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Kidney disease and cancer are frequent comorbidities that require specialized knowledge and expertise from both the nephrologist and the oncologist. Written by three pioneers in this growing subspecialty, Onco-Nephrology provides authoritative, definitive coverage of the mechanism and management of these two life-threatening diseases. This unique, single-volume resource covers current protocols and recommends management therapies to arrest kidney failure and allow oncologic treatments to continue and succeed.

  • Addresses acute and chronic kidney diseases that develop from a variety of cancers. This includes direct kidney injury from the malignancy, paraneoplastic effects of the cancer, and various cancer agents used to treat the malignancy.
  • Discusses key issues regarding kidney disease in patients with cancer, including conventional chemotherapeutic regimens and new novel therapies (targeted agents and immunotherapies) or the malignancies themselves that may promote kidney injury; patients with chronic kidney disease who acquire cancer unrelated to renal failure; and kidney transplantation, which has been shown to carry an increased risk of cancer.
  • Contains dedicated chapters for each class of the conventional chemotherapeutic agents, targeted cancer agents, and cancer immunotherapies including the basic science, pathogenic mechanisms of injury, clinical manifestations, and treatment.
  • Includes special chapters devoted to the individual classes of chemotherapies that relate to kidney disease for quick reference. Discusses increasingly complex problems due to more numerous and specialized anti-cancer drugs, as well as increased survival rates for both cancer and renal failure requiring long-term patient care.
  • Covers anti-VEGF (antivascular endothelial growth factor) agents and cancer immunotherapies – treatments that are being recognized for adverse kidney effects.
  • Utilizes a clear, logical format based on the ASN Core Curriculum for Onco-Nephrology, making this reference an excellent tool for board review, as well as a practical resource in daily practice.
  • Enhanced eBook version included with purchase. Your enhanced eBook allows you to access all of the text, figures, and references from the book on a variety of devices.

1. Cover image - p. i 2. Title page - p. ii 3. Table of Contents - p. iii 4. Inside front cover - p. iii 5. Copyright - p. iii 6. Dedication - p. iii 7. Contributors - p. iii 8. Preface - p. iii 9. SECTION 1: Fluid and Electrolyte Disorders in Cancer Patients - p. iii 10. List of Illustrations - p. iii 11. List of Tables - p. iii 12. Chapter 1: Kidney function - p. iii 13. Chapter 2: Dysnatremias in cancer - p. 8 14. Chapter 3: Potassium disorders - p. 18 15. Chapter 4: Calcium and phosphorus disorders - p. 28 16. Chapter 5: Volume disorders and fluid resuscitation - p. 44 17. SECTION 2: Paraprotein-Related Kidney Diseases - p. 52 18. Chapter 6: Paraproteins - p. 52 19. Chapter 7: Cast nephropathy - p. 58 20. Chapter 8: Systemic light chain amyloidosis - p. 66 21. Chapter 9: Monoclonal immunoglobulin deposition disease - p. 75 22. Chapter 10: Fibrillary and immunotactoid glomerulonephritis - p. 84 23. SECTION 3: Hematopoietic Stem Cell Associated Kidney Disease - p. 87 24. Chapter 11: Hematopoietic cell transplant associated kidney injury - p. 87 25. Chapter 12: Sinusoidal obstruction syndrome - p. 98 26. Chapter 13: Thrombotic microangiopathy - p. 106 27. Chapter 14: Graft-versus-host disease - p. 113 28. Chapter 15: Chronic kidney disease, end-stage renal disease, and bone marrow transplant - p. 117 29. SECTION 4: Chemotherapy and Radiation Related Kidney Diseases - p. 125 30. Chapter 16: Conventional chemotherapy - p. 125 31. Chapter 17: Targeted cancer therapies (biologics) - p. 153 32. Chapter 18: Adverse kidney effects of immunotherapies - p. 165 33. Chapter 19: Chemotherapy in chronic kidney disease and dialysis - p. 182 34. Chapter 20: Radiation nephropathy - p. 196 35. SECTION 5: Paraneoplastic Glomerulopathies - p. 203 36. Chapter 21: Paraneoplastic glomerular diseases - p. 203 37. Chapter 22: Paraneoplastic glomerulonephritis - p. 212 38. Chapter 23: Hematologic malignancies - p. 218 39. Chapter 24: Cancer screening recommendations - p. 224 40. SECTION 6: Renal Tumors - p. 228 41. Chapter 25: Renal cell cancer - p. 228 42. Chapter 26: Wilms tumor and von hippel lindau disease - p. 243 43. Chapter 27: Tuberous sclerosis complex and the kidney - p. 250 44. Chapter 28: Evaluation of a renal cyst/mass - p. 258 45. SECTION 7: Acute Kidney Injury - p. 267 46. Chapter 29: Acute kidney injury incidence, pathogenesis, and outcomes - p. 267 47. Chapter 30: Tumor lysis syndrome - p. 274 48. Chapter 31: Obstructive nephropathy in cancer - p. 280 49. Chapter 32: Renal replacement therapies - p. 289 50. SECTION 8: Chronic Kidney Disease and Cancer - p. 298 51. Chapter 33: Chronic kidney disease as a complication of cancer, with special focus on kidney and urothelial tumors - p. 298 52. Chapter 34: Incidence of cancer and screening recommendations - p. 306 53. Chapter 35: Cancer in renal transplant patients - p. 313 54. SECTION 9: Kidney Infections - p. 321 55. Chapter 36: Renal infections in cancer patients - p. 321 56. SECTION 10: Infiltrative Diseases - p. 335 57. Chapter 37: Kidney disease in leukemia - p. 335 58. Chapter 38: Kidney disease in lymphoma - p. 346 59. Index - p. 354

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Descripcion
Descripción

Kidney disease and cancer are frequent comorbidities that require specialized knowledge and expertise from both the nephrologist and the oncologist. Written by three pioneers in this growing subspecialty, Onco-Nephrology provides authoritative, definitive coverage of the mechanism and management of these two life-threatening diseases. This unique, single-volume resource covers current protocols and recommends management therapies to arrest kidney failure and allow oncologic treatments to continue and succeed.

  • Addresses acute and chronic kidney diseases that develop from a variety of cancers. This includes direct kidney injury from the malignancy, paraneoplastic effects of the cancer, and various cancer agents used to treat the malignancy.
  • Discusses key issues regarding kidney disease in patients with cancer, including conventional chemotherapeutic regimens and new novel therapies (targeted agents and immunotherapies) or the malignancies themselves that may promote kidney injury; patients with chronic kidney disease who acquire cancer unrelated to renal failure; and kidney transplantation, which has been shown to carry an increased risk of cancer.
  • Contains dedicated chapters for each class of the conventional chemotherapeutic agents, targeted cancer agents, and cancer immunotherapies including the basic science, pathogenic mechanisms of injury, clinical manifestations, and treatment.
  • Includes special chapters devoted to the individual classes of chemotherapies that relate to kidney disease for quick reference. Discusses increasingly complex problems due to more numerous and specialized anti-cancer drugs, as well as increased survival rates for both cancer and renal failure requiring long-term patient care.
  • Covers anti-VEGF (antivascular endothelial growth factor) agents and cancer immunotherapies – treatments that are being recognized for adverse kidney effects.
  • Utilizes a clear, logical format based on the ASN Core Curriculum for Onco-Nephrology, making this reference an excellent tool for board review, as well as a practical resource in daily practice.
  • Enhanced eBook version included with purchase. Your enhanced eBook allows you to access all of the text, figures, and references from the book on a variety of devices.

1. Cover image - p. i 2. Title page - p. ii 3. Table of Contents - p. iii 4. Inside front cover - p. iii 5. Copyright - p. iii 6. Dedication - p. iii 7. Contributors - p. iii 8. Preface - p. iii 9. SECTION 1: Fluid and Electrolyte Disorders in Cancer Patients - p. iii 10. List of Illustrations - p. iii 11. List of Tables - p. iii 12. Chapter 1: Kidney function - p. iii 13. Chapter 2: Dysnatremias in cancer - p. 8 14. Chapter 3: Potassium disorders - p. 18 15. Chapter 4: Calcium and phosphorus disorders - p. 28 16. Chapter 5: Volume disorders and fluid resuscitation - p. 44 17. SECTION 2: Paraprotein-Related Kidney Diseases - p. 52 18. Chapter 6: Paraproteins - p. 52 19. Chapter 7: Cast nephropathy - p. 58 20. Chapter 8: Systemic light chain amyloidosis - p. 66 21. Chapter 9: Monoclonal immunoglobulin deposition disease - p. 75 22. Chapter 10: Fibrillary and immunotactoid glomerulonephritis - p. 84 23. SECTION 3: Hematopoietic Stem Cell Associated Kidney Disease - p. 87 24. Chapter 11: Hematopoietic cell transplant associated kidney injury - p. 87 25. Chapter 12: Sinusoidal obstruction syndrome - p. 98 26. Chapter 13: Thrombotic microangiopathy - p. 106 27. Chapter 14: Graft-versus-host disease - p. 113 28. Chapter 15: Chronic kidney disease, end-stage renal disease, and bone marrow transplant - p. 117 29. SECTION 4: Chemotherapy and Radiation Related Kidney Diseases - p. 125 30. Chapter 16: Conventional chemotherapy - p. 125 31. Chapter 17: Targeted cancer therapies (biologics) - p. 153 32. Chapter 18: Adverse kidney effects of immunotherapies - p. 165 33. Chapter 19: Chemotherapy in chronic kidney disease and dialysis - p. 182 34. Chapter 20: Radiation nephropathy - p. 196 35. SECTION 5: Paraneoplastic Glomerulopathies - p. 203 36. Chapter 21: Paraneoplastic glomerular diseases - p. 203 37. Chapter 22: Paraneoplastic glomerulonephritis - p. 212 38. Chapter 23: Hematologic malignancies - p. 218 39. Chapter 24: Cancer screening recommendations - p. 224 40. SECTION 6: Renal Tumors - p. 228 41. Chapter 25: Renal cell cancer - p. 228 42. Chapter 26: Wilms tumor and von hippel lindau disease - p. 243 43. Chapter 27: Tuberous sclerosis complex and the kidney - p. 250 44. Chapter 28: Evaluation of a renal cyst/mass - p. 258 45. SECTION 7: Acute Kidney Injury - p. 267 46. Chapter 29: Acute kidney injury incidence, pathogenesis, and outcomes - p. 267 47. Chapter 30: Tumor lysis syndrome - p. 274 48. Chapter 31: Obstructive nephropathy in cancer - p. 280 49. Chapter 32: Renal replacement therapies - p. 289 50. SECTION 8: Chronic Kidney Disease and Cancer - p. 298 51. Chapter 33: Chronic kidney disease as a complication of cancer, with special focus on kidney and urothelial tumors - p. 298 52. Chapter 34: Incidence of cancer and screening recommendations - p. 306 53. Chapter 35: Cancer in renal transplant patients - p. 313 54. SECTION 9: Kidney Infections - p. 321 55. Chapter 36: Renal infections in cancer patients - p. 321 56. SECTION 10: Infiltrative Diseases - p. 335 57. Chapter 37: Kidney disease in leukemia - p. 335 58. Chapter 38: Kidney disease in lymphoma - p. 346 59. Index - p. 354

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