. Cover image 2. Title page 3. Table of Contents 4. Copyright 5. Contributors 6. Preface 7. Chapter One. Approaches for Probing Allosteric Interactions at 7 Transmembrane Spanning Receptors 8. Chapter Two. Pharmacology of Metabotropic Glutamate Receptor Allosteric Modulators 9. Chapter Three. Mining the Potential of Label-Free Biosensors for Seven-Transmembrane Receptor Drug Discovery 10. Chapter Four. G Protein-Coupled Receptors in Cancer 11. Chapter Five. GPCRs in Stem Cell Function 12. Chapter Six. Application of Receptor Theory to Allosteric Modulation of Receptors 13. Chapter Seven. What Ligand-Gated Ion Channels Can Tell Us About the Allosteric Regulation of G Protein-Coupled Receptors 14. Chapter Eight. Modeling Cooperativity Effects in Dimeric G Protein-Coupled Receptors 15. Chapter Nine. Chemokine Receptor Oligomerization and Allostery 16. Chapter Ten. Fine-Tuning of GPCR Signals by Intracellular G Protein Modulators 17. Index
